Publications: Michael Schumann
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PubMed list of Michael Schumann,
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2024
Horn V, Cancino CA, Steinheuer LM, Obermayer B, Fritz K, Nguyen AL, Juhran KS, Plattner C, Bösel D, Oldenburg L, Burns M, Schulz AR, Saliutina M, Mantzivi E, Lissner D, Conrad T, Mashreghi MF, Zundler S, Sonnenberg E, Schumann M, Haag LM, Beule D, Flatz L, TRR241 IBDome Consortium, Trjanoski Z, D'Haens G, Weidinger C, Mei HE, Siegmund B, Thurley K, Hegazy AN (2024) Multimodal profiling of peripheral blood identifies proliferating circulating effector CD4+ T cells as predictors for response to integrin α4β7-blocking therapy in inflammatory bowel disease.
Consortial collaborations
Erkert L, Gamez-Belmonte R, Kabisch M, Schödel L, Patankar JV, Gonzalez-Acera M, Mahapatro M, Bao LL, Plattner C, Kühl AA, Shen J, Serneels L, De Strooper B; TRR241 IBDome Consortium* (*with Schumann M); Neurath MF, Wirtz S, Becker C (2024) Alzheimer's disease-related presenilins are key to intestinal epithelial cell function and gut immune homoeostasis. Gut 73(10): 1618-1631. doi: 10.1136/gutjnl-2023-331622 (°IF 23.0)
Lehmann M, Weixler B, Elezkurtaj S, Loddenkemper C, TRR241 IBDome Consortium* (*with Schumann M), Kühl AA, Siegmund B (2024) Spatial Single Cell Profiling Using Imaging Mass Cytometry: Inflammatory Versus Penetrating Crohn's Disease.
Schulz-Kuhnt A, Rühle K, Javidmehr A, Döbrönti M, Biwank J, Knittel S, Neidlinger P, Leupold J, Liu LJ, Dedden M, Taudte RV, Gessner A, Fromm MF, Mielenz D, Kreiss L, Waldner MJ, Schürmann S, Friedrich O, Dietel B, López-Posadas R, Plattner C, TRR241 IBDome Consortium* (*with Schumann M), Zundler S, Becker C, Atreya R, Neurath MF, Atreya I (2024) ATP citrate lyase (ACLY)-dependent immunometabolism in mucosal T cells drives experimental colitis in vivo. Gut 73(4): 601-612. doi: 10.1136/gutjnl-2023-330543 (°IF 23.0)
2023
Waldow A*, Beier LS* (*shared first authorship), Arndt J, Schallenberg S, Vollbrecht C, Bischoff P, Farrera-Sal M, Loch FN, Bojarski C, Schumann M, Winkler L, Kamphues C, Ehlen L°, Piontek J° (°shared last authorship) (2023) cCPE fusion proteins as molecular probes to detect claudins and tight junction dysregulation in gastrointestinal cell lines, tissue explants and patient-derived organoids. Pharmaceutics 15(7): 1980 (23 pages). doi: 10.3390/pharmaceutics15071980 (IF.4.9)
Friebel J, Schinnerling K, Weigt K, Heldt C, Fromm A, Bojarski C, Siegmund B, Epple HJ, Kikhney J, Moter A, Schneider T, Schulzke JD, Moos V, Schumann M (2023) Uptake of Tropheryma whipplei by intestinal epithelia. Int. J. Mol. Sci. 24(7): 6197 (20 pages) doi: 10.3390/ijms24076197 (IF 4.9)
