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Publications: Susanne M. Krug
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2025
Krug SM*, Lee IM*, Knobe L* (*shared first authorship), Atalla MS, Rittner HL, Fromm M (2025) Characterization of the epi-perineurial barrier function using a novel Ussing chamber-based approach. Acta Biomater. (online pre-proof) doi: 10.1016/j.actbio.2025.04.043 (°IF 9.4)
Martínez-Perafán F, Fromm A, van der Veen RE, Waldow A, Lehmann M, Krug SM, Günzel D, Rosenthal R, Fromm M, Piontek J (2025) Effect of claudin-1 or -3 expression on cation and water channel properties of claudin-2.
Bao LL, Yu YQ, González-Acera M, Patankar JV, Giessl A, Sturm G, Kühl AA, Atreya R, Erkert L, Gámez-Belmonte R, Krug SM, Schmid B, Tripal P, Chiriac M, Hildner K, Siegmund B, Wirtz S, Stürzl M, Abdou MM, Trajanoski Z, The TRR241 IBDome Consortium, Neurath MF, Zorzano A, Becker C (2025) Epithelial OPA1 links mitochondrial fusion to inflammatory bowel disease. Science Transl. Med.
17: eadn8699 (15 pages). doi: 10.1126/scitranslmed.adn8699 (°IF 15.8)Hartmannsberger B, Ben-Kraiem A, Kramer S, Guidolin C, Kazerani I, Doppler K, Thomas D, Gurke R, Sisignano M, Kalelkar PP, García AJ, Monje PV, Sammeth M, Nusrat A, Brack A, Krug SM, Sommer C, Rittner HL (2025) TAM receptors mediate the Fpr2-driven pain resolution and fibrinolysis after nerve injury. Acta Neuropathol. 149(1): 1 (21 pages). doi: 10.1007/s00401-024-02840-9 (°IF 9.3)
Marinovic I, Bartosova M, Levai E, Herzog R, Saleem A, Du Z, Zhang C, Sacnun JM, Pitaraki E, Sinis S,
Damgov I, Krunic D, Lajqi T, Al-Saeedi M, Szabo JA, Hausmann M, Domonkos P, Kratochwill K, Krug SM, Zarogiannis SG, Schmitt CP (2025) Molecular and functional characterization of the
peritoneal mesothelium, a barrier for solute transport. Function
6(1): zqae051 (12 pages), doi:
10.1093/function/zqae051 (°IF 5.1)
Review
Liebing E*, Krug SM* (*shared first authorship), Neurath MF, Siegmund B, Becker C (2025) Wall of resilience: How the intestinal epithelium prevents inflammatory onslaught in the gut. Cell. Mol. Gastroenterol. Hepatol. 19)2): 101423 (17 pages) doi:10.1016/j.jcmgh.2024.101423 (°IF 7.1)
Consortial collaborations
(*with Krug SM),
(*with Krug SM) (2025) TIFA renders intestinal epithelial cells responsive to microbial ADP-heptose and drives colonic inflammation in mice.
Forster PM, Jakob MO, Yusuf D, Bubeck M, Limberger H, Luo Y, Thieme P, Polici A, Sterczyk N, Boulekou S, Bartel L, Cosovanu C, Witkowski M, González-Acera M, Kühl AA, Weidinger C; TRR241 IBDome Consortium* (*with Krug SM); Backofen R, Hegazy AN, Patankar JV, Klose CSN (2025) A transcriptional atlas of gut-innervating neurons reveals activation of interferon signaling and ferroptosis during intestinal inflammation.
Horn V, Cancino CA, Steinheuer LM, Obermayer B, Fritz K, Nguyen AL, Juhran KS, Plattner C, Bösel D, Oldenburg L, Burns M, Schulz AR, Saliutina M, Mantzivi E, Lissner D, Conrad T, Mashreghi MF, Zundler S, Sonnenberg E, Schumann M, Haag LM, Beule D, Flatz L, TRR241 IBDome Consortium* (*with Krug SM), Trajanoski Z, D'Haens G, Weidinger C, Mei HE, Siegmund B, Thurley K, Hegazy AN (2025) Multimodal Profiling of Peripheral Blood Identifies Proliferating Circulating Effector CD4+ T Cells as Predictors for Response to Integrin α4β7-Blocking Therapy in Inflammatory Bowel Disease. Gastroenterology 168(2): 327-343. doi: 10.1053/j.gastro.2024.09.021 (°IF 25.7)
2024
Pfeffer T*, Krug SM* (*shared first authorship), Kracke T, Schürfeld R, Colbatzky F, Kirschner P, Medert R, Freichel M, Schumacher D, Bartosova M, Zarogiannis SG, Muckenthaler MU, Altamura S, Pezer S, Volk N, Schwab C, Duensing S, Fleming T, Heidenreich E, Zschocke J, Hell R, Poschet G, Schmitt CP°, Peters V° (°shared last authorship) (2024) Knock-out of dipeptidase CN2 in human proximal tubular cells disrupts dipeptide and amino acid homeostasis and para- and transcellular solute transport. Acta Physiol. 240(4): e14126 (20 pages), doi: 10.1111/apha.14126 (°IF 5.6)
Voges L, Weiß F, Branco AT, Fromm M,
Krug SM (2024) Expression and localization profiles of tight junction proteins in immune cells depend on their activation status.
