Medizinische Klinik für Gastroenterologie, Infektiologie und Rheumatologie (einschl. Arbeitsbereich Ernährungsmedizin) CBF Clinical Physiology / Nutritional Medicine

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Publications focused on kidney, since 2002 >All ClinPhysio papers       >Personal Lists       If paper not accessible, mail for a reprint

• Pouyiourou I, Fromm A, Piontek J, Rosenthal R, Furuse M*, Günzel D* (*shared last authorship) (2024) Permeability profiles of renal paracellular channel-forming claudins. Acta Physiol. ### (°IF 5.6) (accepted 13.12.2024)

• Tsamo Tetou A, Günzel D (2024) The role of claudins in renal transepithelial transport and kidney disease. Curr. Opin. Nephrol. Hypertens. 33(5): 535-542 (°IF 2.2) (Review) (accepted)

• Pfeffer T*, Krug SM* (*shared first authorship), Kracke T, Schürfeld R, Colbatzky F, Kirschner P, Medert R, Freichel M, Schumacher D, Bartosova M, Zarogiannis SG, Muckenthaler MU, Altamura S, Pezer S, Volk N, Schwab C, Duensing S, Fleming T, Heidenreich E, Zschocke J, Hell R, Poschet G, Schmitt CP°, Peters V° (°shared last authorship) (2024) Knock-out of dipeptidase CN2 in human proximal tubular cells disrupts dipeptide and amino acid homeostasis and para- and transcellular solute transport. Acta Physiol. 240(4): e14126 (20 pages), doi: 10.1111/apha.14126 (°IF 5.6)

• Meoli L, Günzel D (2023) The role of claudins in homeostasis. Nat. Rev. Nephrol. (17 pages), doi: 10.1038/s41581-023-00731-y, free access: https://rdcu.be/de2J0 (IF 28.6)

• Wuttke M, König E, Katsara MA, Kirsten H, Khomeijani Farahani S, Teumer A, Li Y, Lang M, Göçmen B, Pattaro C, Günzel D, Köttgen A, Fuchsberger C (2023) Imputation-powered whole-exome analysis identifies genes associated with kidney function and disease in the UK Biobank. Nat. Commun. 14: 1287 (16 pages), doi: 10.1038/s41467-023-36864-8 (IF 14.7)

• Kriuchkova N, Breiderhoff T, Müller D, Yilmaz DE, Demirci H, Drewell H, Günzel D, Himmerkus N, Bleich M, Persson PB, Mutig K (2023) Furosemide rescues hypercalciuria in familial hypomagnesaemia with hypercalciuria and nephrocalcinosis model. Acta Physiol. 237(3): e13927 (16 pages), doi: 10.1111/apha.13927 (IF 5.6)

• Günzel D (2022) Is there a molecular basis for solvent drag in the renal proximal tubule? Pflügers Arch. Eur. J. Physiol. 475(2): 277-281 (5 pages), doi: 10.1007/s00424-022-02773-w (IF 4.5)

• Quintanova C*, Himmerkus N*  (*shared first authorship), Svendsen SL, von Schwerdtner O, Merkel C, Pinckert L, Mutig K, Breiderhoff T, Müller D, Günzel D, Bleich M (2022) Unrecognized role of claudin-10b in basolateral membrane infoldings of the thick ascending limb. Ann. NY Acad. Sci. 1517(1): 266-278, doi: org/10.1111/nyas.14882 (IF 5.2)

• Breiderhoff T*, Himmerkus N*  (*shared first authorship), Meoli L, Fromm A, Sewerin S, Kriuchkova N, Nagel O, Ladilov Y, Krug SM, Quintanova C, Stumpp M, Garbe-Schönberg  D, Westernströer U, Merkel C, Brinkhus MA, Altmüller J, Schweiger MR, Müller D, Mutig K, Morawski M, Halbritter J, Milatz S, Bleich M*, Günzel D* (*shared last authorship) (2022) Claudin-10a deficiency shifts proximal tubular Cl^- permeability to cation selectivity via claudin-2 redistribution. J. Am. Soc. Nephrol. 33(4): 699-717, doi: 10.1681/ASN.2021030286  (IF 13.6)