Wittner L, Wagener L, Wiese JJ, Stolzer I, Krug SM, Naschberger E, Jackstadt R, Beyaert R, Atreya R, Kühl AA, Sturm G, Gonzalez-Acera M, Patankar JV, Becker C, Siegmund B, Trajanoski Z, Winner B, Neurath MF, Schumann M, Günther C (2023) Proteolytic activity of the paracaspase MALT1 Is involved in epithelial restitution and mucosal healing. Int. J. Mol. Sci. 24(8): 7402 (21 pages), doi: 10.3390/ijms24087402 (IF 4.9)
2021
Delbue D, Lebenheim L, Cardoso-Silva D, Dony V, Krug SM, Richter JF, Manna S, Munoz M, Wolk K, Heldt C, Heimesaat M, Sabat R, Siegmund B, Schumann M (2021) Reprogramming intestinal epithelial cell polarity by interleukin-22. Front. Med. (Lausanne)doi: 10.3389/fmed.2021.656047 (IF 3.9)
Schulz E, Schumann M, Schneemann M, Dony V, Fromm A, Nagel O, Schulzke JD, Bücker R (2021) Escherichia coli alpha-hemolysin HlyA induces host cell polarity changes, epithelial barrier dysfunction and cell detachment in human colon carcinoma Caco-2 cell model via PTEN-dependent dysregulation of cell junctions. Toxins 13(8): 520 (22 pages). doi: 10.3390/toxins13080520. (IF 4.2)
2020
Jessen B, Rodriguez-Sillke Y, Sonnenberg E, Schumann M, Kruglov A, Freise I, Schmidt F, Maul J, Kühl AA, Glauben R, Lissner D, Siegmund B (2020) Level of tumor necrosis factor production by stimulated blood mononuclear cells can be used to predict response of patients with inflammatory bowel diseases to Infliximab. Clin. Gastroenterol. Hepatol. 19(4):721-731.e1, doi: 10.1016/j.cgh.2020.03.066 (IF 11.4)
2019
Delbue D, Cardoso-Silva D, Branchi F, Itzlinger A, Letizia M, Siegmund B, Schumann M (2019) Celiac disease monocytes induce a barrier defect in intestinal epithelial cells. Int. J. Mol. Sci.
20(22): 5597 (12 pages) (IF 4.6) [PubMed] [WebPage] [PDF]Langer V, Vivi E, Regensburger D, Winkler TH, Waldner MJ, Rath T, Schmid B, Skottke L, Lee S, Jeon NL, Wohlfahrt T, Kramer V, Tripal P, Schumann M, Kersting S, Handtrack C, Geppert CI, Suchowski K, Adams RH, Becker C, Ramming A, Naschberger E, Britzen-Laurent N, Stürzl M (2019) IFN-γ drives inflammatory bowel disease pathogenesis through VE-cadherin-directed vascular barrier disruption.
Tangermann P, Branchi F, Itzlinger A, Aschenbeck J, Schubert S, Maul J, Liceni T, Schröder A, Heller F, Spitz W, Möhler U, Graefe U, Radke M, Trenkel S, Schmitt M, Loddenkemper C, Preiß JC, Ullrich R, Daum S, Siegmund B, Bojarski C, Schumann M (2019) Low sensitivity of simtomax point of care test in detection of celiac disease in a prospective multicenter study. Clin. Gastroenterol. Hepatol. 17(9): 1780-1787 (IF 8.5) [PubMed] [WebPage] [PDF]
Richter JF, Hildner M, Schmauder R, Turner JR, Schumann M, Reiche J (2019) Occludin knockdown is not sufficient to induce transepithelial macromolecule passage. Tiss. Barriers 7(2): 1612661 (no IF yet) [PubMed] [WebPage] [Supplement]
Schmidt F, Dahlke K, Batra A, Keye J, Wu H, Friedrich M, Glauben R, Ring C, Loh G, Schaubeck M, Hackl H, Trajanoski Z, Schumann M, Kühl AA, Blaut M, Siegmund B (2019)Microbial colonization in adulthood shapes the intestinal macrophage compartment. J. Crohns Colitis 13(9): 1173-1185 (IF 8.7) [PubMed] [WebPage] [PDF]