Int. J. Mol. Sci.
25(9): 4861 (18 pages), doi: 10.3390/ijms25094861
(°IF 4.9) Editorial
Krug SM, Fromm M (2024) Special Issue on "The tight junction and its proteins: From structure to pathologies". Int. J. Mol. Sci. 25(23): 13154 (3 pages), doi: 10.3390/ijms252313154 (°IF 4.9)
Editions
Krug SM, ed. (2024) Solving the puzzle: Molecular research in inflammatory bowel diseases, 2nd edition. Special Issue of the Int. J. Mol. Sci. (°IF 4.9) Collection of papers
Fromm M, Krug SM, eds. (2024) The tight junction and its proteins: From structure to pathologies. Special Issue of the Int. J. Mol. Sci. (15 articles) (°IF 4.9) Collection of papers
Consortial collaborations
Erkert L, Gamez-Belmonte R, Kabisch M, Schödel L, Patankar JV, Gonzalez-Acera M, Mahapatro M, Bao LL, Plattner C, Kühl AA, Shen J, Serneels L, De Strooper B; TRR241 IBDome Consortium* (*with Krug SM); Neurath MF, Wirtz S, Becker C (2024) Alzheimer's disease-related presenilins are key to intestinal epithelial cell function and gut immune homoeostasis. Gut 73(10): 1618-1631. doi: 10.1136/gutjnl-2023-331622 (°IF 23.0)
Horn V, Cancino CA, Steinheuer LM, Obermayer B, Fritz K, Nguyen AL, Juhran KS, Plattner C, Bösel D, Oldenburg L, Burns M, Schulz AR, Saliutina M, Mantzivi E, Lissner D, Conrad T, Mashreghi MF, Zundler S, Sonnenberg E, Schumann M, Haag LM, Beule D, Flatz L, TRR241 IBDome Consortium* (*with Krug SM), Trjanoski Z, D'Haens G, Weidinger C, Mei HE, Siegmund B, Thurley K, Hegazy AN (2024) Multimodal profiling of peripheral blood identifies proliferating circulating effector CD4+ T cells as predictors for response to integrin α4β7-blocking therapy in inflammatory bowel disease.
Lehmann M, Weixler B, Elezkurtaj S, Loddenkemper C, TRR241 IBDome Consortium* (*with Krug SM), Kühl AA, Siegmund B (2024) Spatial Single Cell Profiling Using Imaging Mass Cytometry: Inflammatory Versus Penetrating Crohn's Disease.
Schulz-Kuhnt A, Rühle K, Javidmehr A, Döbrönti M, Biwank J, Knittel S, Neidlinger P, Leupold J, Liu LJ, Dedden M, Taudte RV, Gessner A, Fromm MF, Mielenz D, Kreiss L, Waldner MJ, Schürmann S, Friedrich O, Dietel B, López-Posadas R, Plattner C, TRR241 IBDome Consortium* (*with Krug SM), Zundler S, Becker C, Atreya R, Neurath MF, Atreya I (2024) ATP citrate lyase (ACLY)-dependent immunometabolism in mucosal T cells drives experimental colitis in vivo. Gut 73(4): 601-612. doi: 10.1136/gutjnl-2023-330543 (°IF 23.0)
2023
Krug SM, Grünhagen C, Allers K, Bojarski C, Seybold J, Schneider T, Schulzke JD, Epple HJ (2023) Macromolecule translocation across the intestinal mucosa of HIV-infected patients by transcytosis and through apoptotic leaks. Cells 12(14): 1887 (13 pages). doi: 10.3390/cells12141887 (IF 5.1)
Chen JT*, Hu X* (*shared first authorship), Otto IUC, Schürger C, Rogalla von Bieberstein B, Doppler K, Krug SM, Hankir MK, Blasig R, Sommer C, Brack A, Blasig IE, Rittner HL (2023) Myelin barrier breakdown, mechanical hypersensitivity, and painfulness in polyneuropathy with claudin-12 deficiency.
Schneemann M, Heils L, Moos V, Weiß F, Krug SM, Weiner J, Beule D, Gerhard R, Schulzke JD, Bücker R (2023) A colonic organoid model challenged with the large toxins of Clostridioides difficile TcdA and TcdB exhibit deregulated tight junction proteins. Toxins 15: 643 (19 pages). doi: 10.3390/toxins15110643 (IF 3.9)
Sell T, Klotz C, Fischer MM, Astaburuaga-García R, Krug S, Drost J, Clevers H, Sers C, Morkel M, Blüthgen N (2023) Oncogenic signalling is coupled to colorectal cancer cell differentiation state. J. Cell Biol. 222(6): e202204001 (21 pages), doi: 10.1083/jcb.202204001 (IF 7.4)
Wittner L, Wagener L, Wiese JJ, Stolzer I, Krug SM, Naschberger E, Jackstadt R, Beyaert R, Atreya R, Kühl AA, Sturm G, Gonzalez-Acera M, Patankar JV, Becker C,
Siegmund B, Trajanoski Z, Winner B, Neurath MF, Schumann M, Günther C (2023) Proteolytic activity of the paracaspase MALT1 Is involved in epithelial restitution and mucosal healing.
