Medizinische Klinik für Gastroenterologie, Infektiologie und Rheumatologie (einschl. Arbeitsbereich Ernährungsmedizin) CBF
Clinical Physiology / Nutritional Medicine

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Publications: Susanne M. Krug home page

- Papers (PubMed): 94
-
h-index (Web of Science): 34

2025

  • Deshpande D, Velleman L, Schmitz J, Forster PM, Schinke C, Boulekou S, Düsedau HP, Krug SM, Mertens T, Gao X, Figueiredo C, Jarick KJ, Plum T, Sterczyk N, Leclère PS, Helfrich S, Tappe-Theodor A, Kotsch K, Steffen J, Voehringer D, Duerr CU, Hauser AE, Artis D, Pitzer C, Dunay IR, Klose CSN (2025) Group 2 innate lymphoid cells regulate nociceptive and gait functions of the peripheral nervous system. Sci. Immunol. 10(111): eadp7092 (17 pages). doi: 10.1126/sciimmunol.adp7092 (°IF 16.3)

  • Hagen KD, Nosala C, Müller A, Hilton NA, Holthaus D, Schulzke JD, Krug SM, Hoffmann T, Laue M, Klotz C, Aebischer A, Dawson SC (2025) Giardia's domed ventral disc architecture is essential for attachment and contributes to epithelial barrier disruption. Mol. Biol. Cell 36(8): ar93. doi: 10.1091/mbc.E23-12-0515 (°IF 2.7)

  • Atalla MS, Bettenhausen A-L, Verse JM, Cebulla N, Krug SM, Sauer R-S, Srivastava M, Bischler T, Chen JTC, Kortüm KM, Kittel RJ, Sommer C,  Rittner HL (2025) Neuronal toxicity and recovery from early bortezomib-induced neuropathy: blood nerve barrier dysfunction without dorsal root ganglion damage. Br. J. Anaesth. (online ahead of print) S0007-0912(25)00366-6 (12 pages). doi: 10.1016/j.bja.2025.05.046 (°IF 9.2)

  • Krug SM*, Lee IM*, Knobe L* (*shared first authorship), Hartmannsberger B, Atalla MS, Rittner HL, Fromm M (2025) Characterising epi-perineurial barrier function by microscale techniques including a miniaturised Ussing chamber. Acta Biomater. 199: 290-300. doi: 10.1016/j.actbio.2025.04.043 (°IF 9.6)

  • Martínez-Perafán F, Fromm A, van der Veen RE, Waldow A, Lehmann M, Krug SM, Günzel D, Rosenthal R, Fromm M, Piontek J (2025) Effect of claudin-1 or -3 expression on cation and water channel properties of claudin-2. BBA - Mol. Cell Res. 1872(4): 119930 (17 pages). doi: 10.1016/j.bbamcr.2025.119930 (°IF 3.7)

  • Bao LL, Yu YQ, González-Acera M, Patankar JV, Giessl A, Sturm G, Kühl AA, Atreya R, Erkert L, Gámez-Belmonte R, Krug SM, Schmid B, Tripal P, Chiriac M, Hildner K, Siegmund B, Wirtz S, Stürzl M, Abdou MM, Trajanoski Z, The TRR241 IBDome Consortium, Neurath MF, Zorzano A, Becker C (2025) Epithelial OPA1 links mitochondrial fusion to inflammatory bowel disease. Science Transl. Med. 17: eadn8699 (15 pages). doi: 10.1126/scitranslmed.adn8699 (°IF 14,6)

  • Hartmannsberger B, Ben-Kraiem A, Kramer S, Guidolin C, Kazerani I, Doppler K, Thomas D, Gurke R, Sisignano M, Kalelkar PP, García AJ, Monje PV, Sammeth M, Nusrat A, Brack A, Krug SM, Sommer C, Rittner HL (2025) TAM receptors mediate the Fpr2-driven pain resolution and fibrinolysis after nerve injury. Acta Neuropathol. 149(1): 1 (21 pages). doi: 10.1007/s00401-024-02840-9 (°IF 9.3)

  • Marinovic I, Bartosova M, Levai E, Herzog R, Saleem A, Du Z, Zhang C, Sacnun JM, Pitaraki E, Sinis S, Damgov I, Krunic D, Lajqi T, Al-Saeedi M, Szabo JA, Hausmann M, Domonkos P, Kratochwill K, Krug SM, Zarogiannis SG, Schmitt CP (2025) Molecular and functional characterization of the peritoneal mesothelium, a barrier for solute transport. Function 6(1): zqae051 (12 pages), doi: 10.1093/function/zqae051 (°IF 3.8)

    • Review

  • Liebing E*, Krug SM* (*shared first authorship), Neurath MF, Siegmund B, Becker C (2025) Wall of resilience: How the intestinal epithelium prevents inflammatory onslaught in the gut. Cell. Mol. Gastroenterol. Hepatol. 19)2): 101423 (17 pages) doi:10.1016/j.jcmgh.2024.101423 (°IF 7.4)

2024

2023

2022

2021

2020

2019

  • Ayala-Torres C, Krug SM, Schulzke JD, Rosenthal R*, Fromm M* (*shared last authorship) (2019) Tricellulin effect on paracellular water transport. Int. J. Mol. Sci. 20(22): 5700 (15 pages) doi: 10.1016/j.cellsig.2019.109358 (IF 4.6)

  • Reinhold AK, Yang S, Chen JT, Hu L, Sauer RS, Krug SM, Mambretti E, Fromm M, Brack A, Rittner HL (2019) Tissue plasminogen activator and neuropathy open the blood-nerve barrier with upregulation of miR-155-5p in male rats. Biochim. Biophys. Acta - Mol. Basis Dis. 1865(6): 1160-1169 doi: 10.1016/j.cellsig.2019.109358 (IF 4.5)

  • Uwada J, Yazawa T, Mikami D, Krug SM, Fromm M, Sada K, Muramatsu I, Taniguchi T (2019) Store-operated calcium entry (SOCE) contributes to phosphorylation of p38 MAPK and suppression of TNF-α signalling in the intestinal epithelial cells. Cell. Signalling 63: 109358 (10 pages) doi: 10.1016/j.cellsig.2019.109358 (IF 4.0)

    • Review

  • Hashimoto Y, Tachibana K, Krug SM, Kunisawa J, Fromm M, Kondoh M (2019) Potential for tight junction protein-directed drug development using claudin binders and angubindin-1. Int. J. Mol. Sci. 20 (16): 4016 (17 pages) doi: 10.3390/ijms20164016 (IF 4.6)

2018

  • Krug SM, Bojarski C, Fromm A, Lee IM, Dames P, Richter JF, Turner JR, Fromm M*, Schulzke JD* (*shared last authorship) (2018) Tricellulin is regulated via interleukin-13-receptor α2, affects macromolecule uptake, and is decreased in ulcerative colitis. Mucosal Immunol. 11(2): 345-356 (IF 7.4) [PubMed] [WebPage] [PDF] [Supplement] [Supplementary Movie]

  • Blecharz-Lang KG, Prinz V, Burek M, Frey D, Schenkel T, Krug SM, Fromm M, Vajkoczy P (2018) Gelatinolytic activity of autocrine matrix metalloproteinase-9 leads to endothelial de-arrangement in Moyamoya disease. J. Cereb. Blood Flow Metab. 38(11): 1940-1953 (IF 6.0) [PubMed] [DOI] [PDF] [Supplement]

  • Bücker R, Krug SM, Moos V, Bojarski C, Schweiger MR, Kerick M, Fromm A, Janßen S, Fromm M, Hering NA, Siegmund B, Schneider T, Barmeyer C, Schulzke JD (2018) Campylobacter jejuni impairs sodium transport and epithelial barrier function via cytokine release in human colon. Mucosal Immunol. 11(2): 474-485 (IF 7.4) [PubMed] [DOI] [PDF] [Supplement1] [Supplement2]

2017

  • Krug SM (2017) Contribution of the tricellular tight junction to paracellular permeability in leaky and tight epithelia. Ann. N.Y. Acad. Sci. 1397: 219-230 (IF 4.3) [PubMed] [WebPage] [PDF]

  • Krug SM, Hayaishi T, Iguchi D, Watari A, Takahashi A, Fromm M, Nagahama M, Takeda H, Okada Y, Sawasaki T, Doi T, Yagi K, Kondoh M (2017) Angubindin-1, a novel paracellular absorption enhancer acting at the tricellular tight junction. J. Contr. Release 260: 1-11 (IF 7.9) [PubMed] [WebPage] [PDF] [Supplement]

  • Schütz A, Radusheva V, Krug SM*, Heinemann U* (*shared last authorship) (2017) Crystal structure of the tricellulin C-terminal coiled-coil domain reveals a unique mode of dimerization. Ann. N.Y. Acad. Sci. 1405: 147-159 (IF 4.3) [PubMed] [WebPage] [PDF] [Supplement]

  • Blecharz KG*, Frey D* (*shared first authorship), Schenkel T, Prinz V, Bedini G, Krug SM, Czabanka M, Wagner J, Fromm M, Bersano A, Vajkoczy P (2017) Autocrine release of angiopoietin-2 mediates cerebrovascular disintegration in Moyamoya disease. J. Cereb. Blood Flow Metab. 37(4): 1527-1539 (IF 6.0) [PubMed] [WebPage] [PDF] [Supplement]

  • Bücker R, Krug SM, Fromm A, Nielsen HL, Fromm M, Nielsen H, Schulzke JD (2017) Campylobacter fetus impairs barrier function in HT-29/B6 cells through focal tight junction alterations and leaks. Ann. N.Y. Acad. Sci. 1405: 189-201 (IF 4.3) [PubMed] [WebPage] [PDF]

  • Cording J*, Arslan B* (*shared first authorship), Staat C, Dithmer S, Krug SM, Krüger A, Berndt P, Günther R, Winkler L, Blasig IE, Haseloff RF (2017) Trictide, a tricellulin-derived peptide to overcome cellular barriers. Ann. N.Y. Acad. Sci. 1405: 89-101 (IF 4.3) [PubMed] [WebPage] [PDF]

  • Epple HJ*, Friebel J*, Moos V* (*shared first authorship), Troeger H, Krug SM, Allers K, Schinnerling K, Fromm A, Siegmund B, Fromm M, Schulzke JD°, Schneider T° (°shared last authorship) (2017) Architectural and fuctional alterations of the small intestinal mucosa in classical Whipple's disease. Mucosal Immunol. 10(6): 1542-1552 (IF 7.4) [PubMed] [DOI] [PDF] [Supplement]

  • Hering NA, Luettig J, Krug SM, Wiegand S, Gross G, van Tol EA, Schulzke JD*, Rosenthal R* (*shared last authorship) (2017) Lactoferrin protects against intestinal inflammation or bacteria-induced barrier dysfunction in vitro. Ann. N.Y. Acad. Sci. 1405: 177-188 (IF 4.3) [PubMed] [WebPage] [PDF]

  • Rosenthal R, Günzel D, Krug SM, Schulzke JD, Fromm M, Yu ASL (2017) Claudin-2-mediated cation and water transport share a common pore. Acta Physiol. 219(2): 521-536 (IF 5.9) [PubMed] [WebPage] [PDF]

  • Rosenthal R, Luettig J, Hering NA, Krug SM, Albