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2024
Pouyiourou I, Fromm A, Piontek J, Rosenthal R, Furuse M*, Günzel D* (*shared last authorship) (2024) Permeability profiles of renal paracellular channel-forming claudins. Acta Physiol. ### (°IF 5.6) (accepted 13.12.2024)
Daci D*, Altrichter S* (*shared first authorship), Grillet F, Dib S, Mouna A, Suresh Kumar S, Terhorst-Molawi D, Maurer M, Günzel D°, Jörg Scheffel J° (°shared last authorship) (2024) Altered sweat composition due to changes in tight junction expression of sweat glands in cholinergic urticaria patients. Int. J. Mol. Sci. 25(9): 4658 (16 pages), doi: 10.3390/ijms25094658 (°IF 4.9)
Alija C,
Knobe L,
Pouyiourou I,
Furuse M,
Rosenthal R,
Günzel D
(2024) Integrating continuous transepithelial flux measurements into an Ussing chamber set-up.
Int. J. Mol. Sci.
25(4): 2252 (13 pages),
doi: 10.3390/ijms25042252
(°IF 4.9)
Review
Tsamo Tetou A, Günzel D (2024) The role of claudins in renal transepithelial transport and kidney disease. Curr. Opin. Nephrol. Hypertens. 33(5): 535-542 (8 pages), doi: 10.1097/mnh.0000000000001003 (°IF 2.2)
2023
Wuttke M, König E, Katsara MA, Kirsten H, Khomeijani Farahani S
Kriuchkova N, Breiderhoff T, Müller D, Yilmaz DE, Demirci H, Drewell H, Günzel D, Himmerkus
N, Bleich M, Persson PB, Mutig K (2023) Furosemide rescues hypercalciuria in familial hypomagnesaemia with hypercalciuria and nephrocalcinosis model.
Acta Physiol.
237(3): e13927 (16 pages), doi: 10.1111/apha.13927
(IF 5.6) Review
Meoli L, Günzel D (2023) The role of claudins in homeostasis. Nat. Rev. Nephrol. ((17 pages), doi: 10.1038/s41581-023-00731-y, free access: https://rdcu.be/de2J0 (IF 28.6)
Günzel D (2023) Is there a molecular basis for solvent drag in the renal proximal tubule?
2022
Beier LS*, Waldow A* (*shared first authorship), Khomeijani Farahani S, Mannweiler R, Vidal-Y-Sy S, Brandner JM, Piontek J°, Günzel D° (°shared last authorship) (2022) Claudin targeting as an effective tool for directed barrier modulation of the viable epidermis. Ann. NY Acad. Sci. 1517(1): 251-265, doi: 10.1111/nyas.14879 (IF 5.2)
Breiderhoff T*, Himmerkus N* (*shared first authorship), Meoli L, Fromm A, Sewerin S, Kriuchkova N, Nagel O, Ladilov Y, Krug SM, Quintanova C, Stumpp M, Garbe-Schönberg D, Westernströer U, Merkel C, Brinkhus MA, Altmüller J, Schweiger MR, Müller D, Mutig K, Morawski M, Halbritter J, Milatz S, Bleich M*, Günzel D* (*shared last authorship) (2022) Claudin-10a deficiency shifts proximal tubular Cl- permeability to cation selectivity via claudin-2 redistribution. J. Am. Soc. Nephrol. 33(4): 699-717, doi: 10.1681/ASN.2021030286 (IF 13.6)
Sewerin S, Piontek J, Schönauer R, Grunewald S, Rauch A, Neuber S, Bergmann C, Günzel D*, Halbritter J* (*shared last authorship) (2022) Defective claudin-10 causes a novel variation of HELIX syndrome through compromised tight junction strand assembly. Genes & Dis. 9(5): 1301-1314. doi: 10.1016/j.gendis.2021.06.006 (IF 6.8)
Gonschior H, Schmied C, Van der Veen R, Eichhorst J, Himmerkus N, Piontek J, Günzel D, Bleich M, Furuse M, Haucke V, Lehmann M (2022) Nanoscale segregation of channel and barrier claudins enables paracellular ion flux. Nat. Commun. 13(1): 4985 (20 pages). doi: 10.1038/s41467-022-32533-4, Supplement (IF 16.6)
Hempel C*, Rosenthal R* (*shared first authorship), Fromm A, Krug SM, Fromm M, Günzel D, Piontek J (2022) Tight junction channels claudin-10b and claudin-15: Functional mapping of pore-lining residues. Ann. NY Acad. Sci. 1515(1): 129-142, doi: 10.1111/nyas.14794 (IF 5.2)
Quintanova C*, Himmerkus N* (*shared first authorship), Svendsen SL, von Schwerdtner O, Merkel C, Pinckert L, Mutig K, Breiderhoff T, Müller D, Günzel D, Bleich M (2022) Unrecognized role of claudin-10b in basolateral membrane infoldings of the thick ascending limb. Ann. NY Acad. Sci. 1517(1): 266-278, doi: org/10.1111/nyas.14882 (IF 5.2)
