Publications: Susanne M. Krug

PubMed list of Susanne Krug,
listed papers: 76, h-index: 30
update 25.11.2022

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  • Sell T, Klotz C, Fischer MM, Astaburuaga-García R, Krug SM, Nitz M, Bu YJ, Drost J, Clevers H, Sers C, Morkel M, Blüthgen N (2023) Oncogenic signalling is coupled to colorectal cancer cell differentiation state. J. Cell Biol. ##: ###-### (accepted 07.03.2023. Preprint doi: ) (°IF 8.1)

    • Upcoming Editions

  • Krug SM, ed. (deadline Feb 28, 2023) "Solving the Puzzle: Molecular Research in Inflammatory Bowel Diseases" in Int. J. Mol. Sci. (°IF 6.2) Details

  • Fromm M, Krug SM, eds. (deadline Aug 31, 2023) "The Tight Junction and Its Proteins: From Structure to Pathologies" in Int. J. Mol. Sci. (°IF 6.2) Details


  • Weiß F, Czichos C, Knobe L, Voges L, Bojarski C, Michel G, Fromm M, Krug SM (2022) MarvelD3 is upregulated in ulcerative colitis and has attenuating effects during colitis indirectly stabilizing the intestinal barrier. Cells 11: 1551 (16 pages) doi: 10.3390/cells11091541 (°IF 7.7)

  • Weiß F, Holthaus D, Kraft M, Klotz C, Schneemann M, Schulzke JD, Krug SM (2022) Human duodenal organoid-derived monolayers serve as a suitable barrier model for duodenal tissue. Ann. NY Acad. Sci. 1515(1): 155-167, doi: 10.111/nyas.14804 (°IF 6.5)

  • Breiderhoff T*, Himmerkus N*  (*shared first authorship), Meoli L, Fromm A, Sewerin S, Kriuchkova N, Nagel O, Ladilov Y, Krug SM, Quintanova C, Stumpp M, Garbe-Schönberg  D, Westernströer U, Merkel C, Brinkhus MA, Altmüller J, Schweiger MR, Müller D, Mutig K, Morawski M, Halbritter J, Milatz S, Bleich M*, Günzel D* (*shared last authorship) (2022) Claudin-10a deficiency shifts proximal tubular Cl- permeability to cation selectivity via claudin-2 redistribution. J. Am. Soc. Nephrol. 33(4): 699-717, doi: 10.1681/ASN.2021030286  (°IF 15.0)

  • Haas AJ, Zihni C, Krug SM, Maraspini R, Otani T, Furuse M, Honigmann A, Balda MS*, Matter K* (*shared last authorship) (2022) Reciprocal regulation of cell mechanics and ZO-1 guides tight junction assembly and epithelial morphogenesis. Cells 11(23): 3775 (30 pages), doi: 10.3390/cells11233775 (°IF 7.7)

  • Hempel C*, Rosenthal R* (*shared first authorship), Fromm A, Krug SM, Fromm M, Günzel D, Piontek J (2022) Tight junction channels claudin-10b and claudin-15: Functional mapping of pore-lining residues. Ann. NY Acad. Sci. 1515(1): 129-142, doi: 10.1111/nyas.14794 (°IF 6.5)

  • Holthaus D*, Kraft MR* (*shared first authorship), Krug SM, Wolf S, Müller A, Delgado Betancourt E, Schorr M, Holland G, Knauf F, Schulzke JD, Aebischer T°, Klotz C° (°shared last authorship) (2022) Dissection of barrier dysfunction in organoid-derived human intestinal epithelia induced by Giardia duodenalis. Gastroenterology 162(3): 844-858, (°IF 33.9)

  • Reinhold AK, Krug SM, Salvador E, Sauer RS, Karl-Schöller F, Malcangio M, Sommer C, Rittner HL (2022) MicroRNA-21-5p functions via RECK/MMP9 as a proalgesic regulator of the blood nerve barrier in nerve injury. Ann. NY Acad. Sci. 1515(1): 184-195, doi: 10.1111/nyas.14816, TableS1, TableS2 (°IF 6.5)

  • Warschkau D, Delgado-Betancourt E, Holthaus D, Müller A, Kliem G, Krug SM, Schulzke JD, Aebischer T, Klotz C*, Seeber F* (*shared last authorship) (2022). From 3D to 2D: Harmonization of protocols for two-dimensional cultures on cell culture inserts of intestinal organoids from various species. Bio-protocol 12(2): e4295 (25 pages). doi: 10.21769/BioProtoc.4295