Review
Cardoso-Silva D*, Delbue D* (*shared first authorship), Itzlinger A, Moerkens R, Withoff S, Branchi F, Schumann M (2019) Intestinal barrier function in gluten-related disorders. Nutrients 11(10): E2325 (19 pages) (IF 4.5) [PubMed] [WebPage] [PDF]
2018
Hinze C, Ruffert J, Walentin K, Himmerkus N, Nikpey E, Tenstad O, Wiig H, Mutig K, Yurtdas ZY, Klein JD, Sands JM, Branchi F, Schumann M, Bachmann S, Bleich M, Schmidt-Ott KM (2018)
GRHL2 is required for collecting duct epithelial barrier function and renal osmoregulation. J. Am. Soc. Nephrol. 29(3): 857-868 (IF 8.5) [PubMed] [WebPage] [PDF]Reiche J, Schumann M, Richter JF (2018) The sandwich assay: A method for subcellular visualization of paracellular macromolecule passage in epithelial sheets. Curr. Protoc. Cell Biol. 78(1): 20.10.1-20.10.13 (°no IF) [PubMed] [WebPage]
Ritter J, Zimmermann K, Jöhrens K, Mende S, Seegebarth A, Siegmund B, Hennig S, Todorova K, Rosenwald A, Daum S, Hummel M, Schumann M (2018) T-cell repertoires in refractory celiac disease. Gut 67(4): 644-653 (IF 17.9)
Turowski F, Hügle U, Dormann A, Bechtler M, Jakobs R, Gottschalk U, Nötzel E, Hartmann D, Lorenz A, Kolligs F, Veltzke-Schlieker W, Adler A, Becker O, Wiedenmann B, Bürgel N, Tröger H, Schumann M, Daum S, Siegmund B, Bojarski C (2018) Diagnostic and therapeutic single-operator cholangiopancreatoscopy with SpyGlassDS™: results of a multicenter retrospective cohort study.
Review
Itzlinger A, Branchi F, Elli L, Schumann M (2018) Gluten-free diet in celiac disease ̶ forever and for all? Nutrients 10(11): E1796 (IF 4.2) [PubMed] [WebPage] [PDF]
2017
Barmeyer C, Schumann M, Meyer T, Zielinski C, Zuberbier T, Siegmund B, Schulzke JD, Daum S, Ullrich R (2017) Long-term response to gluten-free diet as evidence for non-celiac wheat
sensitivity in one third of patients with diarrhea-dominant and mixed-type irritable bowel syndrome. Int. J. Colorectal Dis.
32(1): 29-39 (IF 2.4) [PubMed] [WebPage] [PDF]
Kroll LE, Schumann M, Müters S, Lampert T (2017)
Review
Schumann M, Siegmund B, Schulzke JD, Fromm M (2017) Celiac disease: role of the epithelial barrier. Cell. Mol. Gastroent. Hepatol. 3(2): 150-162 (°new journal, no IF yet) [PubMed] [WebPage] [PDF]
2016
Preiß JC, Barmeyer C, Bürgel N, Daum S, Epple HJ, Günther U, Maul J, Siegmund B, Schumann M, Tröger H, Stroux A, Adler A, Veltzke-Schlieker W, Jürgensen C, Wentrup R, Wiedenmann B, Binkau J, Hartmann D, Nötzel E, Domagk D, Wacke W, Wahnschaffe U, Bojarski C (2016) EndoClot polysaccharide hemostatic system in nonvariceal gastrointestinal bleeding: results of a prospective multicenter observational pilot study. J. Clin. Gastroenterol. 50(10): e95-e100
Richter JF, Schmauder R, Krug SM, Gebert A, Schumann M (2016) A novel method for imaging sites of paracellular passage of macromolecules in epithelial sheets. J. Contr. Release 229: 70-79 (IF 7.8) [PubMed] [WebPage] [PDF] [Supplement] [Movie S1] [Movie S2]
