DFG Research Unit FOR 721 @DFG

Molecular Structure and Function of the Tight Junction

Coordinator 
Prof. Michael Fromm
Inst. of Clinical Physiology CBF, Charité,
Freie Universität and Humboldt-Universität, Berlin
 , phone +49 30 8445-2787
  Deputy Coordinator
Prof. Joerg-Dieter Schulzke
Dept. of Gastroenterology CBF, Charité,
Freie Universität and Humboldt-Universität, Berlin
, phone +49 30 8445-2666
 
Projects of the first funding period, 11.2006 - 12.2009

TP 1

Salah Amasheh, Michael Fromm
Institute of Clinical Physiology CBF, Charite
"Characterization of tight junction proteins as barrier- or channel-formers"

TP 2

Joerg-Dieter Schulzke, Joachim Mankertz, Anton J. Kroesen#
Dept. of Gastroenterology CBF, Charite, and #Dept. of Surgery CBF, Charite
"Tight junction proteins in inflammatory bowel diseases"

TP 3

Otmar Huber, Rudolf Tauber
Central Institute of Laboratory Medicine and Pathobiochemistry CBF, Charite
"Posttranslational modulation of the structure and function of the tight junction"

TP 4  

Dominik Mueller, Thomas Willnow§
Details Pediatric Nephrology CVK, Charite, and §Max Delbrueck Center (MDC) / Inst. of Clinical Pharmacology CBF, Charite
"Tight junction proteins: role in ion homeostasis and blood pressure regulation"

TP 6

Gerd Krause, Peter Schmieder&
Leibniz Institute of Molecular Pharmacology (FMP), Structural Bioinformatics & Protein Design, and &FMP, Solution State NMR Spectroscopy
"Molecular and structural patterns of paracellular pores by subtype-dependent claudin-claudin interactions in tight junctions"

TP Z

Michael Fromm, Joerg-Dieter Schulzke*
Institute of Clinical Physiology CBF, Charite and *Dept. of Gastroenterology CBF, Charite
"Freeze fracture electron microscopy; general duties"
     
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