Publikationen

2015

• Conrad MP*, Piontek J* (*shared first authorship), Günzel D, Fromm M, Krug SM (2016, online 2015) Molecular basis of claudin-17 anion selectivity. Cell. Mol. Life Sci. 73(1): 185-200 (IF 5.7) [PubMed] [WebPage] [PDF] [Supplement] TP1+TP6+TP7+TPZ{FFEM}

2014

2013

• Bellmann C⁵, Schreivogel S, Günther R, Dabrowski S, Schümann M, Wolburg H, Blasig IE⁵ (2013) Highly conserved cysteines are involved in the oligomerization of occludin-redox dependency of the second extracellular loop. Antioxid. Redox Signal. 20(6): 855-867 (IF 7.7) [PubMed] [WebPage] [PDF] TP5

• Cording J, Berg J, Käding N, Bellmann C⁵, Tscheik C, Westphal JK³, Milatz S⁷, Günzel D⁷, Wolburg H, Piontek J⁶, Huber O³, Blasig IE⁵ (2013) Tight junctions: Claudins regulate the interactions between occludin, tricellulin and marvelD3, which, inversely, modulate the claudin oligomerization. J. Cell Sci. 126: 554-564 (IF 6.1) [PubMed] [WebPage] [PDF] [Supplement] TP5+TP7+TP6+TP3

• Doerfel MJ³, Westphal JK³, Krug SM^1,Z, Bellmann C⁵, Blasig IE⁵, Fromm M¹, Tauber R³, Huber O³ (2013) CK2-dependent phosphorylation of occludin regulates the interaction with ZO-proteins and tight junction integrity. Cell Commun. Signal. 11(1): 40 (IF 5.5) [PubMed] [WebPage] [PDF]  TP3+TP1+TP5+TPZ{2PI}

 

• Hering NA*², Richter JF¹* (*shared first authorship), Fromm A, Wieser A, Hartmann S, Günzel D⁷, Bücker R, Fromm M^1,Z, Schulzke JD°^2,Z (°corresponding author), Troeger H (2013) TcpC protein from E. coli Nissle improves epithelial barrier function involving PKCζ and ERK1/2 signalling in HT-29/B6 cells. Mucosal Immunol. 7(2): 369-378 (IF 7.0) [PubMed] [WebPage] [PDF] TP2+TP1+TP7+TPZ{2PI}

• Kirschner N⁹*, Rosenthal R¹* (*shared first authorship), Furuse M, Moll I, Fromm M^1,Z, Brandner JM⁹ (2013) Contribution of tight junction proteins to ion, macromolecule, and water barrier in keratinocytes. J. Invest. Dermatol. 133(5): 1161-1169 (IF 6.3) [PubMed] [WebPage] [PDF] [Supplement] For this paper, authors gained the Heinz-Maurer Award for Dermatological Science 2014 (10 T€)

TP9+TP1+TPZ

• Krug SM^1,Z, Amasheh M, Dittmann I, Christoffel I, Fromm M¹, Amasheh S¹ (2013) Sodium caprate as an enhancer of macromolecule permeation across tricellular tight junctions of intestinal cells. Biomaterials 34(1): 275-282 (IF 8.3) [PubMed] [WebPage] [PDF] TP1+TPZ

• Rachow S*, Zorn-Kruppa M* (*shared first authorship), Ohnemus U, Kirschner N⁹, Vidal-y-Sy S, von den Driesch P, Eberle J, Mildner M, Vettorazzi E, Rosenthal R¹, Moll I, Brandner JM⁹ (2013) Occludin is involved in adhesion, apoptosis, differentiation and Ca²⁺-homeostasis of human keratinocytes: implications for tumorigenesis. PLoS One 8(2): e55116 (IF 3.5) [PubMed] [WebPage] [PDF] TP9+TP1

• Schmid T, Bogdan M, Günzel D⁷ (2013) Discerning apical and basolateral properties of HT-29/B6 and IPEC-J2 cell layers by impedance spectroscopy, mathematical modeling and machine learning. PLOS One 8(7): e62913 (printed pages 1-12) (IF 3.5) [PubMed] [WebPage] [PDF] [Supplements, PDF] TP7

• Schmidt C, Lautenschlaeger C, Collnot EM, Schumann M, Bojarski C, Schulzke JD, Lehr CM, Stallmach A (2013) Nano- and microscaled particles for drug targeting to inflamed intestinal mucosa: a first in vivo study in human patients. J. Control. Release 165(2): 139-145 (IF 7.6) [PubMed] [WebPage] [PDF]

TP02

• Schulzke JD², Siegmund B, Günzel D⁷ (2013) New insights in intestinal secretion. Gut ###: ###-### (IF 13.3) (Commentary) [PubMed] [WebPage] [PDF] TP2+TP7

• Zakrzewski SS, Richter JF, Krug SM^1,Z, Jebautzke B, Lee IM, Rieger J, Sachtleben M, Bondzio A, Schulzke JD^2,Z, Fromm M^1,Z, Günzel D⁷ (2013) Improved cell line IPEC-J2, characterized as a model for porcine jejunal epithelium. PLOS One 8(11): e79643 (print pages 1-12) (IF 3.5) [PubMed] [WebPage] [PDF] [Supplements] TP7+TP1+TP2

  • Reviews

• Günzel D⁷, Yu AS (2013) Claudins and the modulation of tight junction permeability. Physiol. Rev. 93(2): 525-569 (IF 26.9) [PubMed] [WebPage] [PDF] TP7

• Tscheik C, Blasig IE⁵, Winkler L (2013) Trends in drug delivery through tissue barriers containing tight junctions. Tissue Barriers 1(2): ###-### (new journal, no IF yet) [WebPage] [Full text WebPage] [pending: PDF] TP5

2012

• Amasheh M, Luettig J, Amasheh S¹, Zeitz M², Fromm M¹, Schulzke JD² (2012) Effects of quercetin on the colonic cell culture model HT-29/B6 and rat intestine in vitro. Ann. N.Y. Acad. Sci. 1258: 100-107 (IF 3.2) [PubMed] [WebPage] [PDF] (Original paper) TP2+TP1