Schindler B, Günzel D, Schmid T (2021) Transcending two-path impedance spectroscopy with machine learning: A computational study on modeling and quantifying electric bipolarity of epithelia. Int. J. Adv. Life Sci. 13(3-4), 134-148, https://www.iariajournals.org/life_sciences/tocv13n12.html)
Wang Y, Scheffel J, Vera CA, Liu W, Günzel D, Terhorst-Molawi D, Maurer M, Altrichter S (2022) Impaired sweating in patients with cholinergic urticaria is linked to low expression of acetylcholine receptor CHRM3 and acetylcholine esterase in sweat glands. Front Immunol. 13: 955161 (11 pages). doi: 10.3389/fimmu.2022.955161, Supplements (IF 7.3)
2021
Alzahrani AS, Hussein M, Alswailem M, Mouna A, Albalawi L, Moria Y, Jabbar MA, Shi Y, Günzel D*, Dasouki M* (*shared last authorship) (2021) A novel claudin-10 mutation with a unique mechanism in two unrelated families with HELIX syndrome. Kidney Int. 100(2): 415-429, doi: 10.1016/j.kint.2021.02.023, Supplement (IF 19.0)
Mannweiler R, Bergmann S, Vidal-Y-Sy S, Brandner JM, Günzel D (2021) Direct assessment of individual skin barrier components by electrical impedance spectroscopy. Allergy 76(10): 3094-3106 (13 pages). doi: 10.1111/all.14851, Supplement PDF (IF 14.7)
2020
Bücker R, Zakrzewski SS, Wiegand S, Pieper R, Fromm A, Fromm M, Günzel D, Schulzke JD (2020) Zinc prevents intestinal epithelial barrier dysfunction induced by alpha-hemolysin-producing Escherichia coli 536 infection in porcine colon. Vet. Microbiol. 243: 108632 (6 pages) [PubMed] [WebPage] [PDF] [Supplement] (IF 3.3)
Hempel C, Protze J, Altun E, Riebe B, Piontek A, Fromm A, Lee IM, Saleh T, Günzel D, Krause G, Piontek J (2020) Assembly of tight junction strands: Claudin-10b and claudin-3 form homo-tetrameric building blocks that polymerize in a channel-independent manner. J. Mol. Biol. 432(7): 2405-2427 (IF 5.5) [PubMed] [WebPage] [PDF] [Supplementary Figures S1-S11] [Supplementary Table S1]
Louer EMM, Günzel D, Rosenthal R, Yi G, Stunnenberg H, den Hollander AI, Deen PMT (2020) Differential day-night expression of tight junction components in murine retinal pigment epithelium. Exp. Eye Res. 193: 107985 (9 pages) (IF 3.5) [PubMed] [WebPage] [PDF]
Rosenthal R, Günzel D, Piontek J, Krug SM, Ayala-Torres C, Hempel C, Theune D, Fromm M (2020) Claudin-15 forms a water channel through the tight junction with distinct function compared to claudin-2. Acta Physiol. 228(1): e13334 (15 pages) (IF 6.3) [PubMed] [WebPage] [PDF]
(Editorial Commentary on this article: Alexander RT (2020) Claudin-15 is not a drag! Acta Physiol. 228(1): e13397 [PubMed] [WebPage] [PDF])
Review
Meoli L, Günzel D (2020) Channel functions of claudins in the organization of biological systems. BBA - Biomembranes 1862(9): 183344 (18 pages) (°IF 3.7) [Part of Special Volume "The vertebrate epithelial apical junctional complex", Hervé JC ed.] [PubMed] [WebPage] [PDF] [Supplementary Fig. S1]
2019
Knöpfel T, Himmerkus N, Günzel D, Bleich M, Hernando N, Wagner C (2019) Paracellular transport of phosphate along the intestine. Am. J. Physiol. Gastointest. Liver Physiol. 317(2): G233-G241 (IF 3.7) [PubMed] [WebPage] [PDF]
Ebel H, Fromm A, Günzel D, Fromm M, Schulzke JD (2019) Phospholipid effects on SGLT1-mediated glucose transport in rabbit ileum brush border membrane vesicles. Biochim. Biophys. Acta - Biomembranes 1861(10): 182985 (pages 1-8) (IF 3.4) [PubMed] [WebPage] [PDF]
Dietrich J, Grass I, Günzel D, Herek S, Braeuning A, Lampen A, Hessel-Pras S (2019) The marine biotoxin okadaic acid affects intestinal tight junction proteins in human intestinal cells. Toxicol. vitro 58: 150-160 (IF 3.0) [PubMed] [WebPage]
Ostermann AL, Wunderlich CM, Schneiders L, Vogt MC, Woeste MA, Belgardt BF, Niessen CM, Martiny B, Schauss AC, Frommholt P, Nikolaev A, Hövelmeyer N, Sears RC, Koch PJ, Günzel D, Brüning JC, Wunderlich FT (2019) Intestinal insulin/IGF1 signalling through FoxO1 regulates epithelial integrity and susceptibility to colon cancer. Nat. Metab. 1: 371-389 (new journal, no IF yet) [no PubMed yet] [WebPage] [PDF]
2018
