Our profile

  "Physiology" we define by a central question: "How does it work?"

  For answering this question we apply several methods including molecular biology, electrophysiology, microbiology, biophysics, laser-scanning microscopy, and freeze-fracture electron microscopy

  We investigate all levels of the organism: molecules, cells, tissues, organs, and the whole body

  Our approach is translational as it combines basic research with topics related to diseases of the intestines, kidneys, nerves, and skin

  Main research topics are the tight junction and membrane channel molecules of the "intelligent borders of the body", the epithelia

  We perform numerous collaborative projects with colleagues from clinical departments

  Clinical Physiology / Nutritional Medicine is a unit within the Dept. of Gastroenterology, Rheumatology, and Infectious Diseases, located on the Campus Benjamin Franklin

• Citi S, Fromm M, Furuse M, Gonzalez-Marical L, Nusrat A, Tsukita S, Turner JR (2024) A short guide to the tight junction. J. Cell Sci. 137: jcs261776 (10 pages), doi: 10.1242/jcs.261776 (°IF 4.0) (in press)

• Nagarajan SK, Piontek J (2024) Molecular dynamics simulations of claudin-10a and -10b ion channels: With similar architecture, different pore linings determine the opposite charge selectivity. Int. J. Mol. Sci. 25(6): 3161 (23 pages), doi: 10.3390/ijms25063161 (°IF 5.6) 

• Pfeffer T*, Krug SM* (*shared first authorship), ... ... ... Schmitt CP°, Peters V° (°shared last authorship) (2024) Knock-out of dipeptidase CN2 in human proximal tubular cells disrupts dipeptide and amino acid homeostasis and para- and transcellular solute transport. Acta Physiol.240(#): e14126 (20 pages), doi: 10.1111/apha.14126 (°IF 6.4)