Date           Friday April 25, 2008 – Sunday April 27, 2008

Location    Harnack House of the Max-Planck-Gesellschaft, Ihnestrasse 16-20, 14195 Berlin-Dahlem

Friday, April 25

Start  

15:00

Michael Fromm

Opening

15:10

Martin Zeitz

Welcome address by the Director of the Charité Center 10

15:15

James Anderson

Life and work of Shoichiro Tsukita

15:30

Session A

Molecular structure of the tight junction

Chairs: J. Anderson, R. Tauber

15:30

0:25

Charles Parkos (Atlanta, GA)

Mechanisms of outside-in signaling at the tight junction

15:55

0:25

Ingolf Blasig (Berlin, Germany)

Self-association of tight junction proteins

16:20

0:25

Walter Hunziker (Singapore, Singapore)

ZO proteins: from cells to fish to mice and back

16:45

0:25

Gerd Krause (Berlin, Germany)

Structure and function of extracellular claudin domains

17:10

0:30

Coffee break @ Bismarck Hall & Winter Garden

17:40

0:25

Sachiko Tsukita (Kyoto, Japan)

Claudin-15-deficient mice

18:05

0:25

Alan Yu (Los Angeles, CA)

Molecular basis for cation selectivity in claudin-2-based pores

18:30

0:25

Mikio Furuse (Kyoto, Japan)

Internalization of claudins from tight junctions

18:55

0:25

Radhakrishna Rao (Memphis, TN)

Role of occludin phosphorylation in regulation of TJ integrity

19:20

0:13

Otmar Huber (Berlin, Germany)

Molecular interaction between occludin and tricellulin

19:33

19:45

Get together @ Bismarck Hall & Winter Garden

Saturday, April 26

8:30

Session B

Regulation of the tight junction and barrier function

Chairs: G. Krause, L. Mayer, E. Schneeberger

8:30

0:25

Maria Balda (London, UK)

Tight junction proteins and cell differentiation

8:55

0:25

Michael Fromm (Berlin, Germany)

High resolution analysis of barrier function

9:20

0:25

Christina van Itallie (Chapel Hill, NC)

Claudins determine charge and size selectivity of tight junction pores

9:45

0:25

Sandra Citi (Geneva, Switzerland)

Regulation of gene expression and GTPase activity by cingulin and paracingulin

10:10

0:30

Coffee break

10:40

0:25

Jim Mullin (Wynnewood, PA)

Modulation of tight junction permeability by methionine restriction

11:05

0:25

Alan Fanning (Chapel Hill, NC)

ZO-1 regulates the "when" and the "where" of tight junction strand assembly

11:30

0:25

Lorenza Gonzalez-Mariscal (Mex. City, Mexico)

The tight junction protein ZO-2 blocks cell cycle progression in epithelial cells by inhibiting cyclin D1 expression

11:55

0:25

Dominik Mueller (Berlin, Germany)

Mouse models to mimic human claudin-associated disorders

12:20

1:00

Lunch @ Bismarck Hall & Winter Garden

13:20

0:25

Yan-hua Chen (Greenville, NC)

Acute renal tubular necrosis in claudin-7 deficient mice

13:45

0:25

Alastair Watson (Liverpool, UK)

Maintenance of barrier function during cell shedding

14:10

0:25

Dietmar Vestweber (Muenster, Germany)

Regulation of endothelial cell contacts in leukocyte extravasation

14:35

0:13

Susanne Angelow (Los Angeles, CA)

Cysteine mutagenesis to study the structure of claudin-2 paracellular pores

14:48

0:13

Markus Bleich (Kiel, Germany)

Impact of claudin16 defect on salt and acid base balance

15:01

0:30

Coffee break

15:31

0:13

Michel Boivin (Albuquerque, NM)

Tight junction regulation by cytokines

15:44

0:13

Dorothee Günzel (Berlin, Germany)

Claudin function in distal nephron cells

15:57

0:13

Carien Niessen (Köln, Germany)

Tight junction formation in stratifying epithelia

16:10

 16:20

Session C

Immune system, microbes, and gastrointestinal barrier

Chairs: J. Turner, M. Zeitz

16:20

0:25

Hans Christian Reinecker (Boston, MA)

Tight junctional signal transduction in epithelial defense activation

16:45

0:25

Gail Hecht (Chicago, IL)

