DFG Research Training Group "TJ-Train" (GRK 2318)
Tight junctions and their proteins
Molecular features and actions in health and disease

                
 Publications of the doctoral students

Back            Updated 23.07.2021

 
Project A1
  • Mannweiler R, Bergmann S, Vidal-Y-Sy S, Brandner JM, Günzel D (2021) Direct assessment of individual skin barrier components by electrical impedance spectroscopy. Allergy 76(10): 3094-3106 (13 pages). doi: 10.1111/all.14851, Supplement PDF (°IF 13.1)

  • Alzahrani AS, Hussein M, Alswailem M, Mouna A, Albalawi L, Moria Y, Jabbar MA, Shi Y, Günzel D*, Dasouki M* (*equally contributing) (2021) A novel claudin-10 mutation with a unique mechanism in two unrelated families with HELIX syndrome. Kidney Int. 100(2): 415-429, doi: 10.1016/j.kint.2021.02.023, Supplement (°IF 10.6)

Project A2

  • Beier LS, Rossa J, Woodhouse S, Bergmann S, Kramer HB, Protze J, Eichner M, Piontek A, Vidal-y-Sy S, Brandner JM, Krause G, Zitzmann N, Piontek J (2019) Use of modified Clostridium perfringens enterotoxin fragments for claudin targeting in liver and skin cells. Int. J. Mol. Sci. 20(19): 4774 (20 pages) [PubMed] [WebPage] [PDF] (IF 4.6) [Supplement PDF]

  • Piontek A, Eichner M, Zwanziger D, Beier LS, Protze J, Walter W, Theurer S, Schmid KW, Führer-Sakel D, Piontek J*, Krause G* (*shared last authorship) (2020) Targeting claudin-overexpressing thyroid and lung cancer by modified Clostridium perfringens enterotoxin. Mol. Oncol. 14(2): 261-276 [PubMed] [WebPage] [PDF] (IF 6.6)

Project A3

  • Ayala-Torres C, Krug SM, Rosenthal R*, Fromm M* (*shared last authorship) (2021) Angulin-1 (LSR) affects paracellular water transport, however only in tight epithelial cells. Int. J. Mol. Sci. 22: 7827 (25 pages). doi: 10.3390/ijms22157827 (°IF 5.9)

  • Ayala-Torres C, Krug SM, Schulzke JD, Rosenthal R*, Fromm M* (*shared last authorship) (2019) Tricellulin effect on paracellular water transport. Int. J. Mol. Sci. 20 (22): 5700 (15 pages) [PubMed] [WebPage] [PDF] (IF 4.6)

  • Rosenthal R, Günzel D, Piontek J, Krug SM, Ayala-Torres C, Hempel C, Theune D, Fromm M (2020) Claudin-15 forms a water channel through the tight junction with distinct function compared to claudin-2. Acta Physiol. 228(1): e13334 (15 pages) [PubMed] [WebPage] [PDF]  (IF 6.3)


Project A4

  • Mecklenburg N*, Kowalczyk I*, Witte F* (*shared first authorship), Goerne J, Laier A, Mamo TM, Gonschior H, Lehmann M, Richter M, Sporbert A, Purfuerst B, Hübner N, Hammes A (2021) Identification of novel disease relevant modulators of the SHH pathway in the developing brain. Development

  • Gonschior H, Haucke V, Lehmann M (2020) Super-resolution imaging of tight and adherens junctions: Challenges and open questions. Int. J. Mol. Sci. 21(3): 744 (15 pages) [PubMed] [WebPage] [PDF]  (Review) (IF 5.9)

Project B1

  • Mecklenburg N*, Kowalczyk I*, Witte F* (*shared first authorship), Goerne J, Laier A, Mamo TM, Gonschior H, Lehmann M, Richter M, Sporbert A, Purfuerst B, Hübner N, Hammes A (2021) Identification of novel disease relevant modulators of the SHH pathway in the developing brain. Development

