ClinPhysio     GRK 2318 Charité site

DFG Research Training Group "TJ-Train", GRK 2318

Tight junctions and their proteins:
molecular features and actions in health and disease

Coordinator 
Prof. Jörg-Dieter Schulzke
Clinical Physiology / Nutritional Medicine
Charité - Universitätsmedizin Berlin
 , phone +49 30 450-514531
  Deputy Coordinator
Prof. Dorothee Günzel
Clinical Physiology / Nutritional Medicine
Charité - Universitätsmedizin Berlin
 , phone +49 30 450-514525
Scientific Coordinator
Priv.-Doz. Dr. Rita Rosenthal
 , phone +49 30 450-514527

"TJ-Train" (GRK 2318) is a Research Training Group (Graduiertenkolleg) of the German Reseach Foundation (Deutsche Forschungsgemeinschaft, DFG), located in Berlin at sites of the Charité, MDC, and FMP.

  • Our 1st cohort PhD students will finish this year.

  • The 2nd cohort PhD students have started in October 2020.

Starting any time, we offer doctoral thesis projects for Charité medical students . For financing the necessary interception of the MSM study, the DFG provides one-year student grants. Applications or just information via tj-train@charite.de or by direct contact to the respective principal investigator.

That's all about:

Very briefly: The tight junction (TJ) connects neighbouring epithelial or endothelial cells and is the central element of barrier function, as it controls paracellular passage of solutes and water. Whether the TJ simply increases tightness or selectively mediates permeability varies greatly in different tissues and is determined by the TJ protein composition. TJs underlie extensive extra- and intracellular signalling, but also regulate epithelial functions and cellular differentiation. Furthermore, numerous TJ proteins serve as receptors for certain pathogens. Thus, TJ proteins are involved in the pathogenesis of numerous diseases. Alterations in TJ composition and architecture may e.g. cause unwanted leak flux or antigen passage and may thus maintain disease activity or even directly trigger disease onset.

More detailed   

Scientific meetings and events        Program Winter School 2020 (PDF)

Publications of the doctoral students

Projects and topics of theses 

     A:  Tight junction molecules, structure and function

Details

A1 

Dorothee Günzel*
Clinical Physiology / Nutritional Medicine, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin

"Impedance analysis of epithelial barrier properties"
PhD doctoral student, 2nd cohort: Saeed Khomeijani Farahani
PhD doctoral student, 1st cohort: Roman Mannweiler
MD doctoral student, 1st cohort: Ahmad Mouna

Details

A2

Jörg Piontek1*, Gerd Krause2
1Clinical Physiology / Nutritional Medicine, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin
2Structural Bioinformatics & Protein Design, Leibniz Research Institute of Molecular Pharmacology
(FMP), Berlin-Buch
"
Structure-based modification of Clostridium perfringens enterotoxin to target claudins"
PhD doctoral student, 2nd cohort: Ayk Waldow
PhD doctoral student, 1st cohort: Laura-Sophie Beier

Details

A3

Michael Fromm*, Jörg-Dieter Schulzke*
Clinical Physiology / Nutritional Medicine, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin
"Structural conditions of claudin-based water and cation channels"
PhD doctoral student, 2nd cohort: Fabián Martínez-Perafán
PhD doctoral student, 1st cohort: Carlos Ayala-Torres

Details

A4

Martin Lehmann, Volker Haucke*
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin-Buch
"Dynamic super-resolution imaging of tight junction components, lipids and Ions"
PhD doctoral student, 2nd cohort: Rozemarijn van der Veen
PhD doctoral student, 1st cohort: Hannes Gonschior

     B:  Tight junction development and regulation

Details

B1

Thomas Willnow*, Annette Hammes (Annabel Christ)
Max-Delbrück-Centrum für Molekulare Medizin (MDC), Berlin-Buch
"The endocytic receptor LRP2 serves as a central hub for dynamic cellular remodelling in neuronal stem cells and neural crest cells in the developing neural tube"
PhD doctoral student, 2nd cohort: Sher Min Mak
PhD doctoral student, 1st cohort: Izabela Kowalczyk

