Medizinische Klinik für Gastroenterologie, Infektiologie und Rheumatologie (einschl. Arbeitsbereich Ernährungsmedizin) CBF
Institute of Clinical Physiology / Div. of Nutritional Medicine

Head:  Prof. Dr. Jörg D. Schulzke

>>> Our recent publications: have a look <<< 

Our profile

   "Physiology" we define by a central question: "How does it work?"
  

For answering this question we apply several methods including molecular biology, electrophysiology, microbiology, biophysics, laser-scanning microscopy, and freeze-fracture electron microscopy

   We investigate all levels of the organism: molecules, cells, tissues, organs, and the whole body
  

Our approach is translational as it combines basic research with topics related to diseases of the intestines, kidneys, nerves, and skin

  

Main research topics are the tight junction and membrane channel molecules of the "intelligent borders of the body", the epithelia

  

We perform numerous collaborative projects with colleagues from clinical departments

  

The Institute of Clinical Physiology / Division of Nutritional Medicine is a unit within the Dept. of Gastroenterology, Rheumatology, and Infectious Diseases

   

 

News update    Archive

 

20.10.20 Accepted  Hu JCE, Bojarski C, Branchi F, Fromm M, Krug SM (2020) Leptin downregulates angulin-1 in active Crohn's disease via STAT3. Int. J. Mol. Sci. (Special Issue “Pathophysiology in Colonic Diseases”) 21(21): 7824 (17 pages) (°IF 4.6) [PubMed] [WebPage] [PDF] [Supplement]

28.09.20 Major instrumentation accepted by DFG: STED superresolution confocal microscope, 700 T€, corresponding applicant Günzel D

24.09.20 DFG grant accepted  Rittner HL und Krug SM, Project 7 "Neuropathic pain resolution by nerve barrier sealing via endogenous netrin-1", in: DFG Klinische Forschungsgruppe (KFO 5001), coordinators Sommer C and Rittner HL (Würzburg) "Peripheral mechanisms of pain and their resolution". Berlin: 1 PhD student

01.09.20 Published  Meoli L, Günzel D (2020) Channel functions of claudins in the organization of biological systems. BBA - Biomembranes 1862(9): 183344 (18 pages) (°IF 3.5) [Part of Special Volume "The vertebrate epithelial apical junctional complex", Hervé JC ed.] [PubMed] [WebPage] [PDF] [Supplementary Fig. S1]

 


Research topics

Clinical Physiology

External collaborations
(*PhD) (°MD) (GRK)
  Staff Doctoral students  (*PhD) (°MD) (GRK)
Tight junctions and their proteins
- Claudin family
- TAMP family
- Angulin family

DFG Research Training Group 
"TJ-Train" GRK 2318

(Progenitor: DFG Research Unit 721)

  Jörg Schulzke,
Michael Fromm,
Dorothee Günzel,
Susanne Krug,
Luca Meoli,
Jörg Piontek,
Rita Rosenthal
  Surgery: Nina Hering
Physiology, Univ. Kiel: Susanne Milatz
Vet. Physiology FU Berlin:
Salah Amasheh
Neurosurgery: Kinga Blecharz-Lang
Molecular structure
- Molec. structure of single claudins
- Molec. arrangement of heteromers
- Molec. structure of tricellulin
  Jörg Piontek,
Dorothee Günzel,
Susanne Krug
Miriam Eichner*,
Caroline Hempel*,
Ayk Waldow* (A2), Laura-Sophie Beier* (A2)
FMP Berlin-Buch: Gerd Krause
Physiology, Univ. Kiel:
Susanne Milatz

Functional properties
- Barriers and ion channels
- Water channels
- Tricellular tight junction

  Michael Fromm,
Dorothee Günzel,
Susanne Krug,
Rita Rosenthal
Fabian Martinez-Perafan* (A3), Carlos Ayala-Torres* (A3),
Dian Theune°
 
Diseases and pathologies
- Inflammatory bowel diseases
- Cytokines & interleukins

- Epithelial cancers

DFG Transregio-SFB TRR 241

  Jörg Schulzke,
Roland Bücker,
Susanne Krug
Lena Voges* (C2)
Jia-Chen Hu* (C2)
Karem Awad°
Alice Itzlinger°
Tatjana Zejc
°
Franziska Weiß* (B06)
Gastroenterology: Michael Schumann, Christian Bojarski, Hans-Jörg Epple, Hanno Troeger, Deborah Delbue da Silva* (C3), Carolin Grünhagen* (C4), Hannah Lutz° (C4)
Independent doctor: Christian Barmeyer
MDC: Izabela Kowalczyk* (B1)
Pathogens and TJ