  • Hu JCE, Weiß F, Bojarski C, Branchi F, Schulzke JD, Fromm M, Krug SM (2021) Expression of tricellular tight junction proteins and the paracellular macromolecule barrier are recovered in remission of ulcerative colitis. BMC Gastroent. 21(1): 141, doi: 10.1186/s12876-021-01723-7 (IF 2.9)

  • Ayala-Torres C, Krug SM, Rosenthal R*, Fromm M* (*shared last authorship) (2021) Angulin-1 (LSR) affects paracellular water transport, however only in tight epithelial cells. Int. J. Mol. Sci. 22(15): 7827 (25 pages). doi: 10.3390/ijms22157827 (IF 6.2)

  • Chen JTC, Schmidt L, Schürger C, Hankier MK, Krug SM, Rittner HL (2021) Netrin-1 as a multitarget barrier stabilizer in the peripheral nerve after injury. Int. J. Mol. Sci. (SI: Novel mechanisms and drug molecules modulating chronic pain") (°IF 5.9) 22(18): 10090 (16 pages+Suppl)., Supplement (IF 6.2)

  • Delbue D, Lebenheim L, Cardoso-Silva D, Dony V, Krug SM, Richter JF, Manna S, Munoz M, Wolk K, Heldt C, Heimesaat M, Sabat R, Siegmund B, Schumann M (2021) Reprogramming intestinal epithelial cell polarity by interleukin-22. Front. Med. (Lausanne) 8: 656047. doi: 10.3389/fmed.2021.656047 (IF 5.1)

    • Review

  • Stürzl M, Kunz M, Krug SM, Naschberger E (2021) Angiocrine regulation of epithelial barrier integrity in inflammatory bowel disease. Front Med. (Lausanne) 8: 643607 (11 pages). doi: 10.3389/fmed.2021.643607 (IF 5.1)

    • Editorial

  • Weidinger C, Krug SM, Voskens C, Moschen AR, Atreya I (2021) Loss of epithelial barrier integrity in inflammatory diseases: cellular mediators and therapeutic targets. Front. Med. (Lausanne) 8: 813153 (3 pages). doi: 10.3389/fmed.2021.813153 (IF 5.1)



  • Ayala-Torres C, Krug SM, Schulzke JD, Rosenthal R*, Fromm M* (*shared last authorship) (2019) Tricellulin effect on paracellular water transport. Int. J. Mol. Sci. 20(22): 5700 (15 pages) [PubMed] [WebPage] [PDF] (IF 4.6)

  • Reinhold AK, Yang S, Chen JT, Hu L, Sauer RS, Krug SM, Mambretti E, Fromm M, Brack A, Rittner HL (2019) Tissue plasminogen activator and neuropathy open the blood-nerve barrier with upregulation of miR-155-5p in male rats. Biochim. Biophys. Acta - Mol. Basis Dis. 1865(6): 1160-1169 [PubMed] [WebPage]  (IF 4.5)

  • Uwada J, Yazawa T, Mikami D, Krug SM, Fromm M, Sada K, Muramatsu I, Taniguchi T (2019) Store-operated calcium entry (SOCE) contributes to phosphorylation of p38 MAPK and suppression of TNF-α signalling in the intestinal epithelial cells. Cell. Signalling 63: 109358 (10 pages) [PubMed] [WebPage] [PDF] [Supplement] (IF 4.0)

    • Review

  • Hashimoto Y, Tachibana K, Krug SM, Kunisawa J, Fromm M, Kondoh M (2019) Potential for tight junction protein-directed drug development using claudin binders and angubindin-1. Int. J. Mol. Sci. 20 (16): 4016 (17 pages) [PubMed] [WebPage] [PDF] (IF 4.6)


  • Krug SM, Bojarski C, Fromm A, Lee IM, Dames P, Richter JF, Turner JR, Fromm M*, Schulzke JD* (*shared last authorship) (2018) Tricellulin is regulated via interleukin-13-receptor α2, affects macromolecule uptake, and is decreased in ulcerative colitis. Mucosal Immunol. 11(2): 345-356 (IF 7.4) [PubMed] [WebPage] [PDF] [Supplement] [Supplementary Movie]

  • Blecharz-Lang KG, Prinz V, Burek M, Frey D, Schenkel T, Krug SM, Fromm M, Vajkoczy P (2018) Gelatinolytic activity of autocrine matrix metalloproteinase-9 leads to endothelial de-arrangement in Moyamoya disease. J. Cereb. Blood Flow Metab. 38(11): 1940-1953 (IF 6.0) [PubMed] [DOI] [PDF] [Supplement]

