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Institute of Clinical Physiology

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Grants
 German Research Foundation (DFG) 

Münze

  Current projects, most recent first

2018 - 2022

Krug, Schulzke

Project B06 "Interplay of the impaired tight junction and the subjacent immune cells in IBD", in:
DFG Transregio Collaborative Research Center (TRR 241), coordinators C. Becker (Erlangen) and B. Siegmund (Berlin) "Immune-epithelial communication in inflammatory bowel diseases"
2018 - 2021

Krug, Rittner

DFG Research Grant (KR 3807/7-1) "Neuropathic pain resolution by nerve barrier sealing and netrin-1", together with Heike Rittner, Würzburg (RI 817/12-1)
2017 Bachmann (Anatomie) Large equipment DFG  Field emission scanning electron microscope (FESEM). In the user group
Fromm, Krug, Piontek: "Paracellular versus transcytotic macromolecule passage / Organization of claudins in nanodomains"
2017 - 2022 Schulzke

Coordinator, (deputy coordinator Günzel)
DFG Research Training Group (GRK 2318) "Tight junctions and their proteins: molecular features and actions in health and disease (TJ-Train)", Summary

2017 - 2022 Günzel

     therein: Project A1, "Impedance spectroscopy of epithelial barrier properties"

2017 - 2022 Piontek, Krause

     therein: Project A2, "Structure-based modification of Clostridium perfringens enterotoxin to target claudins"

2017 - 2022 Fromm, Schulzke

     therein: Project A3, "Claudin- and TAMP-mediated water transport"

2017 - 2022 Schulzke, Troeger

     therein: Project C1, "Toxin effects on paracellular intestinal barrier function"

2017 - 2022 Krug, Fromm

     therein: Project C2, "Role of the tricellular tight junction in inflammatory bowel diseases (IBD)"

2017 - 2020 Bücker, Schulzke

Project IP8 "Strengthening the intestinal barrier in Campylobacter infection", in
BMBF Consortium "Preventing and combating Campylobacter infections: On track towards a One Health approach (PAC-CAMPY)“, Coordinator Thomas Alter, VetMed FU Berlin

2017 - 2020 Schulzke

DFG Research Grant (Schu 559/11-3) "Mechanismen epithelialer Barrierestörung bei gastrointestinalen Infektionen"

2016 - 2019 Günzel DFG Research Grant (GU 447/14-1) "Functional interaction of claudins in renal ion transport"
2015 - 2019 Aebischer, Schulzke Project B3 "Giardia duodenalis – Dendritic cell interaction and intestinal barrier function", in:
DFG Research Training Group
(GRK 2046/1) Coordinator S. Hartmann: "Parasite infections: From experimental models to natural systems"
2015 - 2018 Piontek, Krause DFG Resarch Grant (PI-837/4-1) "Molecular architecture of claudin-based tight junction strands and paracellular ion channels"

  Finished projects, since 2000

2014 - 2017 Fromm DFG Research Grant (FR 652/12-1) "Tight junction protein-mediated water transport"
2014 - 2016 Schulzke

DFG Research Grant (Schu 559/11-2) "Mechanismen epithelialer Barrierestörung bei gastrointestinalen Infektionen"

2016 Schulzke International Conference "Tight junctions and their proteins", Berlin, 08.09.16 - 10.09.16 (Schu 559/13-1)
2014 Schulzke, Siegmund

DFG Major Research Instrumentation (INST 335/515-1) Confocal laser-scanning microscope

2010 - 2014 Fromm, Schulzke

Project B2 "Paracellular intestinal barrier - effects of probiotics and feed additives", in:
DFG Collaborative Research Center 852 (SFB 852/1), Coordinator J. Zentek: "Nutrition and intestinal microbiota - host interaction in the pig"

2010 - 2012 Fromm

Coordinator:
DFG Research Unit 721
(FOR 721/2) "Molecular structure and function of the tight junction"

2010 - 2012 Fromm, Amasheh

Project 1 "Characterization of tight junction proteins as barrier or channel formers", in:
DFG Research Unit 721 (FOR 721/2) "Molecular structure and function of the tight junction"

2010 - 2012 Günzel

Project 7 "Renal claudins and their interactions", in:
DFG Research Unit 721 (FOR 721/2) "Molecular structure and function of the tight junction"