Tight junction and E. coli toxins

17:10

0:30

Coffee break

17:40

0:25

Kim Barrett (San Diego, CA)

Modulation of intestinal barrier properties by probiotics – role in reversing colitis

18:05

0:13

Matthias Bruewer (Muenster, Germany)

Probiotic mixture VSL#3 protects the epithelial barrier and ameliorates inflammation in a murine model of colitis

18:18

0:13

Matthew Ciorba (St. Louis, MO)

Lactobacillus rhamnosus GG prevents radiation-induced small intestinal injury in a MyD88-independent, but COX2-dependent manner

18:31

0:25

Alessio Fasano (Baltimore, MD)

Tight junctions and autoimmune diseases: the celiac disease paradigm

18:56

0:13

Johan Söderholm (Linkoeping, Sweden)

Nerve–mast cell interaction in the regulation of barrier function in the human colon

19:09

19:30

Conference Dinner @ Liebig Vault

21:00

"The Tight Junctions" @ Bismarck Hall & Winter Garden

Sunday, April 27

8:30

Session D

Transport and epithelial barrier

Chairs: K. Barrett, H. Binder

8:30

0:25

Salah Amasheh (Berlin, Germany)

Transcellular transport and paracellular barrier

8:55

0:25

Asma Nusrat (Atlanta, GA)

Apical junctional complex: a dynamic kiss that controls epithelial differentiation and barrier function

9:20

0:25

Hans-Joachim Galla (Muenster, Germany)

Regulation of the blood-brain barrier by the plasticity of the extracellular matrix

9:45

0:25

Mark Donowitz (Baltimore, MD)

NHE3 regulation: a story of complexes and cytoskeleton

10:10

0:30

Coffee break

10:40

0:25

Ursula Seidler (Hannover, Germany)

The role of the NHERF family of PDZ-scaffolding proteins in the regulation of intestinal salt and water transport

11:05

0:13

Hans-Georg Lamprecht (Tübingen, Germany)

Regulation of the intestinal anion exchanger DRA (SLC26A3)

11:18

0:13

Maren Amasheh (Berlin, Germany)

Barrier effects of nutritional factors

11:31

0:13

Martine Heyman (Paris, France)

Pathways of gliadin transport in celiac disease

11:44

0:13

Mirajul Kazi (Baltimore, MD)

Dual roles of Zn in intestinal ion transport: stimulation of Na⁺ absorption and inhibition of Cl^– secretion in Caco-2 cells

11:57

12:00

1:00

Lunch @ Bismarck Hall & Winter Garden

13:00

Session E

Inflammation and gastrointestinal function

Chairs: G. Hecht, G. Sandle

13:00

0:25

Henry Binder (New Haven, CT)

Mechanism of diarrhea in inflammatory bowel disease

13:25

0:25

Joerg-Dieter Schulzke (Berlin, Germany)

Tight junctions in intestinal inflammation

13:50

0:13

Theresa Pizarro (Charlottesville, VA)

Mechanisms of TJ dysfunction in the SAMP1/YitFc model of Crohn's disease-like ileitis

14:03

0:25

Silvio Danese (Milano, Italy)

The role of JAM-A in inflammatory bowel disease

14:28

0:25

Jerrold Turner (Chicago, IL)

IBD – not just another break in the wall

14:53

0:13

Maria Claire Arrieta (Edmonton, Canada)

Reducing small intestinal permeability attenuates colitis in the IL-10 gene-deficient mouse

15:06

0:30

Coffee break

15:40

0:25

Lloyd Mayer (New York, NY)

Lymphoepithelial interactions: regulation of epithelial cell differentiation

16:05

0:25

Derek McKay (Hamilton, Ontario)

Dissecting epithelial signal transduction events that control epithelial permeability

16:30

0:25

Jon Meddings (Edmonton, Canada)

Small bowel permeability in the IL-10^-/- model of colitis

16:55

0:25

Daniel Teitelbaum (Ann Arbor, MI)

Enteral versus parenteral nutrition: effect on barrier function

17:20

0:10

Jörg Schulzke

Concluding remarks

17:30

End of conference

18:00

Departure for Speaker's Dinner

19:00  Speaker's Dinner @ Reichstag / Deutscher Bundestag (70 pers.)