Medizinische Klinik für Gastroenterologie, Infektiologie und Rheumatologie (einschl. Arbeitsbereich Ernährungsmedizin) CBF
Clinical Physiology / Nutritional Medicine

Head:  Prof. Dr. Jörg D. Schulzke

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     Our profile

  "Physiology" we define by a central question: "How does it work?"

  For answering this question we apply several methods including molecular biology, electrophysiology, microbiology, biophysics, laser-scanning microscopy, and freeze-fracture electron microscopy

  We investigate all levels of the organism: molecules, cells, tissues, organs, and the whole body

  Our approach is translational as it combines basic research with topics related to diseases of the intestines, kidneys, nerves, and skin

  Main research topics are the tight junction and membrane channel molecules of the "intelligent borders of the body", the epithelia

  We perform numerous collaborative projects with colleagues from clinical departments

  Clinical Physiology / Nutritional Medicine is a unit within the Dept. of Gastroenterology, Rheumatology, and Infectious Diseases, located on the Campus Benjamin Franklin

News update    Blog archive
  • M. Fromm: Appointment as Editor-in-Chief for Section Physiology of Biology (Basel) (01.08.2023)

  • Chen JT*, Hu X* (*shared first authorship), Otto IUC, Schürger C, Rogalla von Bieberstein B, Doppler K, Krug SM, Hankir MK, Blasig R, Sommer C, Brack A, Blasig IE, Rittner HL (2023) Myelin barrier breakdown, mechanical hypersensitivity, and painfulness in polyneuropathy with claudin-12 deficiency. Neurobiol. Dis. 30: 106246, doi: 10.1016/j.nbd.2023.106246 (°IF 6.1)

  • Krug SM, Grünhagen C, Allers K, Bojarski C, Seybold J, Schneider T, Schulzke JD, Epple HJ (2023) Macromolecule translocation across the intestinal mucosa of HIV-infected patients by transcytosis and through apoptotic leaks. Cells 12(14): 1887 (13 pages). doi: 10.3390/cells12141887 (°IF 6.0)

  • Waldow A*, Beier LS* (*shared first authorship), Arndt J, Schallenberg S, Vollbrecht C, Bischoff P, Farrera-Sal M, Loch FN, Bojarski C, Schumann M, Winkler L, Kamphues C, Ehlen L°, Piontek J° (°shared last authorship) (2023) cCPE fusion proteins as molecular probes to detect claudins and tight junction dysregulation in gastrointestinal cell lines, tissue explants and patient-derived organoids. Pharmaceutics 15(7): 1980 (23 pages). doi: 10.3390/pharmaceutics15071980 (°IF 5.4)

  • Meoli L, Günzel D (2023) The role of claudins in homeostasis. Nat. Rev. Nephrol. (17 pages), doi: 10.1038/s41581-023-00731-y, free access: (°IF 41.5)

Special Issues open for submission:

  • Fromm M, Krug SM, eds. (deadline Nov 30, 2023) "The tight junction and its proteins: From structure to pathologies" in Int. J. Mol. Sci. (°IF 5.6) Details

  • Krug SM, ed. (deadline Mar 15, 2024) "Solving the puzzle: Molecular research in inflammatory bowel diseases 2.0" in Int. J. Mol. Sci. (°IF 5.6) Details

Research topics

External collaborations
(*PhD) (°MD) (GRK)
  Staff Doctoral students  (*PhD) (°MD) (GRK)
Tight junctions and their proteins
- Claudin family
- TAMP family
- Angulin family

DFG Research Training Group 
"TJ-Train" GRK 2318

(Progenitor: DFG Research Unit 721)

  Jörg Schulzke,
Michael Fromm,
Dorothee Günzel,
Susanne Krug,
Luca Meoli,
Jörg Piontek,
Rita Rosenthal
  Surgery: Nina Hering
Physiology, Univ. Kiel: Susanne Milatz
Vet. Physiology FU Berlin:
Salah Amasheh
Molecular structure
- Molec. structure of single claudins
- Molec. arrangement of heteromers
- Molec. structure of tricellulin
  Jörg Piontek,
Dorothee Günzel,
Susanne Krug,
Santhosh Nagarajan
Miriam Eichner*,
Caroline Hempel*,
Ayk Waldow* (A2), Laura-Sophie Beier* (A2)
FMP Berlin-Buch: Gerd Krause
Physiology, Univ. Kiel:
Susanne Milatz

Functional properties
- Barriers and ion channels
- Water channels
- Tricellular tight junction

  Michael Fromm,
Dorothee Günzel,
Susanne Krug,
Rita Rosenthal
Fabian Martinez-Perafan* (A3), Carlos Ayala-Torres* (A3),
Dian Theune°
Diseases and pathologies
- Inflammatory bowel diseases
- Cytokines & interleukins