Rabbani I*, Braun HS* (* shared first authorship), Akhtar T, Liebe F, Rosendahl J, Grunau M, Tietjen U, Masood S, Kaessmeyer S, Günzel D, Rehman H, Stumpff F (2018) A comparative study of ammonia transport across ruminal epithelia in Bos indicus crossbreds versus Bos taurus. Animal Sci. J. 89(12): 1692-1700 (IF 1.3) [PubMed] [WebPage] [PDF]
Breiderhoff T*°, Himmerkus N* (shared first authorship), Drewell H, Plain A, Günzel D, Mutig K, Willnow TE, Müller D°, Bleich M° (°corresponding) (2018) Deletion of claudin-10 rescues claudin-16-deficient mice from hypomagnesmia and hypercalciuria. Kidney Int. 93(3): 580-588 (IF 8.3) [PubMed] [WebSite] [PDF]
Maares M, Keil C, Thomsen S, Günzel D, Wiesner B, Haase H (2018) Characterization of Caco-2 cells stably expressing the protein-based zinc probe eCalwy-5 as a model system for investigating intestinal zinc transport. J. Trace Elem. Med. Biol. 49: 296-304 (IF 2.9) [PubMed] [WebPage] [PDF]
Conference Proceeding
Schmid T, Günzel D, Bogdan M (2018) Automated quantification of the resistance of epithelial cell layers from an impedance spectrum. BIOTECHNO 2018, p. 8-13 [PDF] Selected as best paper of the conference [Award]
2017
Milatz S*, Himmerkus N* (*shared first authorship), Wulfmeyer VC, Drewell H, Mutig K, Hou J, Breiderhoff T, Müller D, Fromm M, Bleich M°, Günzel D° (°shared last authorship) (2017) Mosaic expression of claudins in thick ascending limbs of Henle results in spatial separation of paracellular Na+ and Mg2+ transport. Proc. Natl. Acad. Sci. USA 114(2): E219-E227 (IF 9.5) [PubMed] [WebPage] [PDF+Supplement]
. "Paper of the month" 03/2017 of the German Physiological SocietyMilatz S, Piontek J, Hempel C, Meoli L, Grohe C, Fromm A, Lee IM, El-Athman R, Günzel D (2017) Tight junction strand formation by claudin-10 isoforms and claudin-10a/-10b chimeras. Ann. N.Y. Acad. Sci. 1405: 102-115 (IF 4.3) [PubMed] [WebPage] [PDF]
Kern M, Günzel D, Aschenbach JR, Tedin K, Bondzio A, Lodemann U (2017) Altered cytokine expression and barrier properties after in vitro infection of porcine epithelial cells with enterotoxigenic Escherichia coli and probiotic Enterococcus faecium. Mediators Inflamm. 2017: 2748192 (13 pages) (IF 3.5) [PubMed] [WebPage] [PDF]
Klar J, Piontek J, Milatz S, Tariq M, Jameel M, Breiderhoff T, Schuster J, Fatima A, Asif M, Sher M, Mäbert K, Fromm A, Baig SM, Günzel D, Dahl N (2017) Altered paracellular cation permeability due to a rare CLDN10B variant causes anhidrosis and kidney damage. Plos Genet. 13(7): e1006897 (pages 1-22 + 6 Supplements) (IF 5.5) [PubMed] [WebPage] [PDF] [Supplement]
Meissner S, Hagen F, Deiner C, Günzel D, Greco G, Shen Z, Aschenbach JR (2017) Key role of short chain fatty acids in epithelial barrier failure during ruminal acidosis. J. Dairy Sci.
Piontek A, Rossa J, Protze J, Wolburg H, Hempel C, Günzel D, Krause G, Piontek J (2017) Polar and charged extracellular residues conserved among sealing claudins contribute to tight junction strand formation. Ann. N.Y. Acad. Sci. 1397(1): 143-156 (IF 4.3) [PubMed] [WebPage] [PDF]
Rosenthal R, Günzel D, Krug SM, Schulzke JD, Fromm M, Yu ASL* (2017) Claudin-2-mediated cation and water transport share a common pore. Acta Physiol. 219(2): 521-536 (IF 5.9)
Wiegand S, Zakrzewski SS, Eichner M, Schulz E, Günzel D, Pieper R, Rosenthal R, Barmeyer C, Bleich A, Dobrindt U, Schulzke JD*, Bücker R* (*shared last authorship) (2017) Zinc treatment is efficient against Escherichia coli α haemolysin-induced intestinal leakage in mice. Sci. Rep. 7: 45649 (pages 1-13) (IF 4.1) [PubMed] [WebPage] [PDF]
Reviews
Günzel D (2017) Claudins: vital partners in trans- and paracellular transport coupling. Pflügers Arch. 469(1): 35-44 (IF 2.8) [PubMed] [WebPage] [PDF]
Fromm M, Piontek J, Rosenthal R, Günzel D, Krug SM (2017) Tight junctions of the proximal tubule and their channel proteins. Pflügers Arch. 469(7-8): 877-887 (IF 2.8)
Rosenthal R, Czichos C, Theune D, Günzel D, Schulzke JD, Fromm M (2017) Water channels and barriers formed by claudins. Ann. N.Y. Acad. Sci.
Editorial
Bleich M, Günzel D
(2017) Physiology, pathophysiology, and clinical impact of claudins.
Pflügers Arch.