Review
Schumann M, Lebenheim L (2016) Neues zur Zöliakie [Celiac disease; article in German]. Dtsch. Med. Wochenschr. 141(20): 1474-1477 (IF 0.6) [PubMed] [WebPage] [PDF]
2015
Aue A*, Hinze C* (*shared first authorship), Ruffert J, Yurtdas Y, Werth M, Chen W, Walentin K, Rabien A, Kilic E, Schulzke JD, Schumann M, Schmidt-Ott KM (2015) A novel grainyhead-like 2/ovo-like 2 pathway regulates renal epithelial barrier function and lumen expansion. J. Am. Soc. Nephrol. 26(11): 2704-2715 (IF 8.5) [PubMed] [WebPage] [PDF] [Supplement]
Lissner D, Schumann M, Batra A, Kredel LI, Kühl AA, Erben U, May C, Schulzke JD, Siegmund B (2015) Monocyte and M1 macrophage-induced barrier defect contributes to chronic intestinal inflammation in IBD. Inflamm. Bowel Dis. 21(6): 1297-1305 (IF 4.4) [PubMed] [WebPage] [PDF]
Neumann K, Erben U, Kruse N, Wechsung K, Schumann M, Klugewitz K, Scheffold A, Kühl AA (2015) Chemokine transfer by liver sinusoidal endothelial cells contributes to the recruitment of CD4+ T cells into the murine liver. PLOS One 10(6): e0123867 (IF 3.1) [PubMed] [WebPage] [PDF]
Case reports
Kruis T, Jöhrens K, Moos V, Puls I, Siegmund B, Daum S, Schumann M (2015) A case series in patients with enteropathy and granulomatous diseases. BMC Gastroenterol. 15: 62 (7 printed pages) (IF 2.1) [PubMed] [WebPage] [PDF]
Weber M, Schumann M, Felber J, Mireskandari M, Schmidt C, Stallmach A (2015) Jejunal ulcerations - a diagnostic challenge in a patient with coeliac disease. Z. Gastroenterol. 53(11): 1261-1266 (IF 1.4) [PubMed] [WebPage] [PDF] (Text in German)
2014
Rinnenthal JL, Goebel HH, Preuße C, Lebenheim L, Schumann M, Moos V, Schneider T, Heppner FL, Stenzel W (2014) Inflammatory myopathy with abundant macrophages (IMAM): the immunology revisited. Neuromuscul. Disord. 24(2): 151-155 (IF 2.6) [PubMed] [WebPage] [PDF]
Schumann J, Stanko K, Woertge S, Appelt C, Schumann M, Kühl AA, Panov I, Schliesser U, Vogel S, Ahrlich S, Vaeth M, Berberich-Siebelt F, Waisman A, Sawitzki B (2014) The mitochondrial protein TCAIM regulates activation of T cells and thereby promotes tolerance induction of allogeneic transplants. Am. J. Transplant. 14(12): 2723-2735 (IF 5.7) [PubMed] [WebPage] [PDF] [Supplement]
Interdisciplinary discussion
Fischbach W, Al-Taie O, Dietrich C, Felber J, Schütte K, Schumann M (2014) Medical and surgical conditions for the treatment of malabsorption.Viszeralmedizin 30(3): 206-209 (IF -) [PubMed] [WebPage] [PDF]
2013
Schmidt C, Lautenschlaeger C, Collnot EM, Schumann M, Bojarski C, Schulzke JD, Lehr CM, Stallmach A (2013) Nano- and microscaled particles for drug targeting to inflamed intestinal mucosa: a first in vivo study in human patients. J. Control. Release 165(2): 139-145 (IF 7.6) [PubMed] [WebPage] [PDF]
2012
