Medizinische Klinik für Gastroenterologie, Infektiologie und Rheumatologie (einschl. Arbeitsbereich Ernährungsmedizin) CBF
 Clinical Physiology / Nutritional Medicine
Head:  Prof. Dr. Jörg D. Schulzke

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     Our profile

  "Physiology" we define by a central question: "How does it work?"

  For answering this question we apply several methods including molecular biology, electrophysiology, microbiology, biophysics, laser-scanning microscopy, and freeze-fracture electron microscopy

  We investigate all levels of the organism: molecules, cells, tissues, organs, and the whole body

  Our approach is translational as it combines basic research with topics related to diseases of the intestines, kidneys, nerves, and skin

  Main research topics are the tight junction and membrane channel molecules of the "intelligent borders of the body", the epithelia

  We perform numerous collaborative projects with colleagues from clinical departments

  Clinical Physiology / Nutritional Medicine is a unit within the Dept. of Gastroenterology, Rheumatology, and Infectious Diseases, located on the Campus Benjamin Franklin

News update    Blog archive

  • M. Fromm: Appointment as Editor-in-Chief for Section Physiology of Biology (Basel) (01.08.2023)

  • Chen JT*, Hu X* (*shared first authorship), Otto IUC, Schürger C, Rogalla von Bieberstein B, Doppler K, Krug SM, Hankir MK, Blasig R, Sommer C, Brack A, Blasig IE, Rittner HL (2023) Myelin barrier breakdown, mechanical hypersensitivity, and painfulness in polyneuropathy with claudin-12 deficiency. Neurobiol. Dis. 30: 106246, doi: 10.1016/j.nbd.2023.106246 (°IF 6.1)

  • Krug SM, Grünhagen C, Allers K, Bojarski C, Seybold J, Schneider T, Schulzke JD, Epple HJ (2023) Macromolecule translocation across the intestinal mucosa of HIV-infected patients by transcytosis and through apoptotic leaks. Cells 12(14): 1887 (13 pages). doi: 10.3390/cells12141887 (°IF 6.0)

  • Waldow A*, Beier LS* (*shared first authorship), Arndt J, Schallenberg S, Vollbrecht C, Bischoff P, Farrera-Sal M, Loch FN, Bojarski C, Schumann M, Winkler L, Kamphues C, Ehlen L°, Piontek J° (°shared last authorship) (2023) cCPE fusion proteins as molecular probes to detect claudins and tight junction dysregulation in gastrointestinal cell lines, tissue explants and patient-derived organoids. Pharmaceutics 15(7): 1980 (23 pages). doi: 10.3390/pharmaceutics15071980 (°IF 5.4)

  • Meoli L, Günzel D (2023) The role of claudins in homeostasis. Nat. Rev. Nephrol. (17 pages), doi: 10.1038/s41581-023-00731-y, free access: https://rdcu.be/de2J0 (°IF 41.5)

    •

Special Issues open for submission:

  • Fromm M, Krug SM, eds. (deadline Nov 30, 2023) "The tight junction and its proteins: From structure to pathologies" in Int. J. Mol. Sci. (°IF 5.6) Details

    •

  • Krug SM, ed. (deadline Mar 15, 2024) "Solving the puzzle: Molecular research in inflammatory bowel diseases 2.0" in Int. J. Mol. Sci. (°IF 5.6) Details

    •

Research topics
External collaborations
(*PhD) (°MD) (GRK)
  Staff Doctoral students  (*PhD) (°MD) (GRK)
Tight junctions and their proteins
- Claudin family
- TAMP family
- Angulin family

DFG Research Training Group 
"TJ-Train" GRK 2318
(Progenitor: DFG Research Unit 721)

   Jörg Schulzke,
Michael Fromm,
Dorothee Günzel,
Susanne Krug,
Luca Meoli,
Jörg Piontek,
Rita Rosenthal		   Surgery: Nina Hering
Physiology, Univ. Kiel: Susanne Milatz
Vet. Physiology FU Berlin: Salah Amasheh
Molecular structure
- Molec. structure of single claudins
- Molec. arrangement of heteromers
- Molec. structure of tricellulin		   Jörg Piontek,
Dorothee Günzel,
Susanne Krug, Santhosh Nagarajan		 Miriam Eichner*,
Caroline Hempel*,
Ayk Waldow* (A2), Laura-Sophie Beier* (A2)		 FMP Berlin-Buch: Gerd Krause
Physiology, Univ. Kiel: Susanne Milatz

Functional properties
- Barriers and ion channels
- Water channels
- Tricellular tight junction

   Michael Fromm,
Dorothee Günzel,
Susanne Krug,
Rita Rosenthal		 Fabian Martinez-Perafan* (A3), Carlos Ayala-Torres* (A3),
Dian Theune°		  
Diseases and pathologies
- Inflammatory bowel diseases
- Cytokines & interleukins
- Epithelial cancers