469(1): 1-2
(IF 2.8)
[PubMed] [WebPage]
[PDF] Editions
Bleich M, Günzel D, Issue Editors (2017) Physiology, pathophysiology, and clinical impact of claudins. Special Issue of Pflügers Arch. 469(1): 1-158 (IF 2.8) [Contents w. links to papers]
Fromm M, Günzel D, Schulzke JD, Issue Editors (2017) Tight junctions and their proteins, I. Ann. N.Y. Acad. Sci. 1397: 1-230 (IF 4.3) [Contents w. links to papers]
Schulzke JD, Günzel D, Fromm M, Issue Editors (2017) Tight junctions and their proteins, II. Ann. N.Y. Acad. Sci. 1405: 1-214 (IF 4.3) [Contents w. links to papers]
2016
Conrad MP*, Piontek J* (*shared first authorship), Günzel D, Fromm M, Krug SM (2016) Molecular basis of claudin-17 anion selectivity. Cell. Mol. Life Sci. 73(1): 185-200 (IF 5.9) [PubMed] [WebPage] [PDF] [Supplement]
2015
Milatz S, Piontek J, Schulzke JD, Blasig IE, Fromm M, Günzel D (2015) Probing the cis-arrangement of prototype tight junction proteins claudin-1 and claudin-3. Biochem. J. 468(3): 449-458 (IF 3.6)
[PubMed] [WebPage] [PDF]Winkelbach A, Günzel D, Schulz C, Wuertz (2105) Differences in IgY gut absorption in gastric rainbow trout (Oncorhynchus mykiss) and agastric common carp (Cyprinus carpio) assessed in vivo and in vitro. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 167: 58-64 (IF 2.5) [PubMed] [WebPage] [PDF]
Conference Proceeding
Schmid T, Günzel D, Bogdan M (2015) Automated quantification of the capacitance of epithelial cell layers from an impedance spectrum. BIOTECHNO 2015, p. 27-32 [PDF]
2014
Bücker R, Schulz E, Günzel D, Bojarski C, Lee IM, John LJ, Wiegand S, Janßen T, Wieler LH, Dobrindt U, Beutin L, Ewers C, Fromm M, Siegmund B, Troeger H, Schulzke JD (2014) α-Haemolysin of Escherichia coli: a potentiator of inflammatory activity in the colon. Gut 63(12): 1893-1901 (IF 14.7) [PubMed] [WebPage] [PDF] [Supplements]
Chai W, Zakrzewski SS, Günzel D, Pieper R, Wang Z, Twardziok Z, Janczyk P, Osterrieder N, Burwinkel M (2014) High-dose dietary zinc oxide mitigates infection with transmissible gastroenteritis virus in piglets. BMC Vet. Res. 10(1): 75 (
Georgi M, Rosendahl J, Ernst F, Günzel D, Aschenbach JR, Martens H, Stumpff F (2014) Epithelia of the ovine and bovine forestomach express basolateral maxi-anion channels permeable to the anions of short chain fatty acids. Pflügers Arch. 466(9):1689-712 (IF 4.1) [PubMed] [WebPage] [PDF]
Hering NA*, Richter JF* (*shared first authorship), Fromm A, Wieser A, Hartmann S, Günzel D, Bücker R, Fromm M, Schulzke JD° (°corresponding author), Troeger H (2014) TcpC protein from E. coli Nissle improves epithelial barrier function involving PKCζ and ERK1/2 signalling in HT-29/B6 cells. Mucosal Immunol. 7(2): 369-378 (°IF 7.4) [PubMed] [WebPage] [PDF]
Molenda N, Urbanova K, Weiser N, Kusche-Vihrog K, Günzel D, Schillers H (2014) Paracellular transport through healthy and cystic fibrosis bronchial epithelial cell lines – do we have a proper model? PLOS One 9(6): e100621 (IF 3.2) [PubMed] [WebPage] [PDF]
Richter JF, Pieper R, Zakrzewski SS, Günzel D, Schulzke JD, Van Kessel AG (2014) Diets high in fermentable protein and fiber alter tight junction protein composition with minor effect on barrier function in piglet colon. Br. J. Nutr. 111(6): 1040-1049 (IF 3.5) [PubMed] [WebPage] [PDF] [Supplements]
Rossa J, Plöger C, Vorreiter F, Saleh T, Protze J, Günzel D, Wolburg H, Krause G, Piontek J (2014) Claudin-3 and claudin-5 protein folding and assembly into the tight junction are controlled by non-conserved residues in transmembrane2 (TM3) and extracellular loop 2 (ECL2) segments. J. Biol. Chem. 289(11): 7641-7653 (IF 4.6) [29.01.14 Accepted] [PubMed] [WebPage] [PDF] [Supplements]
Rossa J*, Protze J* (*shared first authorship), Kern C, Piontek A, Günzel D, Krause G*, Piontek J* (*shared last authorship) (2014) Molecular and structural transmembrane determinants critical for embedding claudin-5 into tight junctions reveal distinct four helix bundle arrangement. Biochem. J. 464(1): 49-60 (IF 4.4) [PubMed] [WebPage] [PDF]