  • Bücker R, Krug SM, Moos V, Bojarski C, Schweiger MR, Kerick M, Fromm A, Janßen S, Fromm M, Hering NA, Siegmund B, Schneider T, Barmeyer C, Schulzke JD (2018) Campylobacter jejuni impairs sodium transport and epithelial barrier function via cytokine release in human colon. Mucosal Immunol. 11(2): 474-485 (IF 7.4) [PubMed] [DOI] [PDF] [Supplement1] [Supplement2]




  • Dames P, Bergann T, Fromm A, Bücker R, Barmeyer C, Krug SM, Fromm M, Schulzke JD (2015) Interleukin-13 affects the intestinal epithelial sodium channel (ENaC) by coordinated modulation of STAT6 and p38 MAPK activity. J. Physiol. (Lond.) 593(24): 5269-5282 (IF 4.7) [PubMed] [WebPage] [PDF]

  • Khan RI, Uwada J, Yazawa T, Islam T, Krug SM, Fromm M, Karaki S, Suzuki Y, Kuwahara A, Yoshiki H, Sada K, Muramatsu I, Anisuzzaman AS, Taniguchi T (2015) Activation of muscarinic cholinoceptor (mAChR) ameliorates tumor necrosis factor-α-induced barrier dysfunction by the regulation of nuclear factor-κB signaling pathway in intestinal epithelial cells. FEBS Lett. 589(23): 3640-3647 (IF 3.5) [PubMed] [WebPage] [PDF]


  • Sauer RS, Krug SM, Hackel D, Staat C, Konasin N, Yang S, Niedermirtl B, Bosten J, Günther R, Dabrowski S, Doppler K, Sommer C, Blasig IE, Brack A*, Rittner HL* (*shared last authorship) (2014) Safety, efficacy, and molecular mechanism of claudin-1-specific peptides to enhance blood-nerve-barrier permeability. J. Contr. Release 185: 88-98 (IF 7.7) [PubMed] [WebPage] [PDF] [Supplement]

  • Capaldo CT, Farkas AE, Hilgarth RS, Krug SM, Wolf MF, Benedik JK, Fromm M, Koval MH, Parkos CA, Nusrat A (2014) Proinflammatory cytokine-induced tight junction remodeling through dynamic self-assembly of claudins. Mol. Biol. Cell 25(18): 2710-2719 (IF 4.5) [PubMed] [WebPage] [PDF+Supplements]

  • Dittmann I, Amasheh M, Krug SM, Markov AG, Fromm M, Amasheh S (2014) Laurate permeabilizes the paracellular pathway for small molecules in the intestinal epithelial cell model HT-29/B6 via opening the tight junctions by reversible relocation of claudin-5. Pharm. Res. 31(9): 2539-2548 {Erratum correcting a misprint in the Title: Pharm. Res. 32(2): 737} (IF 3.4) [PubMed] [WebPage] [PDF]

    • Review

  • Krug SM, Schulzke JD, Fromm M (2014) Tight junction, selective permeability, and related diseases. Semin. Cell Devel. Biol. 36: 166-176 (IF 6.3) [PubMed] [WebPage] [PDF]


  • Krug SM, Amasheh M, Dittmann I, Christoffel I, Fromm M, Amasheh S (2013) Sodium caprate as an enhancer of macromolecule permeation across tricellular tight junctions of intestinal cells. Biomaterials 34(1): 275-282 (IF 8.3) [PubMed] [WebPage] [PDF]

  • Dörfel MJ, Westphal JK, Bellmann C, Krug SM, Cording J, Mittag S, Tauber R, Fromm M, Blasig IE, Huber O (2013) CK2-dependent phosphorylation of occludin regulates the interaction with ZO-proteins and tight junction integrity. Cell Commun. Signal. 11(1): 40 (IF 4.7) [PubMed] [WebPage] [PDF]

  • Zakrzewski SS, Richter JF, Krug SM, Jebautzke B, Lee IM, Rieger J, Sachtleben M, Bondzio A, Schulzke JD, Fromm M, Günzel D (2013) Improved cell line IPEC-J2, characterized as a model for porcine jejunal epithelium. PLOS One 8(11): e79643 (print pages 1-12) (IF 3.5) [PubMed] [WebPage] [PDF] [Supplements]


  • Krug SM, Günzel D, Conrad MP, Rosenthal R, Fromm A, Amasheh S, Schulzke JD, Fromm M (2012) Claudin-17 forms tight junction channels with distinct anion selectivity. Cell. Mol. Life Sci. 69(16): 2765-2778 (IF 5.6) [PubMed] [WebPage] [PDF] [Supplement]