• Barmeyer C, Erko I, Fromm A, Bojarski C, Allers C, Moos V, Zeitz M², Fromm M¹, Schulzke JD² (2012) Ion transport and barrier function are disturbed in microscopic colitis. Ann. N.Y. Acad. Sci. 1258: 143-148 (IF 3.2) [PubMed] [WebPage] [PDF] (Original paper) TP2+TP1

• Batra A, Heimesaat MM, Bereswill S, Fischer A, Glauben R, Kunkel D, Scheffold A, Erben U, Kühl A, Loddenkemper C, Lehr HA, Schumann M, Schulzke JD², Zeitz M², Siegmund B (2012) Mesenteric fat – control site for bacterial translocation in colitis? Mucosal Immunol. 5(5): 580-591 (IF 7.0) [PubMed] [WebPage] [PDF] TP2

• Bautista-Garcia P, Reyes JL, Martin D, Namorado MC, Chavez-Munguia B, Soria-Castro E, Huber O³, Gonzalez-Mariscal L (2012) Zona occludens-2 protects against podocyte dysfunction induced by ADR in mice. Am. J. Physiol. Renal Physiol. ###: ###-### (IF 3.7) [PubMed] [WebPage] [PDF] TP3

• Breiderhoff T, Himmerkus N, Stuiver M, Mutig K, Will C⁴, Meij IC, Bachmann S, Bleich M, Willnow TE, Müller D⁴ (2012) Deletion of Cldn10 in the thick ascending limb impairs paracellular sodium permeability and leads to hypermagnesemia and nephrocalcinosis. Proc. Natl. Acad. Sci. USA 109(35): 14241-14246 (IF 9.7) [PubMed] [WebPage] [PDF w. Supplements] TP4

• Del Vecchio G*, Tscheik C* (*shared first authorship), Tenz K, Helms HC, Winkler L, Blasig R, Blasig IE⁵ (2012) Sodium caprate transiently opens claudin-5-containing barriers at tight junctions of epithelial and endothelial cells. Mol Pharm. 9(9): 2523-2533 (IF 4.8) [PubMed] [WebPage] [PDF] TP5

• Hackel D⁸, Krug SM¹, Sauer RS, Mousa SA, Böcker A, Pflücke D, Wrede EJ, Kistner K, Hoffmann T, Niedermirtl B, Sommer C, Bloch L, Huber O³, Blasig IE⁵, Amasheh S¹, Reeh PW, Fromm M^1,8, Brack A⁸, Rittner HL⁸ (2012) Transient opening of the perineurial barrier for analgesic drug delivery. Proc. Natl. Acad. Sci. USA 109(29): E2018-E2027 (IF 9.7) [PubMed] [WebPage] [PDF] TP8+TP1+TP3+TP5

• Hahne M, Zorn-Kruppa M, Guzman G, Brandner JM⁹, Haltner-Ukomado E, Wätzig H, Reichl S (2012) Prevalidation of a human cornea construct as an alternative to animal corneas for in vitro drug absorption studies. J. Pharm. Sci. (IF 3.0) 101(8): 2976-2888 [PubMed] [WebPage] [PDF] TP9

• Kaufmann R, Piontek J°⁶ (°corresponding author), Grüll F, Kirchgessner M, Rossa J, Blasig IE⁵, Cremer C. Visualization and quantitative analysis of tight junction networks using localization microscopy. Plos One 7(2): e31128 (print pages 1-9). doi:10.1371/journal.pone.0031128 (IF 4.4) [PubMed] [WebPage] [PDF] TP6+TP5

• Kirschner N⁹, Rosenthal R¹, Günzel D⁷, Moll I, Brandner JM⁹ (2012) Tight junctions and differentiation – a chicken or the egg question? Exp. Dermatol. 21(3): 171-175 (IF 4.2) [PubMed] [WebPage] [PDF] TP9+TP1+TP7

• Krug SM¹, Günzel D⁷, Conrad MP¹, Rosenthal R¹, Fromm A, Amasheh S¹, Schulzke JD², Fromm M¹ (2012) Claudin-17 forms tight junction channels with distinct anion selectivity. Cell. Mol. Life Sci. 69(16): 2765-2778 (IF 6.6) [PubMed] [WebPage] [PDF] [Supplement] TP1+TP7+TP2

• Markov AG, Kruglova NM, Fomina YA, Fromm M¹, Amasheh S¹ (2012) Altered expression of tight junction proteins in mammary epithelium after discontinued suckling in mice. Pflügers Arch. 463(2): 391-398 (IF 4.5) [PubMed] [WebPage] [PDF] TP1

• Ménard S, Lebreton C, Schumann M, Matysiak-Budnik T, Dugave C, Bouhnik Y, Malamut G, Cellier C, Allez M, Crenn P, Schulzke JD², Cerf-Bensussan N, Heyman M (2011) Paracellular versus transcellular intestinal permeability to gliadin peptides in active celiac disease. Am. J. Pathol. 180(2): 608-615 (IF 4.9) [PubMed] [WebPage] [PDF] TP2

• Rittner HL⁸, Amasheh S¹, Moshourab R, Hackel D⁸, Yamdeu RS, Fromm M¹, Stein C, Brack A⁸ (2012) Modulation of tight junction proteins in the perineurium to facilitate peripheral opioid analgesia. Anesthesiology 116(6): 1323-1334 (IF 5.4) [PubMed] [WebPage] [Full text via Ovid] TP8+TP1

• Rosenthal R*¹, Günzel D*⁷ (*shared first authorship), Finger C, Krug SM^1,Z, Richter JF, Schulzke JD², Fromm M¹, Amasheh S¹ (2012) The effect of chitosan on transcellular and paracellular mechanisms in the intestinal epithelial barrier. Biomaterials 33(9): 2791-2800 (IF 7.4) [PubMed] [WebPage] [PDF] [Supplement] TP1+TP7+TP2+TPZ

• Rossa J, Lorenz D, Ringling M, Veshnyakova A, Piontek J (2012) Overexpression of claudin-5 but not claudin-3 induces formation of transinteraction-dependent multilamellar bodies. Ann. N.Y. Acad. Sci. 1257: 59-66 (IF 3.2) [PubMed] [WebPage] [PDF] (Original paper) TP6  