Whelan RA*, Rausch S* (*shared first authorship), Ebner F, Günzel D, Richter JF, Hering NA, Schulzke JD, Kühl AA, Keles A, Janczyk P, Nöckler K, Wieler LH, Hartmann S (2014) A transgenic probiotic secreting a parasite immunomodulator for site-directed treatment of gut inflammation. Mol. Ther. 22(10): 1730-1740 (IF 6.2) [PubMed] [WebPage] [PDF]
Reviews
Günzel D (2014) Impedanzspektroskopie in Physiologie und Pathophysiologie von Epitheliee. 17. Heiligenstädter Kolloquium "Technische Systeme für die Lebenswissenschaften", Bad Heiligenstadt, 22.-24.09.2014, Tagungsband p ###-###
Schmid T, Günzel D, Bogdan M (2014) Automated quantification of the relation between resistor-capacitor subcircuits from an impedance spectrum. Proc. Int. Conf. Bio-inspired Systems Signal Processing, p 141-148, DOI: 10.5220/0004746501410148
Schulzke JD, Siegmund B, Günzel D (2014) New insights in intestinal secretion. Gut 63: 1371-1372 (IF 14.7) (Commentary) [PubMed] [WebPage] [PDF]
2013
Schmid T, Bogdan M, Günzel D (2013) Discerning apical and basolateral properties of HT-29/B6 and IPEC-J2 cell layers by impedance spectroscopy, mathematical modeling and machine learning. PLOS One 8(7): e62913 (printed pages 1-12) (IF 3.5) [PubMed] [WebPage] [PDF] [Supplements, PDF]
Cording J, Berg J, Käding N, Bellmann C, Tscheik C, Westphal JK, Milatz S, Günzel D, Wolburg H, Piontek J, Huber O, Blasig IE (2013) In tight junctions, claudins regulate the interactions between occludin, tricellulin and marvelD3, which, inversely, modulate the claudin oligomerization. J. Cell Sci. 126(2): 554-564 (IF 5.3) [PubMed] [WebPage] [PDF] [Supplement]
Schmid T, Günzel D, Bogdan M (2013) Efficient prediction of x-axis intercepts of discrete impedance spectra. ESANN 2013 proceedings, ISBN 978-2-87419-081-0, p 185-190
Zakrzewski SS, Richter JF, Krug SM, Jebautzke B, Lee IM, Rieger J, Sachtleben M, Bondzio A, Schulzke JD, Fromm M, Günzel D (2013) Improved cell line IPEC-J2, characterized as a model for porcine jejunal epithelium. PLOS One 8(11): e79643 (print pages 1-12) (IF 3.7) [PubMed] [WebPage] [PDF] [Supplements]
Reviews
Günzel D, Yu AS (2013) Claudins and the modulation of tight junction permeability. Physiol. Rev. 93(2): 525-569 (IF 30.2) [PubMed] [WebPage] [PDF]
2012
Kirschner N, Rosenthal R, Günzel D, Moll I, Brandner JM (2012) Tight junctions and differentiation – a chicken or the egg question? Exp. Dermatol. 21(3): 171-175 (IF 3.6) [PubMed] [WebPage] [PDF]
Krug SM, Günzel D, Conrad MP, Rosenthal R, Fromm A, Amasheh S, Schulzke JD, Fromm M (2012) Claudin-17 forms tight junction channels with distinct anion selectivity. Cell. Mol. Life Sci. 69(16): 2765-2778
Rosenthal R*, Günzel D* (*shared first authorship), Finger C, Krug SM, Richter JF, Schulzke JD, Fromm M, Amasheh S (2012) The effect of chitosan on transcellular and paracellular mechanisms in the intestinal epithelial barrier. Biomaterials 33(9): 2791-2800 (IF 7.6) [PubMed] [WebPage] [PDF] [Supplement]
Schumann M, Günzel D, Buergel N, Richter JF, Troeger H, May C, Fromm A, Sorgenfrei D, Daum S, Bojarski C, Heyman M, Zeitz M, Fromm M, Schulzke JD (2012) Cell polarity-determining proteins Par-3 and PP-1 are involved in epithelial tight junction defects in celiac disease. Gut 61(2): 220-228 (IF 10.7) [PubMed] [WebPage] [PDF] [Supplements]
Handbook article
Günzel D, Fromm M (2012) Claudins and other tight junction proteins. Compreh. Physiol. (former Handbook of Physiology) 2(3): 1819-1852 (IF 0.8) [PubMed] [WebPage] [PDF]. Rank eight in most-cited articles of that journal in 2017. Present IF is 6.9
Reviews
Günzel D, Zakrzewski S, Schmid T, Pangalos M, Wiedenhoeft J, Blasse C, Ozboda C, Krug SM (2012) From TER to trans- and paracellular resistance: Lessons from impedance spectroscopy. Ann. N.Y. Acad. Sci. 1257: 142-151 (IF 4.4) [PubMed] [WebPage] [PDF]
Krug SM, Günzel D, Conrad MP, Lee IM, Amasheh S, Fromm M, Yu ASL (2012) Charge-selective claudin channels. Ann. N.Y. Acad. Sci. 1257: 20-28
Plöger S, Stumpff F, Penner GB, Schulzke JD, Gäbel G, Martens H, Shen Z, Günzel D, Aschenbach JR (2012) Microbial
butyrate and its role for barrier function in the gastrointestinal tract. Ann. N.Y. Acad. Sci. 1258: 52-59 (IF 4.4)
[PubMed] [WebPage]
[PDF] Schulzke JD, Günzel D, John
LJ, Fromm M (2012) Perspectives in tight junction research.