  • Hackel D, Krug SM, Sauer RS, Mousa SA, Böcker A, Pflücke D, Wrede EJ, Kistner K, Hoffmann T, Niedermirtl B, Sommer C, Bloch L, Huber O, Blasig IE, Amasheh S, Reeh PW, Fromm M, Brack A, Rittner HL (2012) Transient opening of the perineurial barrier for analgesic drug delivery. Proc. Natl. Acad. Sci. USA 109(29): E2018-E2027 (IF 9.7) [PubMed] [WebPage] [PDF]

  • Rosenthal R*, Günzel D* (*shared first authorship), Finger C, Krug SM, Richter JF, Schulzke JD, Fromm M, Amasheh S (2012) The effect of chitosan on transcellular and paracellular mechanisms in the intestinal epithelial barrier. Biomaterials 33(9): 2791-2800 (IF 7.6) [PubMed] [WebPage] [PDF] [Supplement]

  • Shalapour S, Deiser K, Kühl AA, Glauben R, Krug SM, Fischer A, Sercan Ö, Chappaz S, Bereswill S, Heimesaat MM, Loddenkemper C, Fromm M, Finke D, Hämmerling GJ, Arnold B, Siegmund B, Schüler T (2012) Interleukin-7 links T lymphocyte and intestinal epithelial cell homeostasis. PLOS One 7(2): e31939 (print pages 1-11) (IF 3.7) [PubMed] [WebPage] [PDF]

  • Takahashi A*, Saito Y*, Kondoh M*°, Matsushita K, Krug SM, Suzuki H, Tsujino H, Li X, Aoyama H, Matsuhisa K, Uno T, Fromm M, Hamakubo T, Yagi K (2012) Creation and biochemical analysis of a broad-specific claudin binder. Biomaterials 33(12): 3464-3474 (IF 7.6) [PubMed] [WebPage] [PDF] (*shared first authorship, °corresponding author)

  • Veshnyakova A, Krug SM, Mueller SL, Piontek J, Protze J, Fromm M, Krause G (2012) Determinants contributing to claudin ion channel formation. Ann. N.Y. Acad. Sci. 1257: 45-53 (IF 4.4) [PubMed] [WebPage] [PDF] (Original paper)

    • Reviews

  • Krug SM, Günzel D, Conrad MP, Lee IM, Amasheh S, Fromm M, Yu ASL (2012) Charge-selective claudin channels. Ann. N.Y. Acad. Sci. 1257: 20-28 (IF 4.4) [PubMed] [WebPage] [PDF]

  • Günzel D, Zakrzewski S, Schmid T, Pangalos M, Wiedenhoeft J, Blasse C, Ozboda C, Krug SM (2012) From TER to trans- and paracellular resistance: Lessons from impedance spectroscopy. Ann. N.Y. Acad. Sci. 1257: 142-151 (IF 4.4) [PubMed] [WebPage] [PDF]


  • Bücker R, Krug SM, Rosenthal R, Günzel D, Fromm A, Zeitz M, Chakraborty T, Fromm M, Epple HJ, Schulzke JD (2011) Aerolysin from Aeromonas hydrophila perturbs tight junction integrity and cell lesion repair in intestinal epithelial HT-29/B6 cells. J. Infect. Dis. 204 (8): 1283-1292 (IF 6.4) [PubMed] [WebPage] [PDF]

  • Hering NA, Richter JF, Krug SM, Günzel D, Fromm A, Bohn E, Rosenthal R, Bücker R, Fromm M, Troeger H, Schulzke JD (2011) Yersinia enterocolitica induces epithelial barrier dysfunction through regional tight junction changes in colonic HT-29/B6 cell monolayers. Lab. Invest. 91(2): 310-324 (IF 3.6) [PubMed] [WebPage] [PDF] [Supplement]


  • Amasheh M, Fromm A, Krug SM, Amasheh S, Andres S, Zeitz M, Fromm M, Schulzke JD (2010) TNFa-induced and berberine-antagonized tight junction barrier impairment via tyrosine kinase, pAkt, and NFkB signaling. J. Cell Sci. 123(23): 4145-4155 (IF 6.3) [PubMed] [WebPage] [PDF] [Supplements]

  • Milatz S, Krug SM, Rosenthal R, Günzel D, Müller D, Schulzke JD, Amasheh S*, Fromm M* (*shared last authorship) (2010) Claudin-3 acts as a sealing component of the tight junction for ions of either charge and uncharged solutes. Biochim. Biophys. Acta Biomembr. 1798: 2048-2057 (IF 4.6) [PubMed] [WebPage] [PDF]

  • Rosenthal R, Milatz S, Krug SM, Oelrich B, Schulzke JD, Amasheh S, Günzel D, Fromm M (2010) Claudin-2, a component of the tight junction, forms a paracellular water channel. J. Cell Sci. 123(11): 1913-1921 (IF 6.3) [PubMed] [WebPage] [PDF] [Supplement]