• Rubelt MS, Amasheh S¹, Grobosch T, Stein C (2012) Liquid chromatography-tandem mass spectrometry for analysis of intestinal permeability of loperamide in physiological buffer. PLoS One 7(11): e48502 (print pages 1-8) (IF 4.1)

[PubMed] [WebPage] [PDF] TP1

• Rueckert C*, Castro V* (*shared first authorship), Gagell C, Dabrowski S, Schümann M, Krause E, Haseloff RF, Blasig IE (2012) Association between segments of zonula occludens proteins: Livecell FRET and mass spectrometric analysis. Ann. N.Y. Acad. Sci. 1257: 67-76 (IF 3.2) [PubMed] [WebPage] [PDF] (Original paper) TP5 

• Schumann M, Günzel D⁷, Buergel N, Richter JF, Troeger H, May C, Fromm A, Sorgenfrei D, Daum S, Bojarski C, Heyman M, Zeitz M², Fromm M¹, Schulzke JD² (2012) Cell polarity-determining proteins Par-3 and PP-1 are involved in epithelial tight junction defects in celiac disease. Gut 61(2): 220-228 (IF 10.1) [PubMed] [WebPage] [PDF] [Supplements] TP2+TP7+TP1

• Schumann M, Kamel S, Pahlitzsch ML, Lebenheim L, May C, Krauss M, Hummel M, Daum S, Fromm M¹, Schulzke JD² (2012) Defective tight junctions in refractory celiac disease. Ann. N.Y. Acad. Sci. 1258: 43-51 (IF 3.2) [PubMed] [WebPage] [PDF] (Original paper) TP2+TP1 

• Takahashi A*, Saito Y*, Kondoh M*° (*shared first authorship) (°corresponding author), Matsushita K, Krug SM¹, Suzuki H, Tsujino H, Li X, Aoyama H, Matsuhisa K, Uno T, Fromm M¹, Hamakubo T, Yagi K (2012) Creation and biochemical analysis of a broad-specific claudin binder. Biomaterials 33(12): 3464-3474 (IF 7.4) [PubMed] [WebPage with supplements] [PDF] TP1

• Veshnyakova A⁶, Krug SM¹, Mueller SL, Piontek J⁶, Protze J⁶, Fromm M¹, Krause G⁶ (2012) Determinants contributing to claudin ion channel formation. Ann. N.Y. Acad. Sci. 1257: 45-53 (IF 3.2) [PubMed] [WebPage] [PDF] (Original paper) TP6+TP1

• Veshnyakova A*⁶, Piontek J*°⁶ (*shared first authorship, °corresponding author⁾, Protze J, Waziri N, Heise I, Krause G⁶ (2012) Mechanism of Clostridium perfringens enterotoxin interaction with claudin-3/-4 suggests structural modifications of the toxin to target specific claudin. J. Biol. Chem. 287(3): 1698-1708 (IF 5.3) [PubMed] [WebPage] [Full text + supplements PDF] TP6

• Zwanziger D, Hackel D⁸, Staat C, Böcker A, Brack A⁸, Beyermann M, Rittner HL⁸, Blasig IE⁵ (2012) A peptidomimetic tight junction modulator to improve regional analgesia. Mol. Pharmaceut. 9(6): 1785-1794 (IF 5.4) [PubMed] [WebPage] [PDF] TP5+TP8

• Zwanziger D*, Staat C* (*shared first authorship), Andjelkovic AV, Blasig IE⁵ (2012) Claudin-derived peptides are internalized via specific endocytosis pathways. Ann. N.Y. Acad. Sci. 1257: 29-37 (IF 3.2) [PubMed] [WebPage] [PDF] (Original paper) TP5

  • Reviews

• Dörfel MJ³, Huber O³ (2012) A phosphorylation hotspot within the occludin C-terminal domain. Ann. N. Y. Acad. Sci. 1257: 38-44 (IF 3.2) [PubMed] [WebPage] [PDF] (Review) TP3

• Dörfel MJ³, Huber O³ (2012) Modulation of tight junction structure and function by kinases and phosphatases targeting occludin. J. Biomed. Biotech. 2012: Article ID 807356, 14 pages, doi:10.1155/2012/807356 (Review) (IF 2.4) [PubMed] [WebPage] [PDF] [Full text ePUB] TP3

• Günzel D⁷, Fromm M¹ (2012) Claudins and other tight junction proteins. Compreh. Physiol. (former Handbook of Physiology) 2(3): 1819-1852 [PubMed] [WebPage] [PDF] TP7+TP1

• Günzel D⁷, Zakrzewski S, Schmid T, Pangalos M, Wiedenhoeft J, Blasse C, Ozboda C, Krug SM¹ (2012) From TER to trans- and paracellular resistance: Lessons from impedance spectroscopy. Ann. N.Y. Acad. Sci. 1257: 142-151 (IF 3.2) [PubMed] [WebPage] [PDF] (Review) TP7+TP1

• Hackel D⁸, Brack A⁸, Fromm M¹, Rittner H⁸ (2012) Modulation of tight junction proteins in the perineurium for regional pain control. Ann. N.Y. Acad. Sci. 1257: 199-206 (IF 3.2) [PubMed] [WebPage] [PDF] (Review) TP8+TP1

• Hering NA², Fromm M¹, Schulzke JD² (2012) Determinants of colonic barrier function in inflammatory bowel disease and potential therapeutics. J. Physiol. 590(5): 1035-1044 (IF 5.1) [PubMed] [WebPage] [PDF] (Review) TP2+TP1

• Kirschner N⁹, Brandner JM⁹ (2012) Barriers and more: functions of tight junction proteins in the skin. Ann. N.Y. Acad. Sci. 1257: 158-166  (IF 3.2) [PubMed] [WebPage] [PDF] (Review) TP9

• Krug SM¹, Günzel D, Conrad MP¹, Lee IM, Amasheh S¹, Fromm M¹, Yu ASL (2012) Charge-selective claudin channels. Ann. N.Y. Acad. Sci. 1257: 20-28 (IF 3.2) [PubMed] [WebPage] [PDF] (Review) TP1+TP7

