Medizinische Klinik für Gastroenterologie, Infektiologie und Rheumatologie (einschl. Arbeitsbereich Ernährungsmedizin) CBF
Institute of Clinical Physiology / Div. of Nutritional Medicine

Head:  Prof. Dr. Jörg D. Schulzke

>>> Our recent publications: have a look <<< 

Our profile

   Physiology defines itself by a central question: "How does it work?"

For answering this question we apply several methods including molecular biology, electrophysiology, microbiology, biophysics, laser-scanning microscopy, and freeze-fracture electron microscopy

   We investigate all levels of the organism: molecules, cells, tissues, organs, and the whole body

Our approach is translational as it combines basic research with topics related to diseases of the intestines, kidneys, nerves, and skin


Main research topics are the tight junction and membrane channel molecules of the "intelligent borders of the body", the epithelia


We perform numerous collaborative projects with colleagues from clinical departments


The Institute of Clinical Physiology / Division of Nutritional Medicine is a unit within the Dept. of Gastroenterology, Rheumatology, and Infectious Diseases


News update


12.06.19 Online ahead of print  Rosenthal R, Günzel D, Piontek J, Krug SM, Ayala-Torres C, Hempel C, Theune D, Fromm M (2019) Claudin-15 forms a water channel through the tight junction with distinct function compared to claudin-2. Acta Physiol. (°IF 5.9) [PubMed] [WebPage] [PDF]

01.06.19 Appeared  Reinhold AK, Yang S, Chen JT, Hu L, Sauer RS, Krug SM, Mambretti E, Fromm M, Brack A, Rittner H (2019) Tissue plasminogen activator and neuropathy open the blood-nerve barrier with upregulation of miR-155-5p in male rats. Biochim. Biophys. Acta - Mol. Basis Dis. 1865(6): 1160-1169 (°IF 5.1)  [PubMed] [WebPage]

28.05.19 Paper accepted  Knöpfel T, Himmerkus N, Günzel D, Bleich M, Hernando N, Wagner C (2019) Paracellular transport of phosphate along the intestine. Am. J. Physiol. Gastointest. Liver Physiol. (°IF 3.3)

10.05.19 Online ahead of print  Ebel H, Fromm A, Günzel D, Fromm M, Schulzke JD (2019) Phospholipid effects on SGLT1-mediated glucose transport in rabbit ileum brush border membrane vesicles. Biochim. Biophys. Acta - Biomembranes ###: ###-### (°IF 3.4) [PubMed] [WebPage]

02.05.19 Appeared  Friedrich M, Gerbeth L, Gerling M, Rosenthal R, Steiger K, Weidinger C, Keye J, Hao W, Schmidt F, Weichert W, Siegmund B*, Glauben R* (*shared last authorship) (2019) HDAC inhibitors promote intestinal epithelial regeneration via autocrine TGFβ1 signalling in inflammation. Mucosal Immunol. 12(3): 656-667 (°IF 7.4) [PubMed] [WebPage] [PDF]

09.04.19 Textbook chapter appeared Fromm M (2019) Chapter 3: "Transport in Membranen und Epithelien" [Transport in membranes and epithelia], In: Physiologie des Menschen. Brandes R, Lang F, Schmidt RF (), eds., 32nd edition, Springer-Verlag, Berlin Heidelberg. ISBN 978-3-662-56467-7, p 22-37 and p 1006-1009 [Publisher's ad]



Research topics

Clinical Physiology

External collaborations
(*PhD) (°MD) (GRK)
  Staff Doctoral students  (*PhD) (°MD) (GRK)
Tight junctions and their proteins
- Claudin family
- TAMP family
- Angulin family

DFG Research Training Group 
"TJ-Train" GRK 2318

(Progenitor: DFG Research Unit 721)

  Jörg Schulzke,
Michael Fromm,
Dorothee Günzel,
Susanne Krug,
Luca Meoli,
Jörg Piontek,
Rita Rosenthal
  Surgery: Nina Hering
Physiology, Univ. Kiel: Susanne Milatz
Vet. Physiology FU Berlin:
Salah Amasheh
Neurosurgery: Kinga Blecharz-Lang
Univ. partnership Berlin - St. Petersburg: Alexander Markov
Molecular structure
- Molec. structure of single claudins
- Molec. arrangement of heteromers
- Molec. structure of tricellulin
  Jörg Piontek,
Dorothee Günzel,
Susanne Krug
Miriam Eichner*,
Caroline Hempel*,
Laura-Sophie Beier* (A2)
FMP Berlin-Buch: Gerd Krause
Physiology, Univ. Kiel:
Susanne Milatz

Functional properties
- Barriers and ion channels
- Water channels
- Tricellular tight junction