Ann. N.Y. Acad. Sci. 1257: 1-19
2011
Schulzke JD*, Andres S*, Amasheh M* (*shared first authorship), Fromm A, Günzel D (2011) Anti-diarrheal mechanism of the traditional remedy Uzara via reduction of active chloride secretion. PLoS One 6(3): e18107 (print pages 1-9) (IF 4.1) [PubMed] [WebPage] [PDF]
Stumpff F, Georgi MI, Mundhenk L, Rabbani I, Fromm M, Martens H, Günzel D (2011) Sheep rumen and omasum primary cultures and source epithelia: Barrier function aligns with expression of tight junction proteins. J. Exp. Biol. 214: 2871-2882 (IF 3.0) [PubMed] [WebPage] [PDF] [Supplement]
Nielsen HL, Nielsen H, Ejlertsen T, Engberg J, Günzel D, Zeitz M, Hering NA, Fromm M, Schulzke JD, Bücker R (2011) Oral and fecal Campylobacter concisus strains perturb barrier function by apoptosis induction in HT-29/B6 intestinal epithelial cells. Plos One 6(8): e23858 (print pages 1-8) (IF 4.1) [PubMed] [WebPage] [PDF]
Bücker R, Krug SM, Rosenthal R, Günzel D, Fromm A, Zeitz M, Chakraborty T, Fromm M, Epple HJ, Schulzke JD (2011) Aerolysin from Aeromonas hydrophila perturbs tight junction integrity and cell lesion repair in intestinal epithelial HT-29/B6 cells. J. Infect. Dis. 204 (8): 1283-1292 (IF 6.4) [PubMed] [WebPage] [PDF]
Hering NA, Richter JF, Krug SM, Günzel D, Fromm A, Bohn E, Rosenthal R, Bücker R, Fromm M, Troeger H, Schulzke JD (2011) Yersinia enterocolitica induces epithelial barrier dysfunction through regional tight junction changes in colonic HT-29/B6 cell monolayers. Lab. Invest. 91(2): 310-324 (IF 3.6) [PubMed] [WebPage] [PDF] [Supplement DOC]
Stuiver M, Lainez S, Will C, Terryn S, Günzel D, Debaix H, Sommer K, Kopplin K, Thumfart J, Kampik NB, Querfeld U, Willnow TE, Nemec V, Wagner C, Hoenderop JG, Devuyst O, Knoers NVAM, Bindels RJ, Meij IC*, Müller D* (*shared last authorship) (2011) CNNM2, encoding a basolateral protein required for renal Mg2+ handling, is mutated in dominant hypomagnesemia. Am. J. Hum. Genet. 88(3): 333-343
Review
Amasheh S, Fromm M, Günzel D (2011) Claudins of intestine and nephron - a correlation of molecular tight junction structure and barrier function. Acta Physiol. 201(1): 133-140 (IF 3.1) [PubMed] [WebPage] [PDF]
2010
Milatz S, Krug SM, Rosenthal R, Günzel D, Müller D, Schulzke JD, Amasheh S*, Fromm M* (*shared last authorship) (2010) Claudin-3 acts as a sealing component of the tight junction for ions of either charge and uncharged solutes. Biochim. Biophys. Acta Biomembr. 1798: 2048-2057 [PubMed] [WebPage] [PDF]]
Schmid T, Günzel D, Bogdan M (2010) Using an artificial neural network to determine electrical properties of epithelia. In: Diamantaras K, Duch W, Iliadis LS Eds., ICANN 2010, Part I, Lect. Notes Comput. Sci. 6352: 211-216 (DOI: 10.1007/978-3-642-15819-3_28) [WebPage] [PDF]
Rosenthal R, Milatz S, Krug SM,
Oelrich B, Schulzke JD, Amasheh S, Günzel D, Fromm M (2010) Claudin-2,
a component of the tight junction, forms a paracellular water channel.
J. Cell Sci. 123(11): 1913-1921 [PubMed]
[WebPage]
[PDF]
[Supplement]
Hillenbrand B, Günzel D, Richter JF, Höhne, Schreier E, Schulzke JD, Mankertz J (2010) Norovirus non-structural protein p20 leads to impaired restitution of epithelial defects by inhibition of actin cytoskeleton remodelling. Scand. J. Gastroent. 45(11): 1307-1319 [PubMed] [WebPage] [PDF]
Will C, Breiderhoff T, Thumfart J, Stuiver M, Kopplin K, Sommer K, Günzel D, Querfeld U, Meij IC, Shan Q, Bleich M, Willnow TE, Müller D (2010) Targeted deletion of murine Cldn16 identifies extra- and intrarenal compensatory mechanisms of Ca2+ and Mg2+ wasting. Am. J. Physiol. Renal Physiol. 298: F1152-F1161 [PubMed] [WebPage] [PDF]
Preston P, Wartosh L, Günzel D,
Fromm M, Kongsuphol P, Ousingsawat J, Kunzelmann K, Barhanin J, Warth R,
Jentsch TJ (2010) Disruption of the K+-channel
β-subunit KCNE3 reveals an important role in colonic and tracheal Cl-
transport. J. Biol. Chem. 285(10):
7165-7175 [PubMed] [PDF]
[Supplement] Review /
book chapter
Günzel D, Krug SM, Rosenthal R, Fromm M (2010) Biophysical methods to study tight junction permeability. Curr. Top. Membr. 65: 39-78 [Directory] [WebPage] [PDF]
2009
Günzel D, Amasheh S, Pfaffenbach S, Richter JF, Kausalya PJ, Hunziker W, Fromm M (2009b) Claudin-16 affects transcellular Cl- secretion in MDCK cells. J. Physiol. 587(15): 3777-3793 [PubMed] [WebPage] [PDF] [Supplement]
Günzel D, Stuiver M, Kausalya PJ, Haisch L, Krug SM, Rosenthal R, Meij IC, Hunziker W, Fromm M, Müller D (2009a) Claudin-10 exists in six alternatively spliced isoforms which exhibit distinct localization and function. J. Cell Sci. 122: 1507-1517 [PubMed] [WebPage] [PDF]
Krug SM, Fromm M, Günzel D (2009) Two-path impedance spectroscopy for measuring paracellular and transcellular epithelial resistance. Biophys. J. 97(8): 2202-2211 [PubMed] [WebPage] [PDF] [Supplement]
Krug SM, Amasheh S, Richter JF,
Milatz S, Günzel D, Westphal JK, Huber O, Schulzke JD, Fromm M (2009)
Tricellulin forms a barrier to macromolecules in tricellular tight junctions
without affecting ion permeability. Mol. Biol.