Int. J. Mol. Sci. 24(8): 7402 (21 pages),
doi: 10.3390/ijms24087402
(IF 4.9) Review Krug SM (2023) Von 3D zu 2D: Intestinale Organoid-basierte Monolayer als
Modell der Darmbarriere.
BIOspektrum 29(7): 745-748. doi:
10.1007/s12268-023-2040-6 Editorial Krug SM (2023) Solving the puzzle: Molecular research in inflammatory bowel diseases.
Int. J. Mol. Sci. 24(17): 13389 (4 pages, Editorial article).
doi: org/10.3390/ijms241713389
(IF 4.9)
Edition
Krug SM, ed. (2023) Solving the puzzle: Molecular research in inflammatory bowel diseases. Special Issue of the Int. J. Mol. Sci. (12 articles) (IF 4.9), Collection of papers, doi: 10.3390/books978-3-0365-9863-5
2022
Weiß F, Czichos C, Knobe L, Voges L, Bojarski C, Michel G, Fromm M, Krug SM (2022) MarvelD3 is upregulated in ulcerative colitis and has attenuating effects during colitis indirectly stabilizing the intestinal barrier. Cells 11: 1551 (16 pages) doi: 10.3390/cells11091541 (IF 6.0)
Weiß F, Holthaus D, Kraft M, Klotz C, Schneemann M, Schulzke JD, Krug SM (2022) Human duodenal organoid-derived monolayers serve as a suitable barrier model for duodenal tissue. Ann. NY Acad. Sci. 1515(1): 155-167, doi: 10.111/nyas.14804 (IF 5.2)
Breiderhoff T*, Himmerkus N* (*shared first authorship), Meoli L, Fromm A, Sewerin S, Kriuchkova N, Nagel O, Ladilov Y, Krug SM, Quintanova C, Stumpp M, Garbe-Schönberg D, Westernströer U, Merkel C, Brinkhus MA, Altmüller J, Schweiger MR, Müller D, Mutig K, Morawski M, Halbritter J, Milatz S, Bleich M*, Günzel D* (*shared last authorship) (2022) Claudin-10a deficiency shifts proximal tubular Cl- permeability to cation selectivity via claudin-2 redistribution. J. Am. Soc. Nephrol. 33(4): 699-717, doi: 10.1681/ASN.2021030286 (IF 13.6)
Haas AJ, Zihni C, Krug SM, Maraspini R, Otani T, Furuse M, Honigmann A, Balda MS*, Matter K* (*shared last authorship) (2022) Reciprocal regulation of cell mechanics and ZO-1 guides tight junction assembly and epithelial morphogenesis. Cells 11(23): 3775 (30 pages), doi: 10.3390/cells11233775 (IF 6.0)
Hempel C*, Rosenthal R* (*shared first authorship), Fromm A, Krug SM, Fromm M, Günzel D, Piontek J (2022) Tight junction channels claudin-10b and claudin-15: Functional mapping of pore-lining residues. Ann. NY Acad. Sci. 1515(1): 129-142, doi: 10.1111/nyas.14794 (IF 5.2)
Holthaus D*, Kraft MR* (*shared first authorship), Krug SM, Wolf S, Müller A, Delgado Betancourt E, Schorr M, Holland G, Knauf F, Schulzke JD, Aebischer T°, Klotz C° (°shared last authorship) (2022) Dissection of barrier dysfunction in organoid-derived human intestinal epithelia induced by Giardia duodenalis. Gastroenterology 162(3): 844-858, doi.org/10.1053/j.gastro.2021.11.022 (IF 29.4)
Reinhold AK, Krug SM, Salvador E, Sauer RS, Karl-Schöller F, Malcangio M, Sommer C, Rittner HL (2022) MicroRNA-21-5p functions via RECK/MMP9 as a proalgesic regulator of the blood nerve barrier in nerve injury. Ann. NY Acad. Sci. 1515(1): 184-195, doi: 10.1111/nyas.14816, TableS1, TableS2 (IF 5.2)
Warschkau D, Delgado-Betancourt E, Holthaus D, Müller A, Kliem G, Krug SM, Schulzke JD, Aebischer T, Klotz C*, Seeber F* (*shared last authorship) (2022). From 3D to 2D: Harmonization of protocols for two-dimensional cultures on cell culture inserts of intestinal organoids from various species. Bio-protocol 12(2): e4295 (25 pages). doi: 10.21769/BioProtoc.4295
2021
Hu JCE, Weiß F, Bojarski C, Branchi F, Schulzke JD, Fromm M, Krug SM (2021) Expression of tricellular tight junction proteins and the paracellular macromolecule barrier are recovered in remission of ulcerative colitis. BMC Gastroent. 21(1): 141, doi: 10.1186/s12876-021-01723-7 (IF 2.9)
Ayala-Torres C, Krug SM, Rosenthal R*, Fromm M* (*shared last authorship) (2021) Angulin-1 (LSR) affects paracellular water transport, however only in tight epithelial cells. Int. J. Mol. Sci. 22(15): 7827 (25 pages). doi: 10.3390/ijms22157827 (IF 6.2)
Chen JTC, Schmidt L, Schürger C, Hankier MK, Krug SM, Rittner HL (2021) Netrin-1 as a multitarget barrier stabilizer in the peripheral nerve after injury. Int. J. Mol. Sci. (SI: Novel mechanisms and drug molecules modulating chronic pain") (°IF 5.9) 22(18): 10090 (16 pages+Suppl). doi.org/10.3390/ijms221810090, Supplement (IF 6.2)