• Sewerin S, Piontek J, Schönauer R, Grunewald S, Rauch A, Neuber S, Bergmann C, Günzel D*, Halbritter J* (*shared last authorship) (2022) Defective claudin-10 causes a novel variation of HELIX syndrome through compromised tight junction strand assembly. Genes & Dis. 9(5): 1301-1314. doi: 10.1016/j.gendis.2021.06.006 (IF 6.8)

• Alzahrani AS, Hussein M, Alswailem M, Mouna A, Albalawi L, Moria Y, Jabbar MA, Shi Y, Günzel D*, Dasouki M* (*equally contributing) (2021) A novel claudin-10 mutation with a unique mechanism in two unrelated families with HELIX syndrome. Kidney Int. 100(2): 415-429, doi: 10.1016/j.kint.2021.02.023, Supplement (IF 19.0)

• Ayala-Torres C, Krug SM, Rosenthal R*, Fromm M* (*shared last authorship) (2021) Angulin-1 (LSR) affects paracellular water transport, however only in tight epithelial cells. Int. J. Mol. Sci. (SI “Membrane Proteins: Structure, Function and Motion”) 22: 7827 (25 pages). doi: 10.3390/ijms22157827 (IF 6.2)

• Hempel C, Protze J, Altun E, Riebe B, Piontek A, Fromm A, Lee IM, Saleh T, Günzel D, Krause G, Piontek J (2020) Assembly of tight junction strands: Claudin-10b and claudin-3 form homo-tetrameric building blocks that polymerise in a channel-independent manner. J. Mol. Biol. 432(7): 2405-2427 (IF 5.5) [PubMed] [WebPage] [PDF] [Supplementary Figures S1-S11] [Supplementary Table S1]

• Ayala-Torres C, Krug SM, Schulzke JD, Rosenthal R*, Fromm M* (*shared last authorship) (2019) Tricellulin effect on paracellular water transport. Int. J. Mol. Sci. 220(22): 5700 (15 pages) (IF 4.6) [PubMed] [WebPage] [PDF]

• Breiderhoff T*°, Himmerkus N* (shared first authorship), Drewell H, Plain A, Günzel D, Mutig K, Willnow TE, Müller D°, Bleich M° (°corresponding) (2018) Deletion of claudin-10 rescues claudin-16-deficient mice from hypomagnesmia and hypercalciuria. Kidney Int. 93(3): 580-588 (IF 8.3) [PubMed] [WebSite] [PDF]

• Klar J, Piontek J, Milatz S, Tariq M, Jameel M, Breiderhoff T, Schuster J, Fatima A, Asif M, Sher M, Mäbert K, Fromm A, Baig SM, Günzel D, Dahl N (2017) Altered paracellular cation permeability due to a rare CLDN10B variant causes anhidrosis and kidney damage. Plos Genet. 13(7): e1006897 (pages 1-22 + 6 Supplements) (IF 5.5) [PubMed] [WebPage] [PDF] [Supplement]

• Fromm M, Piontek J, Rosenthal R, Günzel D, Krug SM (2017) Tight junctions of the proximal tubule and their channel proteins. Pflügers Arch. 469(7-8): 877-887 (IF 2.8)  [PubMed] [WebPage] [PDF] Review

• Milatz S, Piontek J, Hempel C, Meoli L, Grohe C, Fromm A, Lee IM, El-Athman R, Günzel D (2017) Tight junction strand formation by claudin-10 isoforms and claudin-10a/-10b chimeras. Ann. N.Y. Acad. Sci. 1405: 102-115 (IF 4.3) [PubMed] [WebPage] [PDF]