• Plöger S², Stumpff F, Penner GB, Schulzke JD², Gäbel G, Martens H, Shen Z, Günzel D⁷, Aschenbach JR (2012) Microbial butyrate and its role for barrier function in the gastrointestinal tract. Ann. N.Y. Acad. Sci. 1258: 52-59 (IF 3.2) [PubMed] [WebPage] [PDF] (Review) TP2+TP7

• Rosenthal R¹, Heydt MS, Amasheh M, Stein C, Fromm M¹, Amasheh S¹ (2012) Analysis of absorption enhancers in epithelial cell models. Ann. N.Y. Acad. Sci. 1258: 86-92 (IF 3.2) [PubMed] [WebPage] [PDF] (Review) TP1  

• Schulzke JD², Günzel D⁷, John LJ², Fromm M¹ (2012) Perspectives in tight junction research. Ann. N.Y. Acad. Sci. 1257: 1-19 (IF 3.2) [PubMed] [WebPage] [PDF] (Superinducing review) TP2+TP7+TP1

• Walther W, Petkov S, Kuvardina ON, Aumann J, Kobelt D, Fichtner I, Lemm M, Piontek J⁶, Blasig IE⁵, Stein U, Schlag PM (2012) Novel Clostridium perfringens enterotoxin suicide gene therapy for selective treatment of claudin-3- and -4-overexpressing tumors Gene Ther. 19(5): 494-503 (IF 4.5) [PubMed] [WebPage] [PDF] TP6+TP5

• Zhang J, Liss M, Wolburg H, Blasig IE⁵, Abdelilah-Seyfried S (2012) Involvement of caudins in zebrafish brain ventricle morphogenesis. Ann. N.Y. Acad. Sci. 1257: 193-198 (IF 3.2) [PubMed] [WebPage] [PDF] (Review) TP5

  • Editions

• Fromm M¹, Schulzke JD², Volume Editors (2012) Barriers and channels formed by tight junction proteins I. Ann. N.Y. Acad. Sci. vol. 1257: 1-206, 24 papers [WebPage]

• Fromm M¹, Schulzke JD², Volume Editors (2012) Barriers and channels formed by tight junction proteins II. Ann. N.Y. Acad. Sci. vol. 1258: 1-191, 24 papers [WebPage]

2011

• Bal MS*,Victor Castro V* (*shared first autorship), Piontek J⁶, Rueckert C, Walter JK, Shymanets A, Kurig B, Haase H, Nürnberg B, Blasig IE⁵ (2011) The hinge region of the scaffolding protein of cell contacts, zonula occludens protein regulates interacting with various signaling proteins. J. Cell. Biochem. 113(3): 934-945 (IF 3.1) [PubMed] [WebPage] [PDF] TP5+TP6

• Bücker R, Krug SM^1,Z, Rosenthal R¹, Günzel D⁷, Fromm A^Z, Zeitz M², Chakraborty T, Fromm M¹, Epple HJ, Schulzke JD² (2011) Aerolysin from Aeromonas hydrophila perturbs tight junction integrity and cell lesion repair in intestinal epithelial HT-29/B6 cells. J. Infect. Dis. 204 (8): 1283-1292 [PubMed] [WebPage] [PDF] TP2+TP1+TP7+TPZ

• Hering NA*², Andres S* (*shared first authorship), Fromm A^Z, van Tol EA, Amasheh M, Mankertz J, Fromm M¹, Schulzke JD² (2011) Transforming growth factor b, a whey protein component, strengthens the intestinal barrier by upregulating claudin-4 in HT-29/B6 cells. J. Nutr. 141(5): 783-789 [PubMed] [WebPage] [PDF] TP2+TP1

• Hering NA², Richter JF¹, Krug SM^1,Z, Günzel D⁷, Fromm A^Z, Bohn E, Rosenthal R¹, Bücker R, Fromm M^1,Z, Troeger H, Schulzke JD^2,Z (2011) Yersinia enterocolitica induces epithelial barrier dysfunction through regional tight junction changes in colonic HT-29/B6 cell monolayers. Lab. Invest. 91: 310-324 [PubMed] [WebPage] [PDF] [Supplement DOC] TP2+TPZ+TP7+TP1

• Kirschner N⁹, Haftek M, Niessen CM, Behne MJ, Furuse M, Moll I, Brandner JM⁹ (2011) CD44 regulates tight junction assembly and barrier function. J. Invest. Dermatol. 131(4): 932-943 [PubMed] [WebPage] [PDF] [Supplements] TP9

• Markov AG, Voronkova MA, Volgin GN, Yablonsky PK, Fromm M¹, Amasheh S¹ (2011) Tight junction proteins contribute to barrier properties in human pleura. Resp. Physiol. Neurobiol. 175(3): 331-335 [PubMed] [WebPage] [PDF] TP1

• Nielsen HL, Nielsen H, Ejlertsen T, Engberg J, Günzel D⁷, Zeitz M², Hering NA², Fromm M¹, Schulzke JD², Bücker R (2011) Oral and fecal Campylobacter concisus strains perturb barrier function by apoptosis induction in HT-29/B6 intestinal epithelial cells. Plos One 6(8): e23858 (print pages 1-8) [PubMed] [WebPage] [PDF] TP2+TP7+TP1

• Piontek J⁶, Fritzsche S, Cording J, Richter S, Hartwig J, Walter M, Yu D, Turner JR, Gehring C, Rahn HP, Wolburg H, Blasig IE⁵ (2011) Elucidating the principles of the molecular organization of heteropolymeric tight junction strands. Cell. Mol. Life Sci. 68(23): 3903-3918 [PubMed] [WebPage] [PDF] TP6+TP5

• Schulzke JD*², Andres S*, Amasheh M* (*shared first authorship), Fromm A, Günzel D⁷ (2011) Anti-diarrheal mechanism of the traditional remedy Uzara via reduction of active chloride secretion. PLoS One 6(3): e18107 (print 1-9) [PubMed] [WebPage] [PDF] TP2+TP7