Delbue D, Lebenheim L, Cardoso-Silva D, Dony V, Krug SM, Richter JF, Manna S, Munoz M, Wolk K, Heldt C, Heimesaat M, Sabat R, Siegmund B, Schumann M (2021) Reprogramming intestinal epithelial cell polarity by interleukin-22. Front. Med. (Lausanne)doi: 10.3389/fmed.2021.656047 (IF 5.1)
Review
Angiocrine regulation of epithelial barrier integrity in inflammatory bowel disease (IF 5.1)
Editorial
Weidinger C, Krug SM, Voskens C, Moschen AR, Atreya I (2021) Loss of epithelial barrier integrity in inflammatory diseases: cellular mediators and therapeutic targets. 8: 813153. doi: 10.3389/fmed.2021.813153 (IF 5.1)
2020
Hu JCH, Bojarski C, Branchi F, Fromm M, Krug SM (2020) Leptin downregulates angulin-1 in active Crohn's disease via STAT3. Int. J. Mol. Sci. 21(21): 7824 (17 pages) [PubMed] [WebPage] [PDF] [Supplement] (IF 5.9)
Kjærgaard S, Damm MMB, Chang J, Riis LB, Rasmussen HB, Hytting-Andreasen R, Krug SM, Schulzke JD, Bindslev N, Berner-Hansen M (2020) Altered structural expression and enzymatic activity parameters in quiescent ulcerative colitis: Are these potential normalization criteria? Int. J. Mol. Sci. 21(5): e1887 (18 pages) [PubMed] [WebPage] [PDF] (IF 5.9)
Rosenthal R, Günzel D, Piontek J, Krug SM, Ayala-Torres C, Hempel C, Theune D, Fromm M (2020) Claudin-15 forms a water channel through the tight junction with distinct function compared to claudin-2. Acta Physiol. 228(1): e13334 (15 pages) [PubMed] [WebPage] [PDF] (IF 6.3)
(Editorial Commentary on this article: Alexander RT (2020) Claudin-15 is not a drag! Acta Physiol. 228(1): e13397 [PubMed] [WebPage] [PDF])
Review
Piontek J, Krug SM, Protze J, Krause G, Fromm M (2020) Molecular architecture and assembly of the tight junction backbone. BBA - Biomembranes 1862(7): 183279 (15 pages) [Part of Special Volume "The vertebrate epithelial apical junctional complex", Hervé JC ed.] [PubMed] [WebPage] [PDF] [Supplement] (IF 3.7)
Editorial
Krug SM, Fromm M (2020) Special issue on "The tight junction and its proteins – more than just a barrier". Int. J. Mol. Sci. 21(13): 4612 (10 pages, Editorial article) doi: 10.3390/ijms21134612 (IF 5.9)
Edition
Fromm M, Krug SM, eds. (2020) The tight junction and Its proteins: More than just a barrier, Volume 1. Special Issue of the Int. J. Mol. Sci. (414 pages): doi: 10.3390/books978-3-03943-224-0, PDF, collection of papers (IF 5.9)
Fromm M, Krug SM, eds. (2020) The tight junction and Its proteins: More than just a barrier, Volume 2. Special Issue of the Int. J. Mol. Sci. (432 pages): doi:10.3390/books978-3-03943-301-8, PDF, collection of papers (IF 5.9)
2019
Ayala-Torres C, Krug SM, Schulzke JD, Rosenthal R*, Fromm M* (*shared last authorship) (2019) Tricellulin effect on paracellular water transport. Int. J. Mol. Sci. 20(22): 5700 (15 pages) [PubMed] [WebPage] [PDF] (IF 4.6)
Reinhold AK, Yang S, Chen JT, Hu L, Sauer RS, Krug SM, Mambretti E, Fromm M, Brack A, Rittner HL (2019) Tissue plasminogen activator and neuropathy open the blood-nerve barrier with upregulation of miR-155-5p in male rats. Biochim. Biophys. Acta - Mol. Basis Dis. 1865(6): 1160-1169 [PubMed] [WebPage] (IF 4.5)
Uwada J, Yazawa T, Mikami D, Krug SM, Fromm M, Sada K, Muramatsu I, Taniguchi T (2019) Store-operated calcium entry (SOCE) contributes to phosphorylation of p38 MAPK and suppression of TNF-α signalling in the intestinal epithelial cells. Cell. Signalling 63: 109358 (10 pages) [PubMed] [WebPage] [PDF] [Supplement] (IF 4.0)
Review
Hashimoto Y, Tachibana K, Krug SM, Kunisawa J, Fromm M, Kondoh M (2019) Potential for tight junction protein-directed drug development using claudin binders and angubindin-1. Int. J. Mol. Sci. 20 (16): 4016 (17 pages) [PubMed] [WebPage] [PDF] (IF 4.6)
2018
Krug SM, Bojarski C, Fromm A, Lee IM, Dames P, Richter JF, Turner JR, Fromm M*, Schulzke JD* (*shared last authorship) (2018) Tricellulin is regulated via interleukin-13-receptor α2, affects macromolecule uptake, and is decreased in ulcerative colitis. Mucosal Immunol. 11(2): 345-356 (IF 7.4) [PubMed] [WebPage] [PDF] [Supplement] [Supplementary Movie]
Blecharz-Lang KG, Prinz V, Burek M, Frey D, Schenkel T, Krug SM, Fromm M, Vajkoczy P (2018) Gelatinolytic activity of autocrine matrix metalloproteinase-9 leads to endothelial de-arrangement in Moyamoya disease. J. Cereb. Blood Flow Metab.