Schumann M, Günzel D, Buergel N, Richter JF, Troeger H, May C, Fromm A, Sorgenfrei D, Daum S, Bojarski C, Heyman M, Zeitz M, Fromm M, Schulzke JD (2012) Cell polarity-determining proteins Par-3 and PP-1 are involved in epithelial tight junction defects in celiac disease. Gut 61(2): 220-228 (IF 10.7) [PubMed] [WebPage] [PDF] [Supplements]
Schumann M, Kamel S, Pahlitzsch ML, Lebenheim L, May C, Krauss M, Hummel M, Daum S, Fromm M, Schulzke JD (2012) Defective tight junctions in refractory celiac disease. Ann. N.Y. Acad. Sci. 1258: 43-51
Schumann M*, Winter S* (*shared first authorship), Wichner K, May C, Kühl AA, Batra A, Siegmund B, Zeitz M, Schulzke JD, Lipp M, Höpken UE (2012) CCR7 deficiency causes diarrhea associated with altered ion transport in colonocytes in the absence of overt colitis. Mucosal Immunol. 5(4): 377-387
Batra A, Heimesaat MM, Bereswill S, Fischer A, Glauben R, Kunkel D, Scheffold A, Erben U, Kühl A, Loddenkemper C, Lehr HA, Schumann M, Schulzke JD, Zeitz M, Siegmund B (2012) Mesenteric fat – control site for bacterial translocation in colitis? Mucosal Immunol. 5(5): 580-591
Catassi C, Anderson RP, Hill ID, Koletzko S, Lionetti E, Mouane N, Schumann M, Yachha SK (2012) A world perspective on celiac disease. J. Pediatr. Gastroenterol. Nutr. 55(5): 494-499 (IF 2.2)
Hommel C, Knoedler M, Bojarski C, Schumann M, Epple HJ, Zeitz M, Daum S (2012) Diffuse gastric cancer with peritoneal carcinomatosis can mimic Crohn's disease. Case Rep. Gastroenterol. 6(3): 695-703 (IF -) [PubMed] [WebPage] [PDF]
Ménard S, Lebreton C, Schumann M, Matysiak-Budnik T, Dugave C, Bouhnik Y, Malamut G, Cellier C, Allez M, Crenn P, Schulzke JD, Cerf-Bensussan N,
Heyman M (2012) Paracellular versus transcellular intestinal permeability to gliadin peptides in active celiac disease. Am. J. Pathol. 180(2): 608-615
(IF 4.5)
[PubMed] [WebPage] [PDF] Review
Sapone A, Bai J, Ciacci C, Dolinsek J, Green PH, Hadjivassiliou M, Kaukinen K, Rostami K, Sander DS, Schumann M, Ullrich R, Villalta D, Volta U, Catassi C, Fasano A (2012) Spectrum of gluten-related disorders: consensus on new nomenclature and classification. BMC Med. 10: 13 (12 printed pages) (IF 6.7) [PubMed] [WebPage] [PDF]
2010
Günther U, Daum S, Heller F,
Schumann M, Loddenkemper C, Grünbaum M, Zeitz M, Bojarski C (2010) Diagnostic value of confocal endomicroscopy in celiac disease.
Endoscopy 42(3): 197-202
(IF 6.1) [PubMed] [WebPage]
[PDF] Case report
Schumann M, Kiewe P, Hartlieb S, Neumann M, Schilling A, Koch HC, Thiel E, Korfel A (2010) Diffuse leukoencephalopathy and brain edema:
Unusual presentations of CNS relapse of acute myeloid leukemia. J. Neuroimag.
20(2): 198-200
(IF 1.8) [PubMed] [WebPage]
[PDF] Review / book chapter
Bücker R, Schumann M, Amasheh S, Schulzke JD (2010) Claudins in intestinal function and disease. Curr. Top. Membr. 65: 195-227 (IF 0.7) [Directory] [WebPage] [PDF]
2009
Daum S, Ipczynski R, Schumann M, Wahnschaffe U, Zeitz M, Ullrich R (2009) High rates of complications and substantial mortality in both types of
refractory sprue.