• Stumpff F, Georgi MI, Mundhenk L, Rabbani I, Fromm M¹, Martens H, Günzel D⁷ (2011) Sheep rumen and omasum primary cultures and source epithelia: Barrier function aligns with expression of tight junction proteins. J. Exp. Biol. 214: 2871-2882 [PubMed] [WebPage] [PDF] [Supplement] TP7+TP1

• Werling AM, Doerflinger Y, Brandner JM⁹, Fuchs F, Becker JC, Schrama D, Kurzen H, Goerdt S, Peitsch WK (2011) Homo- and heterotypic cell-cell contacts in Merkel cells and Merkel cell carcinomas: heterogeneity and indications for cadherin switching. Histopathology 58(2): 286-303 [PubMed] [WebPage] [PDF] TP9 

  • Reviews

• Amasheh S¹, Fromm M¹, Günzel D⁷ (2011) Claudins of intestine and nephron - a correlation of molecular tight junction structure and barrier function. Acta Physiol. 201(1): 133-140 [PubMed] [WebPage] [PDF] (Review) TP1+TP7

• Blasig IE⁵, Bellmann C⁵, Cording J, del Vecchio G, Zwanziger D, Huber O³, Haseloff RF (2011) Occludin protein family: oxidative stress and reducing conditions. Antioxid. Redox Signal. 15(5): 1195-1219 [PubMed] [WebPage] [PDF for printing] [PDF with links] (Review) TP5+TP3

• Blasig IE⁵, Haseloff RF (2011) Tight junctions and tissue barriers. Antioxid. Redox Signal. 15(5): 1163-1166 (IF 8.2) (Editorial) [PubMed] [WebPage] [PDF for printing] [PDF with links] TP5

• John LJ², Fromm M¹, Schulzke JD² (2011) Epithelial barriers in intestinal inflammation. Antioxid. Redox Signal. 15(5): 1255-1270 [PubMed] [WebPage] [PDF for printing] [PDF with links] (Review) TP2+TP1

  • Dissertation

• Ploeger S² (2011) Die kurzkettige Fettsäure Butyrat stabilisiert die epitheliale Barrierefunktion des Darmes durch HNF-4alpha-abhängige Herabregulierung der Claudin-2-Expression. Dissertation, Biologie, Freie Universität Berlin, 17.06.11: Dr. rer. nat., Magna cum laude TP2

2010

• Amasheh M², Fromm A^Z, Krug SM^1,Z, Amasheh S¹, Andres S, Zeitz M², Fromm M¹, Schulzke JD² (2010) TNFa-induced and berberine-antagonized tight junction barrier impairment via tyrosine kinase, pAkt, and NFkB signaling. J. Cell Sci. 123(23): 4145-4155 [PubMed] [WebPage] [PDF] [Supplements] TP2+TP1+TPZ

• Becker S*, Wandel E* (*shared first authorship), Wobus M, Schneider R, Amasheh S¹, Sittig D, Kerner C, Naumann R, Hamann J, Aust G (2010) Overexpression of CD97 in intestinal epithelial cells of transgenic mice attenuates colitis by strengthening adherens junctions. Plos One [PubMed] [WebPage] [PDF] TP1

• Epple HJ, Allers K, Tröger H, Kühl A, Erben U, Fromm M¹, Zeitz M², Loddenkemper C*, Schulzke JD*², Schneider T* (*shared last authorship) (2010) Acute HIV infection induces mucosal infiltration with CD4+ and CD8+ T cells, epithelial apoptosis, and a mucosal barrier defect. Gastroenterology 139(4): 1289-1300 [PubMed] [WebPage] [PDF] [Supplement PDF] TP2+TP1

• Hillenbrand B, Günzel D⁷, Richter JF, Höhne, Schreier E, Schulzke JD², Mankertz J² ((2010) Norovirus non-structural protein p20 leads to impaired restitution of epithelial defects by inhibition of actin cytoskeleton remodelling. Scand. J. Gastroent. 45(11): 1307-1319 [PubMed] [WebPage] [PDF] TP2+TP7

• Kirschner N⁹, Haftek M, Niessen CM, Behne MJ, Furuse M, Moll I, Brandner JM⁹ (2010) CD44 regulates tight junction assembly and barrier function. J. Invest. Dermatol. 131(4): 932-943 [PubMed] [WebPage] [PDF] [Supplements] TP9

• Kirschner N⁹, Houdek P, Fromm M¹, Moll I, Brandner JM⁹ (2010) Tight junctions form a barrier in human epidermis. Eur. J. Cell Biol. 89(11): 839-842 (IF 3.6) [PubMed] [WebPage] [PDF] TP9+TP1

• Markov AG*, Veshnyakova A*⁶ (*shared first authorship), Fromm M¹, Amasheh M, Amasheh S¹ (2010) Segmental expression of claudin proteins correlates with tight junction barrier properties in rat intestine. J. Comp. Physiol. B 180(4): 591-598 [PubMed] [WebPage] [PDF] TP1+TP6

• Milatz S⁷, Krug SM^1,Z, Rosenthal R¹, Günzel D⁷, Müller D⁴, Schulzke JD^2,Z, Amasheh S*¹, Fromm M*^1,Z (*shared last authorship) (2010) Claudin-3 acts as a sealing component of the tight junction for ions of either charge and uncharged solutes. Biochim. Biophys. Acta Biomembr. 1798: 2048-2057 [PubMed] [WebPage] [PDF] TP1+TP7+TPZ+TP2+TP4

• Piehl C*, Piontek J*⁶ (*shared first authorship), Cording J, Wolburg H, Blasig IE⁵ (2010) Participation of the second extracellular loop of claudin-5 in paracellular tightening against ions, small and large molecules. Cell. Mol. Life Sci. 67(12): 2131-2140 [PubMed] [WebPage] [PDF] TP5+TP6

• Rosenthal R¹, Milatz S⁷, Krug SM^1,Z, Oelrich B, Schulzke JD^2,Z, Amasheh S¹, Günzel D⁷, Fromm M^1,Z (2010) Claudin-2, a component of the tight junction, forms a paracellular water channel. J. Cell Sci. 123(11): 1913-1921 [PubMed] [WebPage] [PDF] [Supplement] TP1+TP7+TPZ+TP2