- Epithelial cancers

DFG Transregio-SFB TRR 241

  Jörg Schulzke,
Roland Bücker,
Susanne Krug
Lena Voges* (C2)
Jia-Chen Hu* (C2)
Karem Awad°
Alice Itzlinger°
Tatjana Zejc
Franziska Weiß* (B06)
Gastroenterology: Michael Schumann, Christian Bojarski, Hans-Jörg Epple, Hanno Troeger, Deborah Delbue da Silva* (C3), Violaine Dony* (C3), Carolin Grünhagen* (C4), Valerie Masete* (C4), Hannah Lutz° (C4)
MDC: Izabela Kowalczyk* (B1)
Pathogens and TJ

BMBF Consortium "PAC-CAMPY"

  Jörg Schulzke,
Roland Bücker,
Dorothee Günzel
Eduard Butkevych°,
Fábia Lobo de Sá* (IP8),
Martina Schneemann* (C1), Praveen Nattramilarasu* (C1),
Luisa Reetz°
Gastroenterology: Hans-Jörg Epple, Hanno Troeger
Surgery: Nina Hering
- Diets and nutrients
- Celiac disease
  Jörg Schulzke,
Rita Rosenthal,
Roland Bücker
  Gastroenterology: Michael Schumann
Independent researcher: Silke Zakrzewski

Pathol.+Gastroent.: Danielle Cardoso da Silva* (B2), Subhakankha (Victor) Manna* (B2)
- Claudins of the kidney
- FHHNC,  - Ca2+,  - Mg2+
  Dorothee Günzel,
Susanne Krug,

Luca Meoli
  Pediatric Nephrology: Dominik Müller, Tilman Breiderhoff, Murat Seker* (B3)
: Janna Leiz* (B4), Alexander Holler° (B4)
Anatomy: Kerim Mutig
Physiology, Univ. Kiel:
Susanne Milatz

- Pain reduction in peripheral nerve

DFG Klin. Forschungsgr. KFO 5001


  Susanne Krug Lukas Knobe* (P7) Anesthesiology Würzburg: Heike Rittner
- Macromolecule permeation
- Drug absorption enhancers
  Susanne Krug,
Michael Fromm,
Rita Rosenthal
Carolina Czichos° Anatomy, Univ. Jena: Jan Richter
Topics except TJ
- Epithelial Na+ channel (ENaC)
- Physiology of the eye
  Jörg Schulzke,
Michael Fromm
Rita Rosenthal
  Independent doctor: Christian Barmeyer
- Impedance spectroscopy

- Electron microscopy

- Organoid culture
  Dorothee Günzel,
Susanne Krug,
Jörg Piontek
In-Fah Lee
Saeed Khomeijani Farahani* (A1), Roman Mannweiler* (A1)
Franziska Weiß* (B06)
Anatomy: Sebastian Bachmann
FMP: Hannes Gonschior*
(A4), Rozemarijn van der Veen* (A4)



The Institute of Clinical Physiology was founded in 1969 and chaired until 1995 by Klaus Hierholzer ( 2007), followed by Michael Wiederholt. (1995-2002) and Michael Fromm (2002-2014, now appointed as Charité seniorprofessor).
Retired professors are Ulrich Hegel and Hans Ebel.
Present head of Clinical Physiology / Nutritional Medicine is Jörg D.Schulzke.


The main building of the Campus Benjamin Franklin (CBF)
of the Charité - Universitätsmedizin Berlin
   University Hospital Benjamin Franklin (UKBF) pics
Address:    Clinical Physiology / Nutritional Medicine
Charité - Universitäsmedizin Berlin
Campus Benjamin Franklin
Hindenburgdamm 30
12203 Berlin (Steglitz), Germany
  Google Maps
Public transportation: Subway (U-Bahn "U9") or local train (S-Bahn "S1") 
to "Rathaus Steglitz", then change for bus 285 or M85, 
exit bus stop "Universitätsklinikum Benjamin Franklin"  Local map
Fares: Single ticket for 2 hrs, unlimited changes: "AB" 2.80 Euro
or, ONLY bus 285 or M85 from Rathaus Steglitz: "Kurzstrecke" 1.70 Euro  
Professor Dr. med. Jörg D. Schulzke
Phone direct:
Phone Schulzke via secretary:
+49 30 450-514531
+49 30 450-514522
Phone of secretary:
Andreas Jantke
+49 30 450-514522
FAX: +49 30 450-514962

Representative of the German Research Foundation
(DFG) at the Charité, Prof. Dr. Michael Fromm:

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