BMBF Consortium "PAC-CAMPY"

  Jörg Schulzke,
Roland Bücker,
Dorothee Günzel
Eduard Butkevych°,
Fábia Lobo de Sá* (IP8),
Martina Schneemann* (C1), Praveen Nattramilarasu* (C1),
Luisa Reetz°
Gastroenterology: Hans-Jörg Epple, Hanno Troeger
Surgery: Nina Hering
- Diets and nutrients
- Celiac disease
  Jörg Schulzke,
Rita Rosenthal,
Roland Bücker
  Gastroenterology: Michael Schumann
Independent researcher: Silke Zakrzewski

Pathol.+Gastroent.: Danielle Cardoso da Silva* (B2)
 
- Claudins of the kidney
- FHHNC,  - Ca2+,  - Mg2+
  Dorothee Günzel,
Susanne Krug,

Luca Meoli
  Pediatric Nephrology: Dominik Müller, Tilman Breiderhoff, Murat Seker* (B3)
Nephrology
: Janna Leiz* (B4), Alexander Holler° (B4)
Anatomy: Kerim Mutig
Physiology, Univ. Kiel:
Susanne Milatz

 
- Pain reduction in peripheral nerve

DFG Klin. Forschungsgr. KFO 5001

 

  Susanne Krug n.n.* (P7) Anesthesiology Würzburg: Heike Rittner
Mechanisms
- Macromolecule permeation
- Drug absorption enhancers
  Susanne Krug,
Michael Fromm,
Rita Rosenthal
Carolina Czichos° Anatomy, Univ. Jena: Jan Richter
Topics except TJ
- Epithelial Na+ channel (ENaC)
- Physiology of the eye
  Jörg Schulzke,
Michael Fromm
,
Rita Rosenthal
  Independent doctor: Christian Barmeyer
Methods
- Impedance spectroscopy

- Electron microscopy

- Organoid culture
  Dorothee Günzel,
Susanne Krug,
Jörg Piontek
,
In-Fah Lee
Saeed Khomeijani Farahani* (A1), Roman Mannweiler* (A1)
Franziska Weiß* (B06)
Anatomy: Sebastian Bachmann
FMP: Hannes Gonschior*
(A4)
 

Overview:  Staff   Research topics   News blog 
Doctoral fellows
    Alumni doctoral fellows  

  Publications:  The Institute   Schulzke   Fromm  
 Günzel   Bücker   Krug   Meoli   Piontek   Rosenthal  

 
History

The institute was founded in 1969 and chaired until 1995 by Klaus Hierholzer ( 2007), followed by Michael Wiederholt. (1995-2002) and Michael Fromm (2002-2014, now appointed as Charité senior professor). Retired professors are Ulrich Hegel and Hans Ebel. Present head is Jörg D.Schulzke.
 

Address

The main building of the Campus Benjamin Franklin (CBF)
of the Charité - Universitätsmedizin Berlin
   University Hospital Benjamin Franklin (UKBF) pics
Address:    Institute of Clinical Physiology / Div. Nutritional Medicine
Charité, Campus Benjamin Franklin
Hindenburgdamm 30
12203 Berlin (Steglitz), Germany
  Google Maps
Public transportation: Subway (U-Bahn "U9") or local train (S-Bahn "S1") 
to "Rathaus Steglitz", then change for bus 285 or M85, 
exit bus stop "Universitätsklinikum Benjamin Franklin"  Local map
Fares: Single ticket for 2 hrs, unlimited changes: "AB" 2.80 Euro
or, ONLY bus 285 or M85 from Rathaus Steglitz: "Kurzstrecke" 1.70 Euro  
   
Head:
 
Professor Dr. med. Jörg D. Schulzke
joerg.schulzke@charite.de
Phone direct:
Phone Schulzke via secretary:
+49 30 450-514531
+49 30 450-514522
Secretary:
 
Phone of secretary:
Andreas Jantke
andreas.jantke@charite.de
+49 30 450-514522
FAX: +49 30 450-514962
   

Representative of the German Research Foundation
(DFG) at the Charité, Seniorprofessor Dr. Michael Fromm:

Hints and advice