• Schmid T, Günzel D⁷, Bogdan M (2010) Using an artificial neural network to determine electrical properties of epithelia. In: Diamantaras K, Duch W, Iliadis LS Eds., ICANN 2010, Part I, Lect. Notes Comput. Sci. 6352: 211-216 [26.07.10 In press] TP7

• Veshnyakova A⁶, Protze J⁶, Rossa J, Blasig IE⁵, Krause G⁶, Piontek J⁶ (2010) On the interaction of clostridium perfringens enterotoxin with claudins. Toxins 2(6): 1336-1356 [Abstract] [PDF] (review)  TP6+TP5

• Vockel M, Breitenbach U, Kreienkamp HJ, Brandner JM⁹ (2010) Somatostatin regulates tight junction function and composition in human keratinocytes. Exp. Dermatol. 19(10): 888-894 [PubMed] [WebPage] [PDF] TP9

• Westphal JK³, Dörfel MJ³, Krug SM¹, Cording JD, Piontek J⁶, Blasig IE⁵, Tauber R³, Fromm M¹, Huber O³ (2010) Tricellulin forms homomeric and heteromeric tight junctional complexes. Cell. Mol. Life Sci. 67(12): 2057-2068 [PubMed] [WebPage] [Supplement] [PDF] TP3+TP1+TP5+TP6

• Will C⁴, Breiderhoff T, Thumfart J, Stuiver M, Kopplin K⁴, Sommer K, Günzel D⁷, Querfeld U, Meij IC, Shan Q, Bleich M, Willnow TE⁴, Müller D⁴ (2010) Targeted deletion of murine Cldn16 identifies extra- and intrarenal compensatory mechanisms of Ca²⁺ and Mg²⁺ wasting. Am. J. Physiol. Renal Physiol.  298: F1152-F1161 [PubMed] [WebPage] [PDF] TP4+TP7

• Zhang J, Piontek J⁶, Wolburg H, Piehl C, Liss M, Otten C, Christ A, Willnow TE⁴, Blasig IE⁵, Abdelilah-Seyfried S (2010) Establishment of a neuroepithelial barrier by claudin-5a is essential for zebrafish brain ventricular lumen expansion. Proc. Natl. Acad. Sci. 107(4): 1425-1430 [PubMed] [WebPage] [PDF] TP5+TP6+TP4

  • Reviews

• Brandner JM*⁹, Haftek M*, Niessen CM* (*shared first/last authorship) (2010) Adherens junctions, desmosomes and tight junctions in epidermal barrier function. Open Dermatol. J. 4: 14-20 (DOI: 10.2174/1874372201004010014). [Abstract] [PDF] (Review) TP9

• Bücker R, Schumann M, Amasheh S¹, Schulzke JD² (2010) Claudins in intestinal function and disease. Curr. Top. Membr. 65: 195-227 [Directory] [WebPage] [PDF] (review / book chapter) TP2+TP1  

• Günzel D⁷, Krug SM^1,Z, Rosenthal R¹, Fromm M^1,Z (2010) Biophysical methods to study tight junction permeability. Curr. Top. Membr. 65: 39-78 [Directory] [WebPage] [PDF] (Review / book chapter) TP7+TPZ+TP1

• Haseloff RF, Piontek J⁶, Blasig IE⁵ (2010) The investigation of cis- and trans-interactions between claudins. Curr. Top. Membr. 65: 97-112 [Directory] [WebPage] [PDF] (Review / book chapter) TP5+TP6

• Kirschner N⁹, Bohner C, Rachow S, Brandner JM⁹ (2010) Tight junctions: is there a role in dermatology? Arch Dermatol Res. 302(7): 483-493 [PubMed] [WebPage] [PDF] (Review) TP9

  • Dissertationen

• Doerfel MJ (2010) Der Einfluss posttranslationaler Modifikationen auf die Funktion des Tight Junction-Proteins Occludin. Dissertation, Biochemie, Freie Universität Berlin. 21.06.10: Dr. rer. nat., Magna cum laude TP3

• Haisch L (2010) Barrierefunktion der Claudine des dicken aufsteigenden Astes der Henle-Schleife. Dissertation, Medizin, Charité Berlin. 15.01.10: Dr. med., Summa cum laude TP4+TP7

• Hering NA (2010) Die epitheliale Barriere als Zielstruktur pathogener und probiotischer Bakterien: Wirkmechanismen von Y. enterocolitica und E. coli Nissle. Dissertation, Biologie, Freie Universität Berlin, 14.12.10 Dr. rer. nat., Magna cum laude TP2

• Milatz S (2010) Funktionelle Charakterisierung des Tight Junction-Proteins Claudin-3 in Epithel- und Endothelzellen. Dissertation, Biologie, Humboldt-Universität zu Berlin. 07.05.10: Dr. rer. nat., Magna cum laude TP7+TP1

• Westphal JK (2010) Struktur, Funktion und Regulation des Tight Junction-Proteins Tricellulin. Dissertation, Biologie, Freie Universität Berlin. 12.02.10: Dr. rer. nat., Magna cum laude TP3

       Start der zweiten Förderperiode FOR 721/2: Januar 2010

2009

• Amasheh M, Grotjohann I, Amasheh S, Fromm A, Söderholm JD, Zeitz M, Fromm M, Schulzke JD (2009) Regulation of mucosal structure and barrier function in rat colon exposed to tumor necrosis factor alpha and interferon gamma in vitro: A novel model for studying the pathomechanisms of inflammatory bowel disease cytokines. Scand. J. Gastroent. 44: 1226-1235 [PubMed] [WebPage] [PDF] TP2+TP1

• Amasheh S, Dullat S, Fromm M, Schulzke JD, Buhr HJ, Kroesen AJ (2009) Inflamed pouch mucosa possesses altered tight junctions indicating recurrence of inflammatory bowel disease. Int. J. Colorectal Dis. 24(10): 1149-1156 [PubMed] [WebPage] [PDF] TP1+TP2