Cell 20: 3713-3724 [PubMed]
[WebPage]
[PDF] [Supplement
text] [Supplement
video]
Richter JF, Gitter AH, Günzel D, Weiss S, Mohamed W, Chakraborti T, Fromm M, Schulzke JD (2009) Listeriolysin O affects barrier function and induces chloride secretion in HT-29/B6 colon epithelial cells. Am. J. Physiol. Gastrointest. Liver Physiol. 296(6): G1350-G1359 [PubMed] [WebPage] [PDF]
Yu ASL, Cheng MH, Angelow S, Günzel D, Kanzawa SA, Schneeberger EE, Fromm M, Coalson RD (2009) Molecular basis for cation selectivity in claudin-2-based paracellular pores: Identification of an electrostatic interaction site. J. Gen. Physiol. 133(1): 111-127 [PubMed] [WebPage] [PDF]
Reviews
Fromm M, Krug SM, Zeissig S, Richter JF, Rosenthal R, Schulzke JD, Günzel D (2009) High resolution analysis of barrier function. Ann. N.Y. Acad. Sci. 1165: 74-81 [PubMed] [WebPage] [PDF]
Günzel D, Haisch L, Pfaffenbach S, Krug SM, Milatz S, Amasheh S, Hunziker W, Müller D (2009) Claudin function in the thick ascending limb of Henle's loop. Ann. N.Y. Acad. Sci. 1165: 152-162 [PubMed] [WebPage] [PDF]
Günzel D, Yu ASL (2009) Function and regulation of claudins in the thick ascending limb of Henle. Pflügers Arch. 458(1): 77-88 [PubMed] [WebPage] [PDF]
Amasheh S, Milatz S, Krug SM, Markov AG, Günzel D, Amasheh M, Fromm M (2009) Tight junction proteins as channel formers and barrier builders: claudin-2, -5, and -8. Ann. N.Y. Acad. Sci. 1165: 211-219 [PubMed] [WebPage] [PDF]
2007 - 2008
Gabriel TE, Günzel D (2007) Quantification of Mg2+ extrusion and cytosolic Mg2+-buffering in Xenopus oocytes. Arch. Biochem. Biophys. 458(1): 3-15 [PubMed] [WebPage] [PDF]
Troeger H*, Richter JF* (*shared first authorship), Beutin L, Günzel D, Dobrindt U, Epple HJ, Gitter AH, Zeitz M, Fromm M, Schulzke JD (2007) E. coli alpha-hemolysin induces focal leaks in colonic epithelium – a novel mechanism of bacterial translocation. Cell. Microbiol. 9(10): 2530-2540 [PubMed] [WebPage] [PDF]
Zeissig S, Bürgel N, Günzel D, Richter JF, Mankertz J, Wahnschaffe U, Kroesen AJ, Zeitz M, Fromm M, Schulzke JD (2007) Changes in expression and distribution of claudin-2, -5 and -8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease. Gut 56(1): 61-72 [PubMed] [WebPage] [PDF]
2006
Günzel D, Kucharski
LM, Kehres DG, Romero MF, Maguire ME (2006) The MgtC virulence factor of
Salmonella enterica serovar typhimurium activates Na+,K+-ATPase.
J. Bacteriol. 188(15): 5586-5594 [PubMed]
[WebPage] [PDF]
Günzel D*, Florian P* (*shared first authorship), Richter JF, Troeger H, Schulzke JD, Fromm M, Gitter AH (2006) Restitution of single-cell defects in the mouse colon epithelium differs from that of cultured cells. Am. J. Physiol. - Reg. Integ. Comp. Physiol. 290: R1496-R1507 [PubMed] [WebPage] [PDF] [Supplemental videos]
Reiter B, Kraft R, Günzel D, Zeissig S, Schulzke JD, Fromm M, Harteneck C (2006) TRPV4-mediated regulation of epithelial permeability. FASEB J. 20: 1802-1812 [PubMed] [WebPage] [PDF]
Kausalya PJ*, Amasheh S* (*shared
first authorship), Günzel D, Wurps H, Müller D, Fromm M, Hunziker W
(2006) Disease-associated mutations affect intracellular traffic and
paracellular Mg2+ transport function of claudin-16.
