Our profile

  "Physiology" we define by a central question: "How does it work?"

  For answering this question we apply several methods including molecular biology, electrophysiology, microbiology, biophysics, laser-scanning microscopy, and freeze-fracture electron microscopy

  We investigate all levels of the organism: molecules, cells, tissues, organs, and the whole body

  Our approach is translational as it combines basic research with topics related to diseases of the intestines, kidneys, nerves, and skin

  Main research topics are the tight junction and membrane channel molecules of the "intelligent borders of the body", the epithelia

  We perform numerous collaborative projects with colleagues from clinical departments

  Clinical Physiology / Nutritional Medicine is a unit within the Dept. of Gastroenterology, Rheumatology, and Infectious Diseases, located on the Campus Benjamin Franklin

• New doctoral students: Janna Bleck, Amélie Moll

• Liebing E*, Krug SM* (*shared first authorship), Neurath MF, Siegmund B, Becker C (2024) Wall of resilience: How the intestinal epithelium prevents inflammatory onslaught in the gut. Cell. Mol. Gastroenterol. Hepatol. 18(#): ###### (## pages) doi:10.1016/j.jcmgh.2024.101423 (°IF 7.1) (Review)

• van der Veen RE, Piontek J, Bieck M, Saiti A, Gonschior H, Lehmann M (2024) Claudin-4 polymerizes after a small extracellular claudin-3-like substitution. J. Biol. Chem. 300(10): 107693 (14 pages). doi: 10.1016/j.jbc.2024.107693 (°IF 4.0)

• Heimesaat MM, Mousavi S, Lobo de Sá FD, Peh E, Schulzke JD, Bücker R, Kittler S, Bereswill S (2024) Oral curcumin ameliorates acute murine campylobacteriosis. Front Immunol. 15: 1363457 (14 pages). doi: 10.3389/fimmu.2024.1363457 (°IF 5.7)

• Nagarajan SK, Weber J, Roderer D, Piontek J (2024) C. perfringens enterotoxin-claudin pore complex: Models for structure, mechanism of pore assembly and cation permeability. bioRxiv preprint server https://www.biorxiv.org/content/10.1101/2024.08.02.605804v1