Bücker R, Krug SM, Moos V, Bojarski C, Schweiger MR, Kerick M, Fromm A, Janßen S, Fromm M, Hering NA, Siegmund B, Schneider T, Barmeyer C, Schulzke JD (2018) Campylobacter jejuni impairs sodium transport and epithelial barrier function via cytokine release in human colon. Mucosal Immunol. 11(2): 474-485 (IF 7.4) [PubMed] [DOI] [PDF] [Supplement1] [Supplement2]
2017
Krug SM (2017) Contribution of the tricellular tight junction to paracellular permeability in leaky and tight epithelia. Ann. N.Y. Acad. Sci. 1397: 219-230 (IF 4.3) [PubMed] [WebPage] [PDF]
Krug SM, Hayaishi T, Iguchi D, Watari A, Takahashi A, Fromm M, Nagahama M, Takeda H, Okada Y, Sawasaki T, Doi T, Yagi K, Kondoh M (2017) Angubindin-1, a novel paracellular absorption enhancer acting at the tricellular tight junction. J. Contr. Release 260: 1-11 (IF 7.9) [PubMed] [WebPage] [PDF] [Supplement]
Schütz A, Radusheva V, Krug SM*, Heinemann U* (*shared last authorship) (2017) Crystal structure of the tricellulin C-terminal coiled-coil domain reveals a unique mode of dimerization. Ann. N.Y. Acad. Sci. 1405: 147-159 (IF 4.3) [PubMed] [WebPage] [PDF] [Supplement]
Blecharz KG*, Frey D* (*shared first authorship), Schenkel T, Prinz V, Bedini G, Krug SM, Czabanka M, Wagner J, Fromm M, Bersano A, Vajkoczy P (2017) Autocrine release of angiopoietin-2 mediates cerebrovascular disintegration in Moyamoya disease. J. Cereb. Blood Flow Metab. 37(4): 1527-1539 (IF 6.0) [PubMed] [WebPage] [PDF] [Supplement]
Bücker R,
Krug SM, Fromm A, Nielsen HL, Fromm M, Nielsen H, Schulzke JD (2017) Campylobacter fetus
impairs barrier function in HT-29/B6 cells through focal tight junction alterations and leaks.
Cording J*, Arslan B* (*shared first authorship), Staat C, Dithmer S, Krug SM, Krüger A, Berndt P, Günther R, Winkler L, Blasig IE, Haseloff RF (2017) Trictide, a tricellulin-derived peptide to overcome cellular barriers. Ann. N.Y. Acad. Sci. 1405: 89-101 (IF 4.3)
[PubMed] [WebPage] [PDF]Epple HJ*, Friebel J*, Moos V* (*shared first authorship), Troeger H, Krug SM, Allers K, Schinnerling K, Fromm A, Siegmund B, Fromm M, Schulzke JD°, Schneider T° (°shared last authorship) (2017) Architectural and fuctional alterations of the small intestinal mucosa in classical Whipple's disease. Mucosal Immunol. 10(6): 1542-1552 (IF 7.4)
Hering NA, Luettig J, Krug SM, Wiegand S, Gross G, van Tol EA, Schulzke JD*, Rosenthal R* (*shared last authorship) (2017) Lactoferrin protects against intestinal inflammation or bacteria-induced barrier dysfunction in vitro. Ann. N.Y. Acad. Sci. 1405: 177-188 (IF 4.3) [PubMed] [WebPage] [PDF]
Rosenthal R, Günzel D,
Krug SM, Schulzke JD, Fromm M, Yu ASL (2017) Claudin-2-mediated
cation and water transport share a common pore.
Acta Physiol.
