Institute of Clinical Physiology

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    > Dorothee Guenzel

 
 
Prof. Dr. rer. nat.
Dorothee Günzel
Deputy Head of the Institute of Clinical Physiology


 

e-mail   dorothee.guenzel@charite.de
phone   +49 30 450-514525
FAX   +49 30 450-514962
Orcid ID   0000-0002-7998-7164  

Research topics

- Tight junctions and their proteins
- Claudin-10a and -10b

- Claudins of the kidney
- FHHNC (Ca2+Mg2+)

- Two-path impedance spectroscopy
- "TJ-Train", project A1: Impedance spectroscopy of epithelial barrier properties

- Conductance scanning

- Magnesium transport

- Intracellular Magnesium (see below)

Publications

   

Grants German Research Foundation (DFG)

2017 - 2022 Günzel Deputy Coordinator
DFG Research Training Group
(GRK 2318) "Tight junctions and their proteins: molecular features and actions in health and disease (TJ-Train)"
2017 - 2022 Günzel

Project A1, "Impedance spectroscopy of epithelial barrier properties", in:
DFG Research Training Group (GRK 2318) "Tight junctions and their proteins: molecular features and actions in health and disease (TJ-Train)"

2016 - 2019 Günzel DFG Research Grant (GU 447/14-1) "Functional interaction of claudins in renal ion transport"
2010 - 2012 Günzel

Project 7 "Renal claudins and their interactions", in:
DFG Research Unit 721 (FOR 721/2) "Molecular structure and function of the tight junction"

2008 - 2010 Günzel,
Fromm

DFG Research Grant (GU 447/11-1) "Barrier and channel properties of claudins in the renal diluting segment and distal nephron"

2000 - 2004 Günzel DFG Research Grant (GU 447/6-1) "Regulation of the intracellular Mg2+ concentration in identified neurons of the leech (Hirudo medicinalis)"

CV

1981 - 1988 Study of Biology, University of Constance, Germany
1987 - 1988 Diploma thesis "Correlation of histochemical, morphological, and electrophysiological properties of opener and closer muscle fibers of crayfish walking legs", supervision Prof. Rathmayer, University of Constance
1988 - 1992 PhD doctoral thesis, "The 'catch-like' effect of arthropod muscle contraction", supervision Prof. Rathmayer, University of Constance
1992 * daughter Carolin
1992 - 1999 Researcher, Dept. of Neurobiology, University of Duesseldorf
2000 Visiting Assistant Professor, Med. Sch., Case Western Reserve Univ., Cleveland/Ohio, USA
2001 - 2003 Senior Researcher, Dept. of Neurobiology, University of Düsseldorf
2002 Habilitation "Zoology"
since 6. 2003 Senior Researcher, Inst. of Clinical Physiology, Campus Benjamin Franklin, Charité, Berlin
2004 - 2012 Coordinating Officer for Research of the Inst. of Clinical Physiology
since 2012 Coordinating Officer for Teaching of the Inst. of Clinical Physiology
2006 Extension of habilitation field to "Zoology and Experimental Biomedicine"
since 2009 Member of the "Joint Committee for Bioinformatics", Freie Universität Berlin and Charité
Oct. 2015 Nomination as "Außerplanmäßige Professorin"

 

Neurobiology, Düsseldorf:
Intracellular Magnesium

  • First-time comparative measurements of intracellular [Mg2+] in different types of muscle in frog (Xenopus laevis) and crayfish (Procambarus clarki and Pacifastacus leniusculus) using ion-selective microelectrodes (Günzel & Galler, 1991) 
  • Regulation of intracellular [Mg2+] in 3 types of neurons (multifunctional Retzius neurons, mechano­sensoric P-(pressure-) neurons, non-classified Leydig-(50-) neurons) and in Neuropil glia cells of the leech (Hirudo medicinalis
  • Mg2+ regulation in neurons of the CA1 region of rat hippocampus