Institut für Klinische Physiologie

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Seminar Pathophysiologie: Untersuchungsmethoden und Erkenntnisse

(Neue Studienordnung: Forschungsmodul B; alte Studienordnung: Modul B) 

WiSe 2016/17
 für Bioinformatiker

Termin / dates: planned for 20th - 24th of February 2017, 9 - 13
Ort / location: 
CBF Haupthaus (Hindenburgdamm 30), room: to be announced
Anmeldung Dorothee Günzel


Jede/r Teilnehmer/in hält ein 35-min-Referat über ein von den Dozenten angebotenes aktuelles Thema der Pathophysiologie 


Für Studierende nach der neuen Studienordnung: ohne Benotung, keine Webskripte erforderlich



Für Studierende nach der alten Studienordnung: 

Teilnehmer erstellen eine inhaltlich gute Web-Skripte Text & Abbildungen; Gewichtung 60% Referat, 40% Webskripte; 4 Credits



Anforderungen: maximal ein Fehltermin.
Fahrverbindung:  U- oder S-Bahnhof "Rathaus Steglitz", dann Bus M85 oder 285 bis "Universitätsklinikum Benjamin Franklin" (Eingang Hindenburdamm) Stadtplan


Datum Referent/in Themen Moderator/in  
20.10.2016 4 pm Dorothee Günzel Introduction, topic assignment, fixing date etc. 
20.2.2017 Dorothee Günzel Bringing together bioinformatics, pathophysiology, history, evolution and a pinch of intelligent design    
20.2.2017 Daniel Whitfield The herring gull complex is not a ring species Christian Knauth  
22.2.2017 Max Driller The genetic history of Ice Age Europe Jessica Walde  
22.2.2017 Xuesong Wang Y Chromosomes of 40% Chinese Descend from Three Neolithic Super-Grandfathers Jonathan Baumann  
22.2.2017 Viktor Dinkel A practical, inexpensive screening test that could detect and monitor early Alzheimer’s disease (AD) pathology, before irreversible brain atrophy occurs Pratik Dhakal  
22.2.2017 Jens Hagemeister Potential Mechanisms for Cancer Resistance in Elephants and Comparative Cellular Response to DNA Damage in Humans Boran Adas  
23.2.2017 Enrico Seiler The human microbiome: A hot spot of microbial horizontal gene transfer Svetlana Leng  
23.2.2017 Christian Knauth The microbiome of uncontacted Amerindians Daniel Whitfield  
23.2.2017 Jonathan Baumann A draft genome of Yersinia pestis form victims of the Black Death Max Driller  
23.2.2017 Jessica Walde 17th Century Variola Virus Reveals the Recent History of Smallpox Xuesong Wang  
24.2.2017 Pratik Dhakal The early spread and epidemic ignition of HIV-1 in human populations Viktor Dinkel  
24.2.2017 Boran Adas 1970s and ‘Patient 0’ HIV-1 genomes illuminate early HIV/AIDS history in North America Jens Hagemeister  
24.2.2017 Svetlana Leng Molecular Evolution of Zika Virus during Its Emergence in the 20th Century
additional information:
Anticipating the international spread of Zika virus from Brazil
Zika virus genome from the Americas
Enrico Seiler  
    Selection of topics:    

Progressive Loss of Function in a Limb Enhancer during Snake Evolution

    17th Century Variola Virus Reveals the Recent History of Smallpox    
    Population analysis:    
    Molecular Evolution of Zika Virus during Its Emergence in the 20 th Century

additional information:

Anticipating the international spread of Zika virus from Brazil

Zika virus genome from the Americas

Computational prediction and analysis of potential antigenic CTL epitopes in Zika virus: A first step towards vaccine development

    A draft genome of Yersinia pestis from victims of the Black Death    
    Yersinia pestis genome sequencing identifies patterns of global phylogenetic diversity


Historical variations in mutation rate in an epidemic pathogen, Yersinia pestis
    Early Divergent Strains of Yersinia pestis in Eurasia
5,000 Years Ago
    Evolution of extensively drug-resistant tuberculosis over four decades: whole genome sequencing and dating analysis of Mycobacterium tuberculosis isolates from KwaZulu-Natal    

Global population divergence and admixture of the brown rat (Rattus norvegicus)

    Population genomics of Bronze Age Eurasia    
    Massive migration from the steppe was a source for Indo-European languages in Europe    
    Mikrobiome analysis:    
    The chemical interactome space between the human host and the genetically defined gut metabotypes    
    Metagenomic systems biology of the human gut microbiome reveals topological shifts associated with obesity and inflammatory bowel disease    
    16S rRNA gene pyrosequencing of reference and clinical samples and investigation of the temperature stability of microbiome profiles      
    Ring distributions leading to species formation: a global topographic analysis of geographic barriers associated with ring species    
    Evolution and stability of ring species    

Evolution of the vertebrate claudin gene family:
insights from a basal vertebrate, the sea lamprey


The physiology and habitat of the last universal
common ancestor

    Sequencing prehistoric DNA:    
    The 5300-year-old Helicobacter pylori genome of the Iceman    

Genomic and archaeological evidence
suggests a dual origin of domestic dogs

    Complete Mitochondrial Genomes of Ancient Canids Suggest a European Origin of Domestic Dogs   +   Ancient DNA Analysis Affirms the Canid from Altai as a Primitive Dog    
    Ancient human genomes suggest three ancestral populations for present-day Europeans    
    Reconstructing the DNA Methylation Maps of the Neandertal and the Denisovan    

Ancient gene flow from early modern humans into Eastern Neanderthals


Excavating Neandertal and Denisovan DNA from the genomes of Melanesian individuals

    Lateraler gene transfer:    
    Bacterial phylogeny structures soil resistomes across habitats    
    Evolution of the F0 F1 ATP Synthase Complex in Light of the Patchy Distribution of Different Bioenergetic Pathways across Prokaryotes    
    Gene Transfers Shaped the Evolution of De Novo NAD+ Biosynthesis in Eukaryotes    
    Analysis of genomic rearrangements, horizontal gene transfer and role of plasmids in the evolution of industrial important Thermus species    

A bacterium that degrades and
assimilates poly(ethylene terephthalate)

    Eigene Vorschläge / own suggetions    


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