Eur. J. Gastroenterol. Hepatol. 21(1): 66-70 (IF 1.7) [PubMed]
[WebPage]
[PDF] Review
Schulzke JD*, Ploeger S* (*shared first authorship), Amasheh M, Fromm A, Zeissig S, Troeger H, Richter JF, Bojarski C, Schumann M, Fromm M (2009) Epithelial tight junctions in intestinal inflammation. Ann. N.Y. Acad. Sci. 1165: 294-300 (IF 2.7) [PubMed] [WebPage] [PDF]
2008
Schumann M, Nakagawa T, Mantey SA, Howell B, Jensen RT (2008) Function of non-visual arrestins in signaling and endocytosis of the gastrin-releasing peptide receptor (GRP receptor). Biochem. Pharmacol. 75(5): 1170-1185 (IF 4.8) [PubMed] [WebPage] [PDF]
Schumann M, Richter JF, Wedell I, Moos V, Zimmermann-Kordmann M, Schneider T, Daum S, Zeitz M, Fromm M, Schulzke JD (2008) Mechanisms of
epithelial translocation of the
a2-gliadin-33mer in celiac sprue.
Schrage A, Wechsung K, Neumann K,
Schumann M, Schulzke JD, Engelhardt B, Zeitz M, Hamann A, Klugewitz K (2008) Enhanced T cell transmigration across the murine liver sinusoidal endothelium is mediated by transcytosis and
surface presentation of chemokines. Hepatology 48(4): 1262-1272
(IF 11.4) [PubMed] [WebPage]
[PDF] Case report
Schumann M, Preiss JC, Loddenkemper C, Günther U, Somasundaram R, Siegmund B, Zeitz M (2008) [Nodular regenerative hyperplasia as a side effect of azathioprine in a patient with Crohn's disease] Dtsch. Med. Wochenschr. 133(38): 1897-1900 (IF 0.6) [PubMed] [WebPage] [PDF]
2005 - 2006
Mantey SA, Gonzalez N, Schumann M, Pradhan TK, Shen L, Coy DH, Jensen RT (2006) Identification of bombesin receptor subtype-specific ligands: effect of N-methyl scanning, truncation, substitution, and evaluation of putative reported selective ligands. J. Pharmacol. Exp. Ther. 319(2): 980-989 [PubMed] [WebPage] [PDF]
Nakagawa T, Hocart SJ, Schumann M, Tapia JA, Mantey SA, Coy DH, Tokita K, Katsuno T, Jensen RT (2005) Identification of key amino acids in the gastrin-releasing peptide receptor (GRPR) responsible for high affinity binding of gastrin-releasing peptide (GRP). Biochem. Pharmacol. 69(4): 579-593 [PubMed] [WebPage] [PDF]
2003 - 2004
Schumann M, Nakagawa T, Mantey SA, Tokita K, Venzon DJ, Hocart SJ, Benya RV, Jensen RT (2003) Importance of amino acids of the central portion of the second intracellular loop of the gastrin-releasing peptide receptor for phospholipase C activation, internalization, and chronic down-regulation. J. Pharmacol. Exp. Ther. 307(2): 597-607 (IF 4.3) [PubMed] [Full paper WebPage] [PDF]
Moody TW, Mantey SA, Pradhan TK,
Schumann M, Nakagawa T, Martinez A, Fuselier J, Coy DH, Jensen RT (2004) Development of high affinity camptothecin-bombesin conjugates that have targeted cytotoxicity for bombesin
receptor-containing tumor cells.
J. Biol. Chem. 279(22): 23580-23589 [PubMed] [WebPage]
[PDF] Review
Gibril F, Schumann M, Pace A, Jensen RT (2004) Multiple endocrine neoplasia type 1 and Zollinger-Ellison syndrome: a prospective study of 107 cases and comparison with 1009 cases from the literature. Medicine (Baltimore) 83(1): 43-83. [PubMed] [WebPage] [PDF] Erratum: 83(3): 175