• Milatz S*, Himmerkus N* (*shared first authorship), Wulfmeyer VC, Drewell H, Mutig K, Hou J, Breiderhoff T, Müller D, Fromm M, Bleich M°, Günzel D° (°shared last authorship) (2017) Mosaic expression of claudins in thick ascending limbs of Henle results in spatial separation of paracellular Na⁺ and Mg²⁺ transport. Proc. Natl. Acad. Sci. USA 114(2): E219-E227 (IF 9.5) [PubMed] [WebPage] [PDF+Supplement]. "Paper of the month" 03/2017 of the German Physiological Society

• Milatz S, Breiderhoff T (2017) One gene, two paracellular ion channels ‒ claudin-10 in the kidney. Pflügers Arch. 469(1): 115-121 (IF 2.8) [PubMed] [WebPage] [PDF] Review

• Rosenthal R, Günzel D, Krug SM, Schulzke JD, Fromm M, Yu ASL (2017) Claudin-2-mediated cation and water transport share a common pore. Acta Physiol. 219(2): 521-536 (IF 5.9) [PubMed] [WebPage] [PDF]

• Conrad MP*, Piontek J* (*shared first authorship), Günzel D, Fromm M, Krug SM (2016) Molecular basis of claudin-17 anion selectivity. Cell. Mol. Life Sci. 73(1): 185-200 (IF 5.8) [PubMed] [WebPage] [PDF] [Supplement]

• Aue A*, Hinze C* (*shared first authorship), Ruffert J, Yurtdas Y, Werth M, Chen W, Walentin K, Rabien A, Kilic E, Schulzke JD, Schumann M, Schmidt-Ott KM (2015) A novel grainyhead-like 2/ovo-like 2 pathway regulates renal epithelial barrier function and lumen expansion. J. Am. Soc. Nephrol. 26(11): 2704-2715 (IF 8.5) [PubMed] [WebPage] [PDF] [Supplement]

• Rosenthal R, Fromm M (2014) Significant water absorption goes paracellular in kidney proximal tubules. Am. J. Physiol. Renal Physiol. 306(1): F51-F52 (IF 3.2)  [PubMed] [WebPage] [PDF] [Invited Editorial]

• Günzel D, Yu AS (2013) Claudins and the modulation of tight junction permeability. Physiol. Rev. 93(2): 525-569 (IF 30.2) [PubMed] [WebPage] [PDF]

• Krug SM, Günzel D, Conrad MP, Rosenthal R, Fromm A, Amasheh S, Schulzke JD, Fromm M (2012) Claudin-17 forms tight junction channels with distinct anion selectivity. Cell. Mol. Life Sci. 69(16): 2765-2778 (IF 6.6) [PubMed] [WebPage] [PDF] [Supplement]

• Rosenthal R, Milatz S, Krug SM, Oelrich B, Schulzke JD, Amasheh S, Günzel D, Fromm M (2010) Claudin-2, a component of the tight junction, forms a paracellular water channel. J. Cell Sci. 123(11): 1913-1921 (IF 6.3) [PubMed] [WebPage] [PDF] [Supplement]

• Günzel D, Amasheh S, Pfaffenbach S, Richter JF, Kausalya PJ, Hunziker W, Fromm M (2009) Claudin-16 affects transcellular Cl^- secretion in MDCK cells. J. Physiol. (Lond.) 587(15): 3777-3793 (IF 4.8) [PubMed] [WebPage] [PDF] [Supplement]

• Günzel D, Stuiver M, Kausalya PJ, Haisch L, Krug SM, Rosenthal R, Meij IC, Hunziker W, Fromm M, Müller D (2009) Claudin-10 exists in six alternatively spliced isoforms which exhibit distinct localization and function. J. Cell Sci. 122: 1507-1517 (IF 6.1) [PubMed] [WebPage] [PDF]

