DFG Research Training Group "TJ-Train", GRK 2318

Tight junctions and their proteins:
molecular features and actions in health and disease

Coordinator 
Prof. Jörg-Dieter Schulzke
Institute of Clinical Physiology
Charité - Universitätsmedizin Berlin
 , phone +49 30 450-514531
  Deputy Coordinator
Prof. Dorothee Günzel
Institute of Clinical Physiology
Charité - Universitätsmedizin Berlin
 , phone +49 30 450-514525

Scientific Coordinator
Priv.-Doz. Dr. Rita Rosenthal
 , phone +49 30 450-514527
  Secretary
Elisabeth Schultze
 , phone +49 30 450-514522

"TJ-Train" (GRK 2318) is a Research Training Group (Graduiertenkolleg) of the German Reseach Foundation (Deutsche Forschungsgemeinschaft, DFG), located in Berlin at sites of the Charité, MDC, and FMP. Its official beginning is on October, 2017.
We are organized in 12 work groups all of which have employed PhD doctoral students for the next three years.

Starting any time, we also offer doctoral thesis projects for medical students of the Charité. For financing the necessary interception of the MSM study, the DFG provides one-year student grants. Applications or just information via tj-train@charite.de or by direct contact to the respective principal investigator.

That's all about:

  • Very briefly: The tight junction (TJ) connects neighbouring epithelial or endothelial cells and is the central element of barrier function, as it controls paracellular passage of solutes and water. Whether the TJ simply increases tightness or selectively mediates permeability varies greatly in different tissues and is determined by the TJ protein composition. TJs underlie extensive extra- and intracellular signalling, but also regulate epithelial functions and cellular differentiation. Furthermore, numerous TJ proteins serve as receptors for certain pathogens. Thus, TJ proteins are involved in the pathogenesis of numerous diseases. Alterations in TJ composition and architecture may e.g. cause unwanted leak flux or antigen passage and may thus maintain disease activity or even directly trigger disease onset.

 
Projects and topics for theses 

     A:  Tight junction molecules, structure and function

Details

A1 

Dorothee Günzel*
Institute of Clinical Physiology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin

"Impedance spectroscopy of epithelial barrier properties"

Details

A2

Jörg Piontek1*, Gerd Krause2
1Institute of Clinical Physiology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin
2Structural Bioinformatics & Protein Design, Leibniz Research Institute of Molecular Pharmacology
(FMP), Berlin-Buch
"
Structure-based modification of Clostridium perfringens enterotoxin to target claudins"

Details

A3

Michael Fromm*, Jörg-Dieter Schulzke*
Institute of Clinical Physiology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin
"Claudin- and TAMP-mediated water transport"

Details

A4

Martin Lehmann, Volker Haucke*
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin-Buch
"High- and super-resolution imaging of tight junction components"

     B:  Tight junction development and regulation

Details

B1

Thomas Willnow*, Annabel Christ
Max-Delbrück-Centrum für Molekulare Medizin (MDC), Berlin-Buch
"Neuroepithelial barrier function in brain development"

Details

B2

Michael Hummel1, Britta Siegmund2*
1Molecularpathology Section at the Institute of Pathology, Charité, CCM
2
Medizinische Klinik m.S. Gastroenterologie, Infektiologie & Rheumatologie, Charité, CBF

"
Tracking a primary barrier defect in celiac disease"

Details

B3

Dominik Müller*
Klinik für Pädiatrie m.S. Nephrologie, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum
"
The magnesiome, an integrative view of magnesium regulation"

Details

B4

Kai Schmidt-Ott*
Medizinische Klinik mit Schwerpunkt Nephrologie und Internistische Intensivmedizin, Charité - Universitätsmedizin Berlin and Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
"Transcriptional integration of tight junction assembly in renal epithelial cells"

     C:  Tight junction modulation in disease

Details

C1

Jörg-Dieter Schulzke1*, Hanno Troeger2
1Institute of Clinical Physiology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin
2Med. Klinik m.S. Gastroenterologie, Infektiologie & Rheumatologie, CBF, Charité - Universitätsmedizin Berlin
"Toxin effects on paracellular intestinal barrier function"

Details

C2

Susanne Krug*, Michael Fromm*
Institute of Clinical Physiology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin
"Role of the tricellular TJ in inflammatory bowel diseases (IBD)"

Details C3

Michael Schumann, Britta Siegmund*
Medizinische Klinik m.S. Gastroenterologie, Infektiologie & Rheumatologie, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin
"
Epithelial dyspolarity in chronic intestinal inflammation"

Details

C4

Hans-Jörg Epple*, Thomas Schneider
Medizinische Klinik m.S. Gastroenterologie, Infektiologie & Rheumatologie, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin
"
Macromolecule uptake across the mucosa in HIV infection"

    * main GRK applicants

In addition, we offer two 40 h/month Studentische Hilfskraft positions: Details  

 

Impressum