  • Westphal JK, Dörfel MJ, Krug SM, Cording JD, Piontek J, Blasig IE, Tauber R, Fromm M, Huber O (2010) Tricellulin forms homomeric and heteromeric tight junctional complexes. Cell. Mol. Life Sci. 67(12): 2057-2068 (IF 7.0) [PubMed] [WebPage] [PDF] [Supplement]

    • Review / book chapter

  • Günzel D, Krug SM, Rosenthal R, Fromm M (2010) Biophysical methods to study tight junction permeability. Curr. Top. Membr. 65: 39-78 (IF 0.7) [Directory] [WebPage] [PDF]


  • Krug SM, Amasheh S, Richter JF, Milatz S, Günzel D, Westphal JK, Huber O, Schulzke JD, Fromm M (2009) Tricellulin forms a barrier to macromolecules in tricellular tight junctions without affecting ion permeability. Mol. Biol. Cell 20: 3713-3724 (IF 6.0) [PubMed] [WebPage] [PDF] [Supplement text] [Supplement video]

  • Krug SM, Fromm M, Günzel D (2009) Two-path impedance spectroscopy for measuring paracellular and transcellular epithelial resistance. Biophys. J. 97(8): 2202-2211 (IF 4.4) [PubMed] [WebPage] [PDF] [Supplement]

  • Amasheh S*, Milatz S* (*shared first authorship), Krug SM, Bergs M, Amasheh M, Schulzke JD, Fromm M (2009) Na+ absorption defends from paracellular back-leakage by claudin-8 upregulation. Biochem. Biophys. Res. Comm. 378(1): 45-50 (IF 2.5) [PubMed] [WebPage] [PDF]

  • Günzel D, Stuiver M, Kausalya PJ, Haisch L, Krug SM, Rosenthal R, Meij IC, Hunziker W, Fromm M, Müller D (2009) Claudin-10 exists in six alternatively spliced isoforms which exhibit distinct localization and function. J. Cell Sci. 122: 1507-1517 (IF 6.1) [PubMed] [WebPage] [PDF]

  • Mankertz J*, Amasheh M* (*shared first authorship), Krug SM, Fromm A, Amasheh S, Hillenbrand B, Tavalali S, Fromm M, Schulzke JD (2009) TNFalpha up-regulates claudin-2 expression in epithelial HT-29/B6 cells via phosphatidylinositol-3-kinase signaling. Cell Tiss. Res. 336(1): 67-77 (IF 2.3) [PubMed] [WebPage] [PDF]

  • Ziera T, Irlbacher H, Fromm A, Latouche C, Krug SM, Fromm M, Jaisser F, Borden SA (2009) Cnksr3 is a direct mineralocorticoid receptor target gene and plays a key role in the regulation of the epithelial sodium channel. FASEB J. 23(11): 3936-3946 (IF 6.4) [PubMed] [WebPage] [PDF]

    • Reviews

  • Amasheh S, Milatz S, Krug SM, Markov AG, Günzel D, Amasheh M, Fromm M (2009) Tight junction proteins as channel formers and barrier builders: claudin-2, -5, and -8. Ann. N.Y. Acad. Sci. 1165: 211-219 (IF 2.7) [PubMed] [WebPage] [PDF]

  • Fromm M, Krug SM, Zeissig S, Richter JF, Rosenthal R, Schulzke JD, Günzel D (2009) High resolution analysis of barrier function. Ann. N.Y. Acad. Sci. 1165: 74-81 (IF 2.7) [PubMed] [WebPage] [PDF]

  • Günzel D, Haisch L, Pfaffenbach S, Krug SM, Milatz S, Amasheh S, Hunziker W, Müller D (2009) Claudin function in the thick ascending limb of Henle's loop. Ann. N.Y. Acad. Sci. 1165: 152-162 (IF 2.7) [PubMed] [WebPage] [PDF]


  • Krug SM (2016) Tight Junction-Proteine als regulierbare Kanal- und Barrierebildner. Habilitation thesis, Experimental biomedicine, Charité - Universitätsmedizin Berlin

  • Krug SM (2009) Tricellulin und seine Funktion in der trizellulären Tight Junction von Epithelzellen. Doctoral thesis, Biochemistry, Freie Universität Berlin

  • Krug SM (2006) Transfektion von MDCK-Zellen mit Claudin-12-cDNA und Analyse der differenzierungsabhängigen Expression von Tight Junction-Proteinen. Diploma thesis, Biochemistry, Freie Universität Berlin