Freitag, 25. Juni 1999, 14¹⁵ bis 18 Uhr
UKBF, I. Stock, Großer Konferenzraum (gegenüber Dekanat)

14:15  Prof. Dr. Michael Wiederholt: Eröffnung
14:20  Prof. Dr. Martin Paul, Dekan des Fachbereichs Humanmedizin: Begrüßung
14:30  Das Institut für Klinische Physiologie stellt sich vor - Kurzpräsentation neuer Forschung: Priv.-Doz. Dr. Olaf Strauß, Dr. Hagen Thieme, Dr. Alfred Gitter, Dr. Ingo Grotjohann / Dr. Salah Amasheh
15:00  Prof. Dr. Dr. Rolf Winau: Geschichte der Nephrologie und Urologie in Berlin
15:20  Prof. Dr. Natale de Santo: The History of Common Salt
15:40  Pause
16:50  Prof. Dr. Dr.h.c. Roland Felix: Geschichte der Kontrastmittel in Berlin
17:10  Prof. Dr. Michael Hubenstorf: Exodus von Wissenschaften aus Berlin vor und nach 1933
17:40  Prof. Dr. Peter Gaehtgens, Präsident der Freien Universität Berlin: Schlußbemerkungen

March 26 - 27, 1999
Hotel Four Seasons, Berlin

Session I Expression of transporters and regulation of ion transport
chair: H. Cooke, M. Donowitz, E.O. Riecken
  9:20 U. Seidler (Tübingen) Na⁺HCO₃^– cotransport and NBC1 expression in the upper gastrointestinal tract
  9:45 V.M. Rajendran (New Haven) Molecular physiology of colonic bicarbonate transport
10:10 M. Donowitz (Baltimore) Na⁺/H⁺ exchanger along the gastrointestinal tract
10:35 G. Rechkemmer (Karlsruhe) Cellular localization and segmental differences in K⁺ transport regulation
11:20 H.J. Binder (New Haven) Role of a novel Cl^–-dependent Na⁺/H⁺ exchange in crypt function
11:45 E.M. Wright (Los Angeles) SGLT1 and water transport
12:10 K. Barrett (San Diego) Intracellular regulation of Cl^– secretion: new pathways and messengers
12:35 H. Cooke (Columbus) Neurotransmitters in neuronal reflexes regulating secretion

Poster Introduction
chair: H. Cooke, M. Donowitz, E.O. Riecken
13:00 H. Rossmann, U. Seidler (Tübingen) AE2 subtypes in the gastrointestinal tract
13:03 S. Amasheh, H.J. Epple (Berlin) Expression of ENaC in the distal colon
13:06 K. Huber, G. Breves (Hannover) Epithelial phosphate transporters in small ruminants
13:09 T. Frieling (Düsseldorf) Inflammatory mediators influencing submucosal secretory reflexes
13:12 J. Oprins (Amsterdam) TNFa effect on PKC-mediated secretion after muscarinic activation
13:15 D. Wermelskirchen, K. Schneider (Neuss) Investigation of motility and secretion in perfused guinea pig colon
13:18 F. Stümpel (Göttingen) Hormonal and neuronal control of small intestinal glucose-absorption
13:21 H. Bode, R. Ullrich (Berlin) Effect of HIV protease inhibitors on barrier function
13:24 B. Kräling, W. Franke (Heidelberg) Induction of endothelial barrier function in vitro: a lesson for studies of epithelia

Session II Structure and regulation of the intestinal barrier
chair: C.J. Bentzel, W. Caspary, W. Franke
15:30 S. Tsukita (Kyoto) Claudin multigene family encoding 4-transmembrane domain protein components of tight junction strands
15:55 R. Tauber, R. Gessner (Berlin) Intestinal cell adhesion molecules: liver-intestine-cadherin
16:20 W. Franke (Heidelberg) Junctional proteins: symplekin
17:00 C. Parkos (Atlanta) Tight junction changes during inflammation
17:25 P. Möller (Ulm) Barrier function in ulcerative colitis: influence of apoptosis
17:50 T. Kucharzik, R. Stoll (Münster) Role of M-cells in intestinal barrier function