• Krug SM, Amasheh S, Richter JF, Milatz S, Günzel D, Westphal JK, Huber O, Schulzke JD, Fromm M (2009) Tricellulin forms a barrier to macromolecules in tricellular tight junctions without affecting ion permeability. Mol. Biol. Cell 20: 3713-3724 (IF 6.0) [PubMed] [WebPage] [PDF] [Supplement text] [Supplement video]

• Yu ASL, Cheng MH, Angelow S, Günzel D, Kanzawa SA, Schneeberger EE, Fromm M, Coalson RD (2009) Molecular basis for cation selectivity in claudin-2-based paracellular pores: Identification of an electrostatic interaction site. J. Gen. Physiol. 133(1): 111-127 (IF 4.3) [PubMed] [WebPage] [PDF]

• Kausalya PJ*, Amasheh S* (*shared first authorship), Günzel D, Wurps H, Müller D, Fromm M, Hunziker W (2006) Disease-associated mutations affect intracellular traffic and paracellular Mg²⁺ transport function of claudin-16. J. Clin. Invest. 116(4): 878-891 [PubMed] [WebPage] [PDF]

• Amasheh S, Schmidt T, Mahn M, Florian P, Mankertz J, Tavalali S, Gitter AH, Schulzke JD, Fromm M (2005) Contribution of claudin-5 to barrier properties in tight junctions of epithelial cells. Cell Tiss. Res. 321(1): 89-96 [PubMed] [WebPage] [PDF]

• Bojarski C, Weiske J, Schöneberg T, Schröder W, Mankertz J, Schulzke JD, Florian P, Fromm M, Tauber R, Huber O (2004) The specific fate of tight junction proteins in apoptotic epithelial cells. J. Cell Sci. 117: 2097-2107 [PubMed] [WebPage] [PDF]

• Amasheh S, Meiri N, Gitter AH, Schöneberg T, Mankertz J, Schulzke JD, Fromm M (2002) Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells. J. Cell Sci. 115(24): 4969-4976 [PubMed] [WebPage] [PDF]

Textbook chapters on kidney physiology

• Fromm M, Gaebel G (2015) chapter 13: "Niere" [Kidney], In: Physiologie der Haustiere. von Engelhardt W, Breves G, Diener M, Gäbel G (eds), 5^th fully revised edn, MVS Medizinverlage / Enke, Stuttgart, p 292-320, ISBN: 9783830412595 [Publisher's ad] [Textbook of veterinary physiology]

• Fromm M, Gaebel G (2009) chapter 13: "Niere" [Kidney], In: Physiologie der Haustiere. Engelhardt W von (ed), 3rd fully revised edn, Enke Verlag, Stuttgart, p 292-320 [Publishers ad] [Textbook of veterinary physiology]

• Fromm M, Gaebel G (2005) Chapter 13: "Niere", In: Physiologie der Haustiere. Engelhardt W von, Breves G (Hrsg.), 2. Auflage, Enke Verlag, Stuttgart, p 277-303 [Textbook of veterinary physiology] [Publisher's ad]

• Fromm M, Hierholzer K (2000) "Niere". In: Physiologie der Haustiere. W.v. Engelhardt, G. Breves (eds.), 1st edition, Enke, Stuttgart, chapter 12, p 254-288 [Textbook of veterinary physiology]

• Lang F, Fromm M (2000) Chapter 35: "Funktionen der Niere", In: Physiologie des Menschen. R.F. Schmidt, G. Thews, F. Lang, eds., 28. Auflage, Springer, Berlin Heidelberg New York, pp 737-776 [Textbook of physiology] [Verlagsprospekt / publisher's ad].

• Hierholzer K, Fromm M (1995, 1997) "Funktionen der Niere". In: Physiologie des Menschen. Kapitel 35, R.F. Schmidt und G. Thews eds., 26. und 27. Auflage, Springer, Berlin Heidelberg New York, pp 737-776 [Textbook of physiology].