J. Clin. Invest. 116(4): 878-891 [PubMed]
[WebPage]
[PDF]
2005
Günzel D, Hintz K, Durry S, Schlue WR (2005) Mg2+-malate co-transport, a mechanism for Na+-independent Mg2+ transport in neurons of the leech Hirudo medicinalis. J. Neurophysiol. 94: 441-453 [PubMed] [WebPage] [PDF]
Günzel D, McGuigan JAS, Schlue WR (2005) Use of Mg2+ and Ca2+ macroelectrodes to measure binding in extracellular-like physiological solutions. Front. Biosci. 10: 905-918 [PubMed] [Full text] [Request text]
Tunggal JA*, Helfrich I* (*shared
first authorship), Schmitz A, Schwarz H, Günzel D, Fromm M, Kemler R,
Krieg T, Niessen CM (2005) E-cadherin is essential for in vivo epidermal
barrier function by regulating tight junctions.
EMBO J. 24: 1146-1156 [PubMed]
[WebPage] [PDF]
2001 - 2003
Günzel D, Schlue WR (2002) Determination of [Mg(2+)]i - an update on the use of Mg(2+)-selective electrodes. Biometals 15(3): 237-249 [PubMed] [Full text (produces an error at first attempt and sets a cookie, then click again)]
Günzel D, Zimmermann F, Durry S, Schlue WR (2001) Apparent intracellular Mg2+ buffering in neurons of the leech Hirudo medicinalis. Biophys. J. 80(3): 1298-1310 [PubMed] [Full text, WebPage] [Full text, PDF]
Müller A, Günzel D, Schlue WR (2003) Activation of AMPA/kainate receptors but not acetylcholine receptors causes Mg2+ influx into Retzius neurones of the leech Hirudo medicinalis. J. Gen. Physiol. 122: 727-739 [PubMed] [Full text, WebPage] [PDF]
McGuigan JAS, Elder HY, Günzel D, Schlue W-R (2002) Magnesium homeostasis in heart: a critical reappraisal. J. Clin. Basic Cardiol. 5: 5-22
Mooren FC, Turi S, Günzel D, Schlue WR, Domschke W, Singh J, Lerch MM (2001) Calcium-magnesium interactions in pancreatic acinar cells. FASEB J. 15(3): 659-672 [PubMed] [Full text, WebPage] [PDF]
1999 - 2000
Günzel D, Galler S (2000) Intracellular pH of crab and crayfish muscle fibre types during GABA application and inhibitory nerve stimulation. J. Comp. Physiol. [B] 170(7): 523-529 [PubMed] [PDF]
Günzel D, Schlue WR (2000) Mechanisms of Mg2+ influx, efflux and intracellular 'muffling' in leech neurones and glial cells. Magnes. Res. 13(2): 123-138. [PubMed]
Günzel D, Müller A, Durry S, Schlue WR (1999) Multi-barrelled ion-sensitive microelectrodes and their application in micro-droplets and biological systems. Electrochim. Acta 44: 3785-3793 [PDF]
Lüthi D, Günzel D, McGuigan JA (1999) Mg-ATP binding: its modification by spermine, the relevance to cytosolic Mg2+ buffering, changes in the intracellular ionized Mg2+ concentration and the estimation of Mg2+ by 31P-NMR. Exp. Physiol. 84(2): 231-252. [PubMed reference] [WebPage]
Hintz K, Günzel D, Schlue WR (1999) Na+-dependent regulation of the free Mg2+ concentration in neuropile glial cells and P neurones of the leech Hirudo medicinalis. Pflügers Arch. 437(3): 354-362 [PubMed] [PDF]
1991 - 1997
Günzel D, Durry S, Schlue WR (1997) Intracellular alkalinization causes Mg2+ release from intracellular binding sites in leech Retzius neurones. Pflügers Arch. 435(1): 65-73 [PubMed] [PDF]
Schlue W-R, Kilb W, Günzel D (1997) Ultramicroelectrodes for membrane research. Electrochim. Acta 42: 3197-3205 [PDF]
Günzel D, Schlue W-R (1997) Intracellular Mg2+ is regulated by 1 Na+/1 Mg2+ antiport in neurones of an invertebrate central nervous system. Electrochim. Acta 42: 3207-3215 [PDF]
Günzel D, Schlue WR (1996) Sodium-magnesium antiport in Retzius neurones of the leech Hirudo medicinalis. J. Physiol. 491(Pt 3): 595-608 [PubMed]
Günzel D, Rathmayer W (1994) Non-uniformity of sarcomere lengths can explain the 'catch-like' effect of arthropod muscle. J. Muscle Res. Cell Motil. 15(5): 535-546 [PubMed]
Günzel D, Galler S, Rathmayer W (1993) Fibre heterogeneity in the closer and opener muscles of crayfish walking legs. J. Exp. Biol. 175: 267-281 [PDF]
Günzel D, Galler S (1991) Intracellular free Mg2+ concentration in skeletal muscle fibres of frog and crayfish. Pflügers Arch. 417(5): 446-453 [PubMed]