2010 - 2012 Rittner, Brack, Fromm

Project 8 "Tight junction proteins as permeability regulators of the perineurium and of the antinociception perineurallly applied drugs", in:
DFG Research Unit 721
(FOR 721/2) "Molecular structure and function of the tight junction"

2010 - 2012 Fromm, Schulzke, Krug

Project Z "Freeze fracture electron microscopy" und two-path impedance spectroscopy, in:
DFG Research Unit 721 (FOR 721/2) "Molecular structure and function of the tight junction"

2009 - 2012 Aust, Amasheh,
Fromm

DFG Research Grant (AU 132/7-1 and AM 141/4-1) "Meaning of CD97 in experimental colitis and ulcerative colitis: functional characterization of the molecule in intestinal epithelial cells"

2011 - 2012 Amasheh DFG Grant (AM 141/5-1), program Initiation and enhancement of bilateral cooperation. Joint project and mutual research stays of Prof. A. Markov, St. Peterburg, Russia, in Berlin and of S. Amasheh in St. Petersburg
2011 - 2012 Fromm, Krug DFG Grant (FR 852/11-1), program Initiation and enhancement of bilateral cooperation. Joint project and research stays in Berlin of Dmitry Stepanov, St. Peterburg, Russia
2011 - 2012 Krug DFG Grant (KR 3807/1-1) program Initiation and enhancement of bilateral cooperation. Joint project and research stay with Prof. Jerrold R. Turner, Chicago IL, USA
2008 - 2010 Günzel, Fromm

DFG Research Grant (GU 447/11-1) "Barrier and channel properties of claudins in the renal diluting segment and distal nephron"

2006 - 2009 Fromm

Coordinator:
DFG Research Unit 721
(FOR 721/1) "Molecular structure and function of the tight junction"

2006 - 2009 Amasheh, Fromm

Project 1 "Characterization of tight junction proteins as barrier or channel formers", in:
DFG Research Unit 721 (FOR 721/1, TP 1) "Molecular structure and function of the tight junction"

2006 - 2009 Fromm, Schulzke

Project Z "Freeze fracture electron microscopy; general duties", in:
DFG Research Unit 721 (FOR 721/1, TP Z) "Molecular structure and function of the tight junction"

2007 - 2008 Fromm DFG Visiting Professorship (FR 652/8-1) "Tight junction proteins in surface and crypt epithelia of leaky and tight segments of the intestine", Prof. A. Markov, St. Petersburg, Russia
2005 - 2007 Fromm, Amasheh DFG Research Grant (FR 652/4-3) "Regulation and function of tight junction und channel proteins in the colon"
2004 - 2006 Schulzke, Fromm, Epple, Mankertz Project 3 "Epithelial barrier defects after small intestinal infections and systemic infections with intestinal symptoms", in:
DFG Clinical Research Unit 104 (KFO 104/2), Coordinator M. Zeitz: "Immune pathogenesis and intervention strategies in mucosal infections"
2003 - 2005 Fromm, Gitter, Schulzke Project 8 "Characterisation of intestinal bacterial translocation by confocaler fluorescence microscopy", in:
DFG Research Training Group 276 (GRK 276/3), Coordinator B. Wiedenmann: "Cellular signal recognition and tranduction"
2002 - 2003 Fromm DFG Research Grant (Fr 652/4-2) "Regulation and function of tight junction und channel proteins in the colon"
2001 - 2003 Schulzke, Epple, Fromm Project 3 "Epithelial barrier defects after small intestinal infections and systemic infections with intestinal symptoms", in:
DFG Clinical Research Unit 104 (KFO 104/1-1), Coordinator M. Zeitz: "Immune pathogenesis and intervention strategies in mucosal infections"
2000 - 2004 Günzel DFG Research Grant (GU 447/6-1) "Regulation of the intracellular Mg2+ concentration in identified neurons of the leech (Hirudo medicinalis)"
2000 - 2002 Fromm, Gitter, Schulzke Project 8 "Cytokine-induced intestinal barrier defects caused by apoptosis - conductance scanning and immune fluorescence microscopy", in:
DFG Research Training Group 276 (GRK 276/2), Coordinator B. Wiedenmann: "Cellular signal recognition and tranduction"
2000 - 2002 Fromm DFG Research Grant (Fr 652/4-1) "Regulation and function of tight junction und channel proteins in the colon"