• Amasheh S*. Milatz S* (*shared first authorship), Krug SM, Bergs M, Amasheh M, Schulzke JD, Fromm M (2009, Epub 08.11.2008) Na⁺ absorption defends from paracellular back-leakage by claudin-8 upregulation. Biochem. Biophys. Res. Comm. 378: 45-50 [PubMed] [WebPage] [PDF]  TP1+TP2+(GU)

• Bücker R*, Troeger H* (*shared first authorship), Kleer J, Fromm M, Schulzke JD (2009) Arcobacter butzleri induces barrier dysfunction in intestinal epithelial cells. J. Infect. Dis. 200(5): 756-764 [PubMed] [WebPage] [PDF] TP2+TP1

• Günzel D, Amasheh S, Pfaffenbach S, Richter JF, Kausalya PJ, Hunziker W, Fromm M (2009) Claudin-16 affects transcellular Cl^- secretion in MDCK cells. J. Physiol. (Lond.) 587(15): 3777-3793 [PubMed] [WebPage] [PDF] [Supplement] (GU)+TP1

• Günzel D, Stuiver M, Kausalya PJ, Haisch L, Krug SM, Rosenthal R, Meij IC, Hunziker W, Fromm M, Müller D (2009) Claudin-10 exists in six alternatively spliced isoforms which exhibit distinct localization and function. J. Cell Sci. 122: 1507-1517 [PubMed] [WebPage] [PDF] TP4+TP1+(GU)

• Krug SM, Amasheh S, Richter JF, Milatz S, Günzel D, Westphal JK, Huber O, Schulzke JD, Fromm M (2009) Tricellulin forms a barrier to macromolecules in tricellular tight junctions without affecting ion permeability. Mol. Biol. Cell 20: 3713-3724 [PubMed] [WebPage] [PDF] [Supplement text] [Supplement video] TP1+TP2+TP3+Z+(GU)

• Krug SM, Fromm M, Günzel D (2009) Two-path impedance spectroscopy for measuring paracellular and transcellular epithelial resistance. Biophys. J. 97(8): 2202-2211 [PubMed] [WebPage] [PDF] [Supplement] TP1+(GU)

• Lohrberg D, Krause E, Schümann M, Piontek J, Winkler L, Blasig IE, Haseloff RF (2009) A strategy for enrichment of claudins based on their affinity to Clostridium perfringens enterotoxin. BMC Mol. Biol. 10(1): 61. [PubMed] [WebPage] [PDF] [Supplement] TP5+TP6

• Mankertz J*, Amasheh M* (*shared first authorship), Krug SM, Fromm A, Amasheh S, Hillenbrand B, Tavalali S, Fromm M, Schulzke JD (2009) TNFalpha up-regulates claudin-2 expression in epithelial HT-29/B6 cells via phosphatidylinositol-3-kinase signaling. Cell Tiss. Res. 33681): 67-77 [PubMed] [WebPage] [PDF] TP2+TP1

• Schillinger C, Boisguerin P, Krause G (2009) Domain Interaction Footprint: a multi-classification approach to predict domain-peptide interactions. Bioinformatics 25(13):1632-1639 [PubMed] [WebPage] [PDF] TP6

• Tapia R, Huerta M, Islas S, Avila-Flores A, Lopez-Bayghen E, Weiske J, Huber O, González-Mariscal L (2009) ZO-2 inhibits cyclin D1 expression and cell proliferation and exhibits changes in localization along the cell cycle. Mol. Biol. Cell  20(3): 1102-1117 [PubMed] [WebPage] [PDF] TP3

• Troeger H, Loddenkemper C, Schneider T, Schreier E, Epple HJ, Zeitz M, Fromm M, Schulzke JD (2009) Structural and functional changes of the duodenum in human norovirus infection. Gut 58: 1070-1077 [PubMed] [WebPage] [PDF]  TP2+TP1

• Winkler L, Gehring C, Wenzel A, Müller SL, Piehl C, Krause G, Blasig IE*, Piontek J* (*shared last authorship) (2009) Molecular determinants of the interaction between clostridium perfringens enterotoxin fragments and claudin-3. J. Biol. Chem. [Epub 08.05.09] [PubMed] [WebPage] [PDF] TP6

• Yu ASL, Cheng MH, Angelow S, Günzel D, Kanzawa SA, Schneeberger EE, Fromm M, Coalson RD (2009) Molecular basis for cation selectivity in claudin-2-based paracellular pores: Identification of an electrostatic interaction site. J. Gen. Physiol. 133(1): 111-127 [PubMed] [WebPage] [PDF]  TP1+(GU)

  • Reviews

• Fromm M, Schulzke JD, Volume Editors (2009) Molecular structure and function of the tight junction. Ann. N.Y. Acad. Sci. 1165: pp 1-346 [Contents and Full Papers] [Cover] TP1+TP2

• Amasheh M, Andres S, Amasheh S, Fromm M, Schulzke JD (2009) Barrier effects of nutritional factors. Ann. N.Y. Acad. Sci. 1165: 267-273 [PubMed] [WebPage] [PDF] TP1+TP2

• Amasheh S, Milatz S, Krug SM, Markov AG, Günzel D, Amasheh M, Fromm M (2009) Tight junction proteins as channel formers and barrier builders: claudin-2, -5, and -8. Ann. N.Y. Acad. Sci. 1165: 211-219 [PubMed] [WebPage] [PDF] TP1+TP2+(GU)

• Dörfel MJ, Westphal JK, Huber O (2009) Differential phosphorylation of occludin and tricellulin by CK2 and CK1. Ann. N.Y. Acad. Sci. 1165: 69-73 [PubMed] [WebPage] [PDF] TP3

• Fromm M, Krug SM, Zeissig S, Richter JF, Rosenthal R, Schulzke JD, Günzel D (2009) High resolution analysis of barrier function. Ann. N.Y. Acad. Sci. 1165: 74-81 [PubMed] [WebPage] [PDF] TP1+TP2+(GU)

• Günzel D, Haisch L, Pfaffenbach S, Krug SM, Milatz S, Amasheh S, Hunziker W, Müller D (2009) Claudin function in the thick ascending limb of Henle's loop. Ann. N.Y. Acad. Sci. 1165: 152-162 [PubMed] [WebPage] [PDF] TP4+TP1+(GU)