  • Kowalczyk I, Lee C, Schuster E, Hoeren J, Trivigno V, Riedel L, Görne J, Wallingford JB, Hammes A, Feistel K (2021) Neural tube closure requires the endocytic receptor Lrp2 and its functional interaction with intracellular scaffolds. Development

Project B2

  • Cardoso-Silva D*, Delbue D* (*shared first authorship), Itzlinger A, Moerkens R, Withoff S, Branchi F, Schumann M (2019) Intestinal barrier function in gluten-related disorders. Nutrients 11(10): 2325 (19 pages) [PubMed] [WebPage] [PDF (Review) (IF 4.5) #

  • Delbue D, Lebenheim L, Cardoso-Silva D, Dony V, Krug SM, Richter JF, Manna S, Muñoz M, Wolk K, Heldt C, Heimesaat MM, Sabat R, Siegmund B, Schumann M (2021) Reprogramming intestinal epithelial cell polarity by interleukin-22. Front. Med. (Lausanne) 8: 656047. doi: 10.3389/fmed.2021.656047 (°IF 5.1) #

  • Delbue D, Cardoso-Silva D, Branchi F, Itzlinger A, Letizia M, Siegmund B, Schumann M (2019) Celiac disease monocytes induce a barrier defect in intestinal epithelial cells. Int. J. Mol. Sci. 20(22): 5597 (12 pages) [PubMed] [WebPage] [PDF] (IF 4.6) #

Project B3

  • Franken GAC*, Seker M* (*shared first authorship), Bos C, Siemons LAH, van der Eerden BCJ, Christ A, Hoenderop JGJ, Bindels RJM, Müller D, Breiderhoff T, de Baaij JHF (2021) Cyclin M2 (CNNM2) knockout mice show mild hypomagnesaemia and developmental defects. Sci. Rep. 11(1): 8217. doi: 10.1038/s41598-021-87548-6. (°IF 4.4)

  • Seker M, Fernandez-Rodriguez C, Martinez-Cruz LA, Müller D (2019) Mouse models of human claudin-associated disorders: benefits and limitations. Int. J. Mol. Sci. 20(21): 5504 (19 pages) [PubMed] [WebPage] [PDF]  (Review) (IF 4.6)

Project B4

  • Leiz J*, Hinze C* (*shared first authorship), Boltengagen A, Braeuning C, Kocks C, Rajewsky N, Schmidt-Ott KM (2021) Nuclei isolation from adult mouse kidney for single-nucleus RNA-sequencing. J. Vis. Exp. (20.07.2021 accepted for publication) (°IF 1.4)

  • Leiz J, Schmidt-Ott K (2020) Claudins in the renal collecting duct. Int. J. Mol. Sci. 21(1): 221 (11 pages) (Review) [PubMed] [WebPage] [PDF] (IF 5.9)

Project C1

  • Nattramilarasu PK, Lobo de Sá FD, Schulzke JD, Bücker R (2021) Immune-mediated aggravation of the Campylobacter concisus-induced epithelial barrier dysfunction. Int. J. Mol. Sci. 22(4): 2043 (23 pages). doi: 10.3390/ijms22042043, Supplement PDF (°IF 5.9)

  • Nattramilarasu PK, Bücker R, Lobo de Sá FD, Fromm A, Nagel O, Lee IM, Butkevych E, Mousavi S, Genger C, Kløve S, Heimesaat MM, Bereswill S, Schweiger MR, Nielsen HL, Troeger H, Schulzke JD (2020) Campylobacter concisus impairs sodium absorption in colonic epithelium via ENaC dysfunction and claudin-8 disruption. Int. J. Mol. Sci. 21(2): e373 (23 pages) [PubMed] [WebPage] [PDF] [Supplements] (IF 5.9)

  • Butkevych E, Lobo De Sá FD, Nattramilarasu PK, Bücker R (2020) Contribution of epithelial apoptosis and subepithelial immune responses in Campylobacter jejuni-induced barrier disruption Front. Microbiol. 11: 344 (14 pages) [PubMed] [WebPage] [PDF] (IF 5.6)