Saturday, March 27, 1999
Session III Models for studying disturbed transport and barrier properties
chair: K. Barrett, M. Fromm, M. Gregor
  9:00 H. Daniel (Giessen) Nutrient transporter function in heterologous expression systems
  9:25 A.H. Gitter, M. Fromm (Berlin) Conductance scanning: apical membrane, tight junction, and apoptosis
  9:50 B. Wiedenmann, I. Horak (Berlin) Colitis in IL2-knock out mice
10:15 A. Fasano (Baltimore) Zonula occludens toxin effects on epithelial barrier function
11:00 J. Stein, W. Caspary (Frankfurt) GTP binding proteins in tight junction regulation
11:25 J.M. Mullin (Wynnewood) Tight junction regulation by PKC and phorbol esters: implication for epithelial cancers
11:50 J. Groot (Amsterdam) Stress induced decrease of the intestinal barrier function
12:15 M. Perdue (Ontario) Immunologically mediated transport of ions and macromolecules

Poster Introduction
chair: K. Barrett, M. Fromm, M. Gregor
12:40 G. Schultheiß, M. Diener (Giessen) Carbachol induced Ca²⁺ entry into rat colonic epithelium
12:43 S. Bühner, H. Lochs (Berlin) LPS effects on secretion in human large intestine
12:46 P. Bijlsma (Amsterdam) Tight junctions in microvillus inclusion disease
12:49 C. Bojarski, J.D. Schulzke (Berlin) Apoptosis and barrier function in HT-29/B6 cells
12:52 L. Karcewski (Amsterdam) Mechanisms of p53-independent apoptosis in the Caco-2 cell line
12:55 J. Stein, V. Milovic (Frankfurt) Growth factors and epithelial remodeling in Caco-2 cells
12:58 I. Grotjohann (Berlin) Effect of TNFa on rat rectum in vitro
13:01 A.J. Kroesen, H.J. Buhr (Berlin) Colectomy and ileal pouch: transport and barrier in pouchitis

Session IV Diarrheal mechanisms in gastrointestinal diseases
chair: H. Binder, G.I. Sandle, J.D. Schulzke
15:00 M. Stockmann, J.D. Schulzke (Berlin) Mechanisms of epithelial barrier impairment in HIV-infection
15:25 M. Heyman, J.F. Desjeux (Paris) Cytokine induced regulation of the epithelial barrier in disease
15:50 H. Schmitz, J.D. Schulzke (Berlin) Transport and barrier function in ulcerative colitis
16:15 G.I. Sandle (Leeds) Pathology of sodium transport in ulcerative colitis
17:00 J.B. Meddings (Calgary) Epithelial transport and barrier function: pathomechanisms in gastrointestinal disorders
17:25 E. Beubler (Graz) Mechanisms of cholera toxin induced diarrhea
17:50 C. Pothoulakis (Boston) Clostridium difficile toxin effects on transport and barrier
18:15 M.C. Rao (Chicago) Ion transport during growth and differentiation

Samstag, 28. März 1998, 9³⁰ bis 15³⁰ Uhr
UKBF, Hörsaal West

  9:30 -   9:45  Prof. Dr. Michael Foerster (Berlin) Einführung in das Thema
  9:45 - 10:00  Prof. Dr. Michael Wiederholt (Berlin) Mythen und Fakten: Der intraokulare Druck
10:00 - 10:30  Prof. Dr. Dr. Eugen Gramer (Würzburg) Bedeutung der Familien-Anamnese beim Glaukom
10:30 - 11:00  Prof. Dr. Elke Lütjen-Drecoll (Erlangen) Morphologische Veränderungen der Kammerwasserabflußwege beim Glaukom
11:30 - 12:00  Prof. Dr. Dr. Bernhard Lachenmayr (München) Perimetrie
12:00 - 12:30  Prof. Dr. Matthias Korth (Erlangen) Sinnesphysiologische Untersuchungsmethoden in der Frühdiagnose der Glaukome
13:30 - 14:00  Prof. Dr. Fritz Dannheim (Rosengarten) Leitlinien zur Glaukombetreuung
14:00 - 14:30  Prof. Dr. Dr. Christian Hartmann (Berlin) Operative Verfahren
14:30 - 15:00  Prof. Dr. Günter Krieglstein (Köln) Pharmakotherapie der Glaukome - Anspruch und Wirklichkeit
15:00 - 15:30  Prof. Dr. Michael Wiederholt (Berlin) Perspektiven: Beeinflussung der Kontraktilität des Trabekelwerks