Details

B2

Michael Schumann1, Michael Hummel2*
1Medizinische Klinik m.S. Gastroenterologie, Infektiologie & Rheumatologie, Charité, CBF
2
Molecularpathology Section at the Institute of Pathology, Charité, CCM

"Loss of epithelial polarity as a mechanism in inflammation-induced carcinogenesis"
PhD doctoral student, 2nd cohort: Subhakankha (Victor) Manna
PhD doctoral student, 1st cohort: Danielle Cardoso-Silva

Details

B3

Dominik Müller*
Klinik für Pädiatrie m.S. Nephrologie, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum
"
Claudins of the thick ascending limb and nephrocalcinosis"
PhD doctoral student, 2nd cohort: Amr Al-Shebel
PhD doctoral student, 1st cohort: Murat Seker

Details

B4

Kai Schmidt-Ott*
Medizinische Klinik mit Schwerpunkt Nephrologie und Internistische Intensivmedizin, Charité - Universitätsmedizin Berlin and Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
"Systems level assessment of epithelial barriers in the kidney"
PhD doctoral student, 2nd cohort: Shuang Cao
PhD doctoral student, 1st cohort: Janna Leiz
MD doctoral student, 1st cohort: Alexander Holler

     C:  Tight junction modulation in disease

Details

C1

Jörg-Dieter Schulzke1*, Hanno Troeger2
1Clinical Physiology / Nutritional Medicine, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin
2Med. Klinik m.S. Gastroenterologie, Infektiologie & Rheumatologie, CBF, Charité - Universitätsmedizin Berlin
"Bacterial toxins’ impact on epithelial tight junctions"
PhD doctoral student, 2nd cohort: Martina Schneemann
PhD doctoral student, 1st cohort: Praveen Kumar Nattramilarasu
MD doctoral student, 1st cohort: Karem Awad
MD doctoral student, 1st cohort: Lucas Heils
MD doctoral student, 1st cohort: Sholpan Omarova
MD doctoral student, 1st cohort:
Eduard Butkevych

Details

C2

Susanne Krug*, Michael Fromm*
Clinical Physiology / Nutritional Medicine, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin
"Interaction of immune cells and TJ proteins in IBD"
PhD doctoral student, 2nd cohort: Lena Voges
PhD doctoral student, 1st cohort: Jia-Chen E. Hu

Details C3

Michael Schumann, Britta Siegmund*
Medizinische Klinik m.S. Gastroenterologie, Infektiologie & Rheumatologie, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin
"
Epithelial barrier function secondary to defective epithelial polarity – a mechanism in celiac disease initiation?"
PhD doctoral student, 2nd cohort: Violaine Dony
PhD doctoral student, 1st cohort: Deborah Delbue
MD doctoral student, 1st cohort: Daphni Siampli

Details

C4

Hans-Jörg Epple*, Thomas Schneider
Medizinische Klinik m.S. Gastroenterologie, Infektiologie & Rheumatologie, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin
"
Macromolecule uptake across the mucosa in HIV infection"
PhD doctoral student, 2nd cohort: Valerie Masete
PhD doctoral student, 1st cohort: Carolin Grünhagen
MD doctoral student, 1st cohort: Hannah Lutz

    * main GRK applicants

  Steering committee (12.2020)

- Jörg Schulzke, Rita Rosenthal (statutory members)
- Maria Balda, Markus Bleich (external members)
- Dorothee Günzel (PI member, elected by the students)
- Michael Fromm (PI member, elected by the PIs)
- Martin Lehmann (PI member, elected by the PIs)
-
Rozemarijn van der Veen (student member, elected by the students)
- Subhakankha (Viktor) Manna (student member, elected by the studentsr)

 

Impressum