Institut für Klinische Physiologie

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Seminar Pathophysiologie: Untersuchungsmethoden und Erkenntnisse

(Forschungsmodul A or B) 

WiSe 2020/21
 für Bioinformatiker

Termin / dates: do be determined
Ort / location: 
CBF Haupthaus (Hindenburgdamm 30), room: 5573 (fifth floor)
Anmeldung Dorothee Günzel


Jede/r Teilnehmer/in hält ein 35-min-Referat über ein von den Dozenten angebotenes aktuelles Thema der Pathophysiologie 






Anforderungen: maximal ein Fehltermin.
Fahrverbindung:  U- oder S-Bahnhof "Rathaus Steglitz", dann Bus M85 oder 285 bis "Universitätsklinikum Benjamin Franklin" (Eingang Hindenburdamm) Stadtplan


Datum Referent/in Themen Moderator/in  
    Selection of topics:    
    New (continually updated):    
    Native South Americans reached Polynesia early    
    Arctic-adapted dogs emerged at the Pleistocene–Holocene transition    
    Does being multi-headed make you better at solving problems? A survey of Physarum-based models and computations    
    Ancient pigs reveal a near-complete genomic turnover
following their introduction to Europe
    Out of Southern East Asia of the Brown Rat Revealed by Large-Scale Genome Sequencing    
    Bacterial and viral evolution:    
    Computational Prediction of Usutu Virus E Protein B
Cell and T Cell Epitopes for Potential Vaccine
    Chromulinavorax destructans, a pathogenic TM6 bacterium with an unusual replication strategy targeting protist mitochondrion    
    Molecular evolution of Zika virus as it crossed the Pacific to the Americas    
    Antisense inhibition of selenoprotein synthesis by Zika virus may contribute to neurological disorders and microcephaly by mimicking SePP1 knockout and the genetic disease progressive cerebello-cerebral atrophy (    
    Molecular Evolution of Zika Virus during Its Emergence in the 20 th Century

additional information in:

Anticipating the international spread of Zika virus from Brazil

Zika virus genome from the Americas

Computational prediction and analysis of potential antigenic CTL epitopes in Zika virus: A first step towards vaccine development

    Evolution of extensively drug-resistant tuberculosis over four decades: whole genome sequencing and dating analysis of Mycobacterium tuberculosis isolates from KwaZulu-Natal    
    Early Divergent Strains of Yersinia pestis in Eurasia
5,000 Years Ago
    A draft genome of Yersinia pestis from victims of the Black Death    
    Yersinia pestis genome sequencing identifies patterns of global phylogenetic diversity


Historical variations in mutation rate in an epidemic pathogen, Yersinia pestis
    17th Century Variola Virus Reveals the Recent History of Smallpox    
    The early spread and epidemic ignition of HIV-1 in human populations    
    1970s and ‘Patient 0’ HIV-1 genomes illuminate early HIV/AIDS history in North America    
    Sequencing prehistoric DNA/human evolution:    
    Kinship-based social inequality in Bronze Age Europe    
    The genome of the offspring of a Neanderthal mother and a Denisovan father    
    An early modern human from Romania with a recent Neanderthal ancestor    
    Neanderthal behaviour, diet, and disease inferred
from ancient DNA in dental calculus
    Reconstructing the DNA Methylation Maps of the Neandertal and the Denisovan    
    Population genomic analysis of elongated skulls reveals extensive female-biased immigration in Early Medieval Bavaria    
    Neandertal and Denisovan DNA from Pleistocene sediments    
    The 5300-year-old Helicobacter pylori genome of the Iceman    

Genomic and archaeological evidence
suggests a dual origin of domestic dogs

    Complete Mitochondrial Genomes of Ancient Canids Suggest a European Origin of Domestic Dogs   +   Ancient DNA Analysis Affirms the Canid from Altai as a Primitive Dog    
    Ancient human genomes suggest three ancestral populations for present-day Europeans    

Ancient gene flow from early modern humans into Eastern Neanderthals


Excavating Neandertal and Denisovan DNA from the genomes of Melanesian individuals

    Population genomics of Bronze Age Eurasia    
    Massive migration from the steppe was a source for Indo-European languages in Europe    
    The genetic history of Ice Age Europe    
    Y Chromosomes of 40% Chinese Descend from Three Neolithic Super-Grandfathers    
    Mikrobiome analysis:    
    The chemical interactome space between the human host and the genetically defined gut metabotypes    
    Metagenomic systems biology of the human gut microbiome reveals topological shifts associated with obesity and inflammatory bowel disease    
    The microbiome of uncontacted Amerindians    
    Bacterial phylogeny structures soil resistomes across habitats.    
    Empirical genome evolution models root the tree of life    
    Akaryotes and Eukaryotes are independent descendants of a universal common ancestor    
    Asgard archaea illuminate the origin of eukaryotic cellular complexity    
    The physiology and habitat of the last universal common ancestor (additional information in: Physiology, phylogeny, and LUCA)    

Global population divergence and admixture of the brown rat (Rattus norvegicus)


Progressive Loss of Function in a Limb Enhancer during Snake Evolution

    Loss and Re-emergence of Legs in Snakes by Modular Evolution of Sonic hedgehog and HOXD Enhancers.    
    The herring gull complex is not a ring species    
    Ring distributions leading to species formation: a global topographic analysis of geographic barriers associated with ring species    
    Evolution and stability of ring species    

Evolution of the vertebrate claudin gene family:
insights from a basal vertebrate, the sea lamprey

    Machine learning for integrating data in biology and medicine: Principles, practice, and opportunities    
    Lipidome determinants of maximal lifespan in mammals    

A bacterium that degrades and
assimilates poly(ethylene terephthalate)

    Eigene Vorschläge / own suggetions    


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