  Michael Fromm,
Dorothee Günzel,
Susanne Krug,
Rita Rosenthal
Carlos Ayala-Torres* (A3)
Dian Theune°
Anatomy, Univ. Jena: Jan Richter
Diseases and pathologies
- Inflammatory bowel diseases
- Cytokines & interleukins

- Epithelial cancers

DFG Transregio-SFB TRR 241

  Jörg Schulzke,
Roland Bücker,
Susanne Krug
Jia-Chen Hu* (C2)
Karem Awad°
Alice Itzlinger°
Tatjana Zejc
Franziska Weiß* (B06)
Gastroenterology: Michael Schumann, Christian Bojarski, Hans-Jörg Epple, Hanno Troeger, Deborah Delbue da Silva* (C3), Carolin Grünhagen* (C4), Hannah Lutz° (C4)
Independent doctor: Christian Barmeyer
MDC: Izabela Kowalczyk* (B1)
Pathogens and TJ

BMBF Consortium "PAC-CAMPY"

  Jörg Schulzke,
Roland Bücker,
Dorothee Günzel
Eduard Butkevych°
Fábia Lobo de Sá* (IP8)
Praveen Nattramilarasu* (C1)
Luisa Reetz°
Gastroenterology: Hans-Jörg Epple, Hanno Troeger
Surgery: Nina Hering
- Diets and nutrients
- Celiac disease
  Jörg Schulzke,
Rita Rosenthal,
Roland Bücker
  Gastroenterology: Michael Schumann
Independent researcher: Silke Zakrzewski

Pathol.+Gastroent.: Danielle Cardoso da Silva* (B2)
- Claudins of the kidney
- FHHNC,  - Ca2+,  - Mg2+
  Dorothee Günzel,
Susanne Krug,

Luca Meoli
  Pediatric Nephrology: Dominik Müller, Tilman Breiderhoff, Murat Seker* (B3)
: Janna Leiz* (B4), Alexander Holler° (B4)
Anatomy: Kerim Mutig
Physiology, Univ. Kiel:
Susanne Milatz

- Macromolecule permeation
- Drug absorption enhancers
  Susanne Krug,
Michael Fromm,
Rita Rosenthal
Carolina Czichos° Anatomy, Univ. Jena: Jan Richter
Topics except TJ
- Epithelial Na+ channel (ENaC)
- Physiology of the eye
  Jörg Schulzke,
Michael Fromm
Rita Rosenthal
  Independent doctor: Christian Barmeyer
- Impedance spectroscopy

- Electron microscopy
  Dorothee Günzel,
Susanne Krug,
Jörg Piontek
In-Fah Lee
Roman Mannweiler* (A1) Anatomy: Sebastian Bachmann
FMP: Hannes Gonschior*

Overview:  Staff   Research topics   News blog 
Doctoral fellows
    Alumni doctoral fellows  

  Publications:  The Institute   Schulzke   Fromm  
 Günzel   Bücker   Krug   Meoli   Piontek   Rosenthal  


The institute was founded in 1969 and chaired until 1995 by Klaus Hierholzer ( 2007), followed by Michael Wiederholt. (1995-2002) and Michael Fromm (2002-2014, now appointed as Charité senior professor). Retired professors are Ulrich Hegel and Hans Ebel. Present head is Jörg D.Schulzke.


The main building of the Campus Benjamin Franklin (CBF)
of the Charité - Universitätsmedizin Berlin, a joint institution of the
Freie Universität Berlin
and the Humboldt-Universität Berlin
   University Hospital Benjamin Franklin (UKBF) pics
Address:    Institute of Clinical Physiology / Div. Nutritional Medicine
Charité, Campus Benjamin Franklin
Hindenburgdamm 30
12203 Berlin (Steglitz), Germany
  Google Maps
Public transportation: Subway (U-Bahn "U9") or local train (S-Bahn "S1") 
to "Rathaus Steglitz", then change for bus 285 or M85, 
exit bus stop "Universitätsklinikum Benjamin Franklin"  Local map
Fares: Single ticket for 2 hrs, unlimited changes: "AB" 2.80 Euro
or, ONLY bus 285 or M85 from Rathaus Steglitz: "Kurzstrecke" 1.70 Euro  
Location within the hospital: Elevator No. 13, 14, 15 or stairs "G", 5th floor
Professor Dr. med. Jörg D. Schulzke
Phone direct:
Phone Schulzke via secretary:
+49 30 450-514531
+49 30 450-514522
Phone of secretary:
Elisabeth Schultze
+49 30 450-514522
FAX: +49 30 450-514962
Representative of the German Research Foundation
(DFG) at the Charité: Prof. Michael Fromm
  Hints & requirements for applying at the DFG