219(2): 521-536
(IF 5.9)
[PubMed]
[WebPage]
[PDF]
Rosenthal R, Luettig J, Hering NA, Krug SM, Albrecht U, Fromm M, Schulzke JD (2017) Myrrh exerts barrier-stabilizing and -protective effects in HT-29/B6 and Caco-2 intestinal epithelial cells. Int. J. Colorectal Dis. 32(5): 623-634 (IF 2.5) [PubMed] [WebPage] [PDF]
Uwada J, Yazawa T, Islam MT, Khan MRI, Krug SM, Fromm M, Karaki SI, Suzuki Y, Kuwahara A, Yoshiki H, Sada K, Muramatsu I, Taniguchi T (2017) Activation of muscarinic receptors prevents TNF-α-mediated intestinal epithelial barrier disruption through p38 MAPK. Cell. Signal. 35: 188-196 (IF 3.5) [PubMed] [WebPage] [PDF]
Review
Fromm M, Piontek J, Rosenthal R, Günzel D, Krug SM (2017) Tight junctions of the proximal tubule and their channel proteins. Pflügers Arch. 469(7-8): 877-887 (IF 2.8) [PubMed] [WebPage] [PDF]
Martini E, Krug SM, Siegmund B, Neurath MF, Becker C (2017) Mend your fences: The epithelial barrier and its relationship with mucosal immunity in inflammatory bowel disease. Cell. Mol. Gastroent. Hepatol. 4(1): 33-46 (new journal, no IF yet) [PubMed] [WebPage] [PDF]
2016
Conrad MP*, Piontek J* (*shared first authorship), Günzel D, Fromm M, Krug SM (2016) Molecular basis of claudin-17 anion selectivity. Cell. Mol. Life Sci. 73(1): 185-200 (IF 5.9) [PubMed] [WebPage] [PDF] [Supplement]
Demehri FR*, Krug SM* (*shared first authorship), Feng Y, Lee IM, Schulzke JD, Teitelbaum DH (2016) Tight junction ultrastructure alterations in a mouse model of enteral nutrient deprivation. Dig. Dis. Sci. 61(6): 1524-1533 (IF 2.9) [PubMed] [WebPage] [PDF]
Yang S*, Krug SM* (*shared first authorship), Heitmann J, Hu L, Reinhold AK, Sauer S, Bosten J, Sommer C, Fromm M, Brack A*, Rittner HL* (*shared last authorship) (2016) Analgesic drug delivery via recombinant tissue plasminogen activator and mRNA-183-triggered opening of the blood-nerve barrier. Biomaterials 82: 20-33 (IF 8.4) [PubMed] [WebPage] [PDF] [Supplement]
Luettig J, Rosenthal R, Lee IM, Krug SM, Schulzke JD (2016) The ginger component 6-shogaol prevents TNFα-induced barrier loss via inhibition of PI3K/Akt and NF-kB sigaling. Mol. Nutr. Food Res. 60(12): 2576-2586 (IF 4.3) [PubMed] [WebPage] [PDF]
Richter JF, Schmauder R, Krug SM, Gebert A, Schumann M (2016) A novel method for imaging sites of paracellular passage of macromolecules in epithelial sheets. J. Contr. Release 229: 70-79 (IF 7.8) [PubMed] [WebPage] [PDF] [Supplement] [Movie S1] [Movie S2]
2015
Dames P, Bergann T, Fromm A, Bücker R, Barmeyer C, Krug SM, Fromm M, Schulzke JD (2015) Interleukin-13 affects the intestinal epithelial sodium channel (ENaC) by coordinated modulation of STAT6 and p38 MAPK activity. J. Physiol. (Lond.) 593(24): 5269-5282 (IF 4.7) [PubMed] [WebPage] [PDF]
Khan RI, Uwada J, Yazawa T, Islam T, Krug SM, Fromm M, Karaki S, Suzuki Y, Kuwahara A, Yoshiki H, Sada K, Muramatsu I, Anisuzzaman AS, Taniguchi T (2015) Activation of muscarinic cholinoceptor (mAChR) ameliorates tumor necrosis factor-α-induced barrier dysfunction by the regulation of nuclear factor-κB signaling pathway in intestinal epithelial cells. FEBS Lett. 589(23): 3640-3647 (IF 3.5) [PubMed] [WebPage] [PDF]
2014
Sauer RS, Krug SM, Hackel D, Staat C, Konasin N, Yang S, Niedermirtl B, Bosten J, Günther R, Dabrowski S, Doppler K, Sommer C, Blasig IE, Brack A*, Rittner HL* (*shared last authorship) (2014) Safety, efficacy, and molecular mechanism of claudin-1-specific peptides to enhance blood-nerve-barrier permeability. J. Contr. Release 185: 88-98 (IF 7.7) [PubMed] [WebPage] [PDF] [Supplement]
Capaldo CT, Farkas AE, Hilgarth RS, Krug SM, Wolf MF, Benedik JK, Fromm M, Koval MH, Parkos CA, Nusrat A (2014) Proinflammatory cytokine-induced tight junction remodeling through dynamic self-assembly of claudins. Mol. Biol. Cell 25(18): 2710-2719 (IF 4.5) [PubMed] [WebPage] [PDF+Supplements]
Dittmann I, Amasheh M, Krug SM, Markov AG, Fromm M, Amasheh S (2014) Laurate permeabilizes the paracellular pathway for small molecules in the intestinal epithelial cell model HT-29/B6 via opening the tight junctions by reversible relocation of claudin-5. Pharm. Res. 31(9): 2539-2548 {Erratum correcting a misprint in the Title: Pharm. Res. 32(2): 737} (IF 3.4) [PubMed] [WebPage] [PDF]
Review
Krug SM, Schulzke JD, Fromm M (2014) Tight junction, selective permeability, and related diseases. Semin. Cell Devel. Biol. 36: 166-176 (IF 6.3) [PubMed] [WebPage] [PDF]
2013