DFG Transregio-SFB TRR 241

   Jörg Schulzke,
Roland Bücker,
Susanne Krug		 Lena Voges* (C2)
Jia-Chen Hu* (C2)
Karem Awad°
Alice Itzlinger°
Tatjana Zejc°
Franziska Weiß* (B06)		 Gastroenterology: Michael Schumann, Christian Bojarski, Hans-Jörg Epple, Hanno Troeger, Deborah Delbue da Silva* (C3), Violaine Dony* (C3), Carolin Grünhagen* (C4), Valerie Masete* (C4), Hannah Lutz° (C4)
MDC: Izabela Kowalczyk* (B1)
- Pathogens and TJ

BMBF Consortium "PAC-CAMPY"

   Jörg Schulzke,
Roland Bücker,
Dorothee Günzel		 Eduard Butkevych°,
Fábia Lobo de Sá* (IP8),
Martina Schneemann* (C1), Praveen Nattramilarasu* (C1),
Luisa Reetz°		 Gastroenterology: Hans-Jörg Epple, Hanno Troeger
Surgery: Nina Hering
- Diets and nutrients
- Celiac disease		   Jörg Schulzke,
Rita Rosenthal,
Roland Bücker		   Gastroenterology: Michael Schumann
Independent researcher: Silke Zakrzewski
Pathol.+Gastroent.: Danielle Cardoso da Silva* (B2), Subhakankha (Victor) Manna* (B2)
 
- Claudins of the kidney
- FHHNC,  - Ca2+,  - Mg2+		   Dorothee Günzel,
Susanne Krug,
Luca Meoli		   Pediatric Nephrology: Dominik Müller, Tilman Breiderhoff, Murat Seker* (B3)
Nephrology: Janna Leiz* (B4), Alexander Holler° (B4)
Anatomy: Kerim Mutig
Physiology, Univ. Kiel: Susanne Milatz
 
- Pain reduction in peripheral nerve

DFG Klin. Forschungsgr. KFO 5001

 

   Susanne Krug Lukas Knobe* (P7) Anesthesiology Würzburg: Heike Rittner
Mechanisms
- Macromolecule permeation
- Drug absorption enhancers		   Susanne Krug,
Michael Fromm,
Rita Rosenthal		 Carolina Czichos° Anatomy, Univ. Jena: Jan Richter
Topics except TJ
- Epithelial Na+ channel (ENaC)
- Physiology of the eye		   Jörg Schulzke,
Michael Fromm,
Rita Rosenthal		   Independent doctor: Christian Barmeyer
Methods
- Impedance spectroscopy
- Electron microscopy
- Organoid culture		   Dorothee Günzel,
Susanne Krug,
Jörg Piontek,
In-Fah Lee		 Saeed Khomeijani Farahani* (A1), Roman Mannweiler* (A1)
Franziska Weiß* (B06)		 Anatomy: Sebastian Bachmann
FMP: Hannes Gonschior* (A4), Rozemarijn van der Veen* (A4)
 

 

 
History
The Institute of Clinical Physiology was founded in 1969 and chaired until 1995 by Klaus Hierholzer († 2007), followed by Michael Wiederholt. (1995-2002) and Michael Fromm (2002-2014, now appointed as Charité seniorprofessor).
Retired professors are Ulrich Hegel and Hans Ebel.
Present head of Clinical Physiology / Nutritional Medicine is Jörg D.Schulzke.
 

Address
The main building of the Campus Benjamin Franklin (CBF)
of the Charité - Universitätsmedizin Berlin		    University Hospital Benjamin Franklin (UKBF) pics
Address:    Clinical Physiology / Nutritional Medicine
Charité - Universitäsmedizin Berlin
Campus Benjamin Franklin
Hindenburgdamm 30
12203 Berlin (Steglitz), Germany
  Google Maps
Public transportation: Subway (U-Bahn "U9") or local train (S-Bahn "S1") 
to "Rathaus Steglitz", then change for bus 285 or M85, 
exit bus stop "Universitätsklinikum Benjamin Franklin"  Local map
Fares: Single ticket for 2 hrs, unlimited changes: "AB" 2.80 Euro
or, ONLY bus 285 or M85 from Rathaus Steglitz: "Kurzstrecke" 1.70 Euro  
   
Head:
 		 Professor Dr. med. Jörg D. Schulzke
joerg.schulzke@charite.de
Phone direct:
Phone Schulzke via secretary:		 +49 30 450-514531
+49 30 450-514522
Secretary:
 
Phone of secretary:		 Andreas Jantke
andreas.jantke@charite.de
+49 30 450-514522
FAX: +49 30 450-514962
   

Representative of the German Research Foundation
(DFG) at the Charité, Prof. Dr. Michael Fromm:

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