• Günzel D, Yu ASL (2009) Function and regulation of claudins in the thick ascending limb of Henle. Pflügers Arch. 458(1): 77-88 [PubMed] [WebPage] [PDF] (GU)

• Hering NA, Schulzke JD (2009) Therapeutic options to modulate barrier defects in inflammatory bowel disease. Dig. Dis. 27(4): 450-454 [PubMed] [PDF] TP2

• Krause G, Winkler L, Piehl C, Blasig I, Piontek J, Müller SL (2009) Structure and function of extracellular claudin domains. Ann. N.Y. Acad. Sci. 1165: 34-43 [PubMed] [WebPage] [PDF] TP6+(BL)

• Schulzke JD, Fromm M (2009) Tight junctions: Molecular structure meets function. Ann. N.Y. Acad. Sci. 1165: 1-6 [PubMed] [WebPage] [PDF] TP2+TP1

• Schulzke JD*, Ploeger S* (*shared first authorship), Amasheh M, Fromm A, Zeissig S, Troeger H, Richter JF, Bojarski C, Schumann M, Fromm M (2009) Epithelial tight junctions in intestinal inflammation. Ann. N.Y. Acad. Sci. 1165: 294-300 [PubMed] [WebPage] [PDF] TP2+TP1+Z

• Walter JK, Rückert C, Voss M, Müller SL, Piontek J, Blasig I (2009) The oligomerization of the coiled-coil domain of occludin is redox-sensitive. Ann. N.Y. Acad. Sci. 1165: 19-27 [PubMed] [WebPage] [PDF] TP6+(BL)

  • Dissertation

• Krug SM (2009) Tricellulin und seine Funktion in der trizellulären Tight Junction von Epithelzellen. Dissertation, Biochemie, Freie Universität Berlin. 30.11.09: Dr. rer. nat., Summa cum laude TP1

2008

• Amasheh M, Schlichter S, Amasheh S, Mankertz J, Zeitz M, Fromm M, Schulzke JD (2008) Quercetin enhances epithelial barrier function and increases claudin-4 expression in Caco-2 cells. J. Nutr. 138(6): 1067-1073 [PubMed] [WebPage] [PDF]  TP2+TP1

• Epple HJ, Schneider T, Troeger H, Kunkel D, Allers K, Moos V, Amasheh M, Loddenkemper C, Fromm M, Zeitz M, Schulzke JD (2009, Epub 04.11.2008) Impairment of the intestinal barrier is evident in untreated but absent in suppressively treated HIV-infected patients. Gut 58: 220-227 [PubMed] [WebPage] [PDF]  TP2+TP1

• {Günzel D, Yu ASL (2009, Epub 16.09.2008) Function and regulation of claudins in the thick ascending limb of Henle. Pflügers Arch. 458(1): 77-88 [PubMed] [WebPage] [PDF] }  (GU)

• Krause G, Winkler L, Mueller SL, Haseloff RF, Piontek J, Blasig IE (2008) Structure and function of claudins. Biochim. Biophys. Acta 1778(3): 631-645 [PubMed] [WebPage] [PDF]  TP6+(BL)

• Kroesen AJ, Dullat S, Schulzke JD, Fromm M, Buhr HJ (2008) Permanently increased mucosal permeability in patients with backwashileitis after ileoanal pouch for ulcerative colitis. Scand. J. Gastroent. 43(6): 704-711 [PubMed] [WebPage] [PDF]  TP2+TP1

• Piontek J, Winkler L, Wolburg H, Müller SL, Zuleger N, Piehl C, Wiesner B, Krause G, Blasig IE (2008) Formation of tight junction: determinants of homophilic interaction between classic claudins. FASEB J. 22(1): 146-158 [PubMed] [WebPage] [PDF]  TP6+(BL)

• Schumann M, Richter JF, Wedell I, Moos V, Zimmermann-Kordmann M, Schneider T, Daum S, Zeitz M, Fromm M, Schulzke JD (2008) Mechanisms of epithelial translocation of the a2-gliadin-33mer in celiac sprue. Gut 57(6): 747-754 [PubMed] [WebPage] [PDF]  TP2+TP1

  • Reviews

• Dörfel MJ, Huber O (2008) CSNK1A1 (casein kinase 1, alpha 1). Atlas Genet. Cyotgenet. Oncol. Haematol. URL: http://AtlasGeneticsOncology.org/Genes/CSNK1A1ID40168ch5q32.html  TP3

• Will C, Fromm M, Müller D (2008) Claudin tight junction proteins: novel aspects in paracellular transport. Periton. Dialysis Int. 28(6): 577-584 [PubMed] [PDF]  TP4+TP1+Z

2007

• Troeger H, Epple HJ, Schneider T, Wahnschaffe U, Ullrich R, Burchard GD, Jelinek T, Zeitz M, Fromm M, Schulzke JD (2007) Effect of chronic Giardia lamblia infection on epithelial transport and barrier function in human duodenum. Gut 56(3): 328-335 [PubMed] [WebPage] [PDF]  Comment in: Gut 2007 56(3): 316-317  TP2+TP1

• Zeissig S, Bürgel N, Günzel D, Richter JF, Mankertz J, Wahnschaffe U, Kroesen AJ, Zeitz M, Fromm M, Schulzke JD (2007) Changes in expression and distribution of claudin-2, -5 and -8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease. Gut 56(1): 61-72 [PubMed] [WebPage] [PDF]  TP2+Z+TP1+(GU)

  • Reviews

• Mankertz J, Schulzke JD (2007) Altered permeability in inflammatory bowel disease: pathophysiology and clinical implications. Curr. Opin. Gastroenterol. 23(4): 379-383 [PubMed] [WebPage/PDF]  TP2

• Markov AG, Veshnyakova A, Krug SM, Milatz S (2007) Expression of tight junction proteins in the epithelium of small intestine of the rat. Russ. J. Physiol. (Ross. Fiziol. Zh. Im. I. M. Sechenova) 93(9): 1043-1054 [PubMed]  TP1+TP6

      Start der ersten Förderperiode FOR 721/1: November 2006