  • Lobo de Sá FD, Heimesaat MM, Bereswill S, Nattramilarasu PK, Schulzke JD, Bücker R (2021) Resveratrol prevents Campylobacter jejuni-Induced leaky gut by restoring occludin and claudin-5 in the paracellular leak pathway. Front. Pharmacol. 12: 640572. doi: 10.3389/fphar.2021.640572 (°IF 5.8)

  • Lobo de Sá FD, Butkevych E, Nattramilarasu PK, Fromm A, Mousavi S, Moos V, Golz JC, Stingl K, Kittler S, Seinige D, Kehrenberg C, Heimesaat MM, Bereswill S, Schulzke JD*, Bücker R (*corresponding) (2019) Curcumin mitigates immune-induced epithelial barrier dysfunction by Campylobacter jejuni. Int. J. Mol. Sci. 20(19): 4830 (19 pages) [Pubmed] [WebPage] [PDF] (IF 4.6)

  • Schulz E, Schumann M, Schneemann M, Dony V, Fromm A, Nagel O, Schulzke JD, Bücker R (2021) Escherichia coli alpha-hemolysin HlyA induces host cell polarity changes, epithelial barrier dysfunction and cell detachment in human colon carcinoma  Caco-2 cell model via PTEN-dependent dysregulation of cell junctions. Toxins 13(8): 520 (22 pages). doi: 10.3390/toxins13080520. (°IF 4.5) #

Project C2

  • Hu JCE, Weiß F, Bojarski C, Branchi F, Schulzke JD, Fromm M, Krug SM (2021) Expression of tricellular tight junction proteins and the paracellular macromolecule barrier are recovered in remission of ulcerative colitis. BMC Gastroenterology 21(1): 141, doi: 10.1186/s12876-021-01723-7 (°IF 3.1) 

  • Hu JCE, Bojarski C, Branchi F, Fromm M, Krug SM (2020) Leptin downregulates angulin-1 in active Crohn's disease via STAT3. Int. J. Mol. Sci. 21(21): 7824 (17 pages) [PubMed] [WebPage] [PDF] [Supplement] (IF 5.9)

Project C3

  • Delbue D, Lebenheim L, Cardoso-Silva D, Dony V, Krug SM, Richter JF, Manna S, Muñoz M, Wolk K, Heldt C, Heimesaat MM, Sabat R, Siegmund B, Schumann M (2021) Reprogramming intestinal epithelial cell polarity by interleukin-22. Front. Med. (Lausanne) 8: 656047. doi: 10.3389/fmed.2021.656047 (°IF 5.1) #

  • Delbue D, Cardoso-Silva D, Branchi F, Itzlinger A, Letizia M, Siegmund B, Schumann M (2019) Celiac disease monocytes induce a barrier defect in intestinal epithelial cells. Int. J. Mol. Sci. 20(22): 5597 (12 pages) [PubMed] [WebPage] [PDF] (IF 4.6) #

  • Cardoso-Silva D*, Delbue D* (*shared first authorship), Itzlinger A, Moerkens R, Withoff S, Branchi F, Schumann M (2019) Intestinal barrier function in gluten-related disorders. Nutrients 11(10): 2325 (19 pages) [PubMed] [WebPage] [PDF] (Review) (IF 4.5) #

  • Schulz E, Schumann M, Schneemann M, Dony V, Fromm A, Nagel O, Schulzke JD, Bücker R (2021) Escherichia coli alpha-hemolysin HlyA induces host cell polarity changes, epithelial barrier dysfunction and cell detachment in human colon carcinoma Caco-2 cell model via PTEN-dependent dysregulation of cell junctions. Toxins 13(8): 520 (22 pages). doi: 10.3390/toxins13080520. (°IF 4.5) #

Project C4

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 IF = Journal Impact factor of the respective publication year
°IF
= Journal Impact factor for 2020, ad interim applied for 2021 papers

"accepted for publication": editotial acceptance e-mail at hand
#: Paper is authored by doctoral students of different projects, thus appearing more than once in the list

 
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