Krug SM, Amasheh M, Dittmann I, Christoffel I, Fromm M, Amasheh S (2013) Sodium caprate as an enhancer of macromolecule permeation across tricellular tight junctions of intestinal cells. Biomaterials 34(1): 275-282 (IF 8.3) [PubMed] [WebPage] [PDF]
Dörfel MJ, Westphal JK, Bellmann C, Krug SM, Cording J, Mittag S, Tauber R, Fromm M, Blasig IE, Huber O (2013) CK2-dependent phosphorylation of occludin regulates the interaction with ZO-proteins and tight junction integrity. Cell Commun. Signal. 11(1): 40 (IF 4.7) [PubMed] [WebPage] [PDF]
Zakrzewski SS, Richter JF, Krug SM, Jebautzke B, Lee IM, Rieger J, Sachtleben M, Bondzio A, Schulzke JD, Fromm M, Günzel D (2013) Improved cell line IPEC-J2, characterized as a model for porcine jejunal epithelium. PLOS One 8(11): e79643 (print pages 1-12) (IF 3.5) [PubMed] [WebPage] [PDF] [Supplements]
2012
Krug SM, Günzel D, Conrad MP, Rosenthal R, Fromm A, Amasheh S, Schulzke JD, Fromm M (2012) Claudin-17 forms tight junction channels with distinct anion selectivity. Cell. Mol. Life Sci. 69(16): 2765-2778 (IF 5.6) [PubMed] [WebPage] [PDF] [Supplement]
Hackel D, Krug SM, Sauer RS, Mousa SA, Böcker A, Pflücke D, Wrede EJ, Kistner K, Hoffmann T, Niedermirtl B, Sommer C, Bloch L, Huber O, Blasig IE, Amasheh S, Reeh PW, Fromm M, Brack A, Rittner HL (2012) Transient opening of the perineurial barrier for analgesic drug delivery. Proc. Natl. Acad. Sci. USA 109(29): E2018-E2027 (IF 9.7) [PubMed] [WebPage] [PDF]
Rosenthal R*, Günzel D* (*shared first authorship), Finger C, Krug SM, Richter JF, Schulzke JD, Fromm M, Amasheh S (2012) The effect of chitosan on transcellular and paracellular mechanisms in the intestinal epithelial barrier. Biomaterials 33(9): 2791-2800 (IF 7.6) [PubMed] [WebPage] [PDF] [Supplement]
Shalapour S, Deiser K, Kühl AA, Glauben R, Krug SM, Fischer A, Sercan Ö, Chappaz S, Bereswill S, Heimesaat MM, Loddenkemper C, Fromm M, Finke D, Hämmerling GJ, Arnold B, Siegmund B, Schüler T (2012) Interleukin-7 links T lymphocyte and intestinal epithelial cell homeostasis. PLOS One 7(2): e31939 (print pages 1-11) (IF 3.7) [PubMed] [WebPage] [PDF]
Takahashi A*, Saito Y*, Kondoh M*°, Matsushita K, Krug SM, Suzuki H, Tsujino H, Li X, Aoyama H, Matsuhisa K, Uno T, Fromm M, Hamakubo T, Yagi K (2012) Creation and biochemical analysis of a broad-specific claudin binder. Biomaterials 33(12): 3464-3474 (IF 7.6) [PubMed] [WebPage] [PDF] (*shared first authorship, °corresponding author)
Veshnyakova A, Krug SM, Mueller SL, Piontek J, Protze J, Fromm M, Krause G (2012) Determinants contributing to claudin ion channel formation. Ann. N.Y. Acad. Sci. 1257: 45-53 (IF 4.4) [PubMed] [WebPage] [PDF] (Original paper)
Reviews
Krug SM, Günzel D, Conrad MP, Lee IM, Amasheh S, Fromm M, Yu ASL (2012) Charge-selective claudin channels. Ann. N.Y. Acad. Sci. 1257: 20-28 (IF 4.4) [PubMed] [WebPage] [PDF]
Günzel D, Zakrzewski S, Schmid T, Pangalos M, Wiedenhoeft J, Blasse C, Ozboda C, Krug SM (2012) From TER to trans- and paracellular resistance: Lessons from impedance spectroscopy. Ann. N.Y. Acad. Sci. 1257: 142-151 (IF 4.4) [PubMed] [WebPage] [PDF]
2011
Bücker R, Krug SM, Rosenthal R, Günzel D, Fromm A, Zeitz M, Chakraborty T, Fromm M, Epple HJ, Schulzke JD (2011) Aerolysin from Aeromonas hydrophila perturbs tight junction integrity and cell lesion repair in intestinal epithelial HT-29/B6 cells. J. Infect. Dis. 204 (8): 1283-1292 (IF 6.4) [PubMed] [WebPage] [PDF]
Hering NA, Richter JF, Krug SM, Günzel D, Fromm A, Bohn E, Rosenthal R, Bücker R, Fromm M, Troeger H, Schulzke JD (2011) Yersinia enterocolitica induces epithelial barrier dysfunction through regional tight junction changes in colonic HT-29/B6 cell monolayers. Lab. Invest. 91(2): 310-324 (IF 3.6) [PubMed] [WebPage] [PDF] [Supplement]
2010
Amasheh M, Fromm A, Krug SM, Amasheh S, Andres S, Zeitz M, Fromm M, Schulzke JD (2010) TNFa-induced and berberine-antagonized tight junction barrier impairment via tyrosine kinase, pAkt, and NFkB signaling. J. Cell Sci. 123(23): 4145-4155 (IF 6.3) [PubMed] [WebPage] [PDF] [Supplements]
Milatz S, Krug SM, Rosenthal R, Günzel D, Müller D, Schulzke JD, Amasheh S*, Fromm M* (*shared last authorship) (2010) Claudin-3 acts as a sealing component of the tight junction for ions of either charge and uncharged solutes. Biochim. Biophys. Acta Biomembr. 1798: 2048-2057 (IF 4.6) [PubMed] [WebPage] [PDF]
Rosenthal R, Milatz S,
Krug SM, Oelrich B, Schulzke JD, Amasheh S, Günzel D, Fromm M (2010)
Claudin-2, a component of the tight junction, forms a paracellular water
channel. J. Cell Sci.
123(11): 1913-1921
(IF 6.3) [PubMed]
[WebPage] [PDF]
[Supplement]
Westphal JK, Dörfel MJ, Krug SM, Cording JD, Piontek J, Blasig IE, Tauber R, Fromm M, Huber O (2010) Tricellulin forms homomeric and heteromeric tight junctional complexes. Cell. Mol. Life Sci. 67(12): 2057-2068 (IF 7.0) [PubMed] [WebPage] [PDF] [Supplement]
Review / book chapter
Günzel D, Krug SM, Rosenthal R, Fromm M (2010) Biophysical methods to study tight junction permeability. Curr. Top. Membr. 65: 39-78 (IF 0.7) [Directory] [WebPage] [PDF]
2009
Krug SM,
Amasheh S, Richter JF, Milatz S, Günzel D, Westphal JK, Huber O, Schulzke
JD, Fromm M (2009) Tricellulin forms a barrier to macromolecules in
tricellular tight junctions without affecting ion permeability.
Mol. Biol. Cell
20: 3713-3724 (IF 6.0) [PubMed]
[WebPage]
[PDF] [Supplement
text] [Supplement
video]
Krug SM, Fromm M, Günzel D (2009) Two-path impedance spectroscopy for measuring paracellular and transcellular epithelial resistance. Biophys. J. 97(8): 2202-2211 (IF 4.4) [PubMed] [WebPage] [PDF] [Supplement]
Amasheh S*, Milatz S* (*shared first authorship), Krug SM, Bergs M, Amasheh M, Schulzke JD, Fromm M (2009) Na+ absorption defends from paracellular back-leakage by claudin-8 upregulation. Biochem. Biophys. Res. Comm. 378(1): 45-50 (IF 2.5) [PubMed] [WebPage] [PDF]
Günzel D, Stuiver M, Kausalya PJ, Haisch L, Krug SM, Rosenthal R, Meij IC, Hunziker W, Fromm M, Müller D (2009) Claudin-10 exists in six alternatively spliced isoforms which exhibit distinct localization and function. J. Cell Sci. 122: 1507-1517 (IF 6.1) [PubMed] [WebPage] [PDF]
Mankertz J*, Amasheh M* (*shared first authorship), Krug SM, Fromm A, Amasheh S, Hillenbrand B, Tavalali S, Fromm M, Schulzke JD (2009) TNFalpha up-regulates claudin-2 expression in epithelial HT-29/B6 cells via phosphatidylinositol-3-kinase signaling. Cell Tiss. Res. 336(1): 67-77 (IF 2.3) [PubMed] [WebPage] [PDF]
Ziera T, Irlbacher H, Fromm A, Latouche C, Krug SM, Fromm M, Jaisser F, Borden SA (2009) Cnksr3 is a direct mineralocorticoid receptor target gene and plays a key role in the regulation of the epithelial sodium channel. FASEB J. 23(11): 3936-3946 (IF 6.4) [PubMed] [WebPage] [PDF]
Reviews
Amasheh S, Milatz S, Krug SM, Markov AG, Günzel D, Amasheh M, Fromm M (2009) Tight junction proteins as channel formers and barrier builders: claudin-2, -5, and -8. Ann. N.Y. Acad. Sci. 1165: 211-219 (IF 2.7) [PubMed] [WebPage] [PDF]
Fromm M, Krug SM, Zeissig S, Richter JF, Rosenthal R, Schulzke JD, Günzel D (2009) High resolution analysis of barrier function. Ann. N.Y. Acad. Sci. 1165: 74-81 (IF 2.7) [PubMed] [WebPage] [PDF]
Günzel D, Haisch L, Pfaffenbach S, Krug SM, Milatz S, Amasheh S, Hunziker W, Müller D (2009) Claudin function in the thick ascending limb of Henle's loop. Ann. N.Y. Acad. Sci. 1165: 152-162 (IF 2.7) [PubMed] [WebPage] [PDF]
Theses
Krug SM (2016) Tight Junction-Proteine als regulierbare Kanal- und Barrierebildner. Habilitation thesis, Experimental biomedicine, Charité - Universitätsmedizin Berlin
Krug SM (2009) Tricellulin und seine Funktion in der trizellulären Tight Junction von Epithelzellen. Doctoral thesis, Biochemistry, Freie Universität Berlin
Krug SM (2006) Transfektion von MDCK-Zellen mit Claudin-12-cDNA und Analyse der differenzierungsabhängigen Expression von Tight Junction-Proteinen. Diploma thesis, Biochemistry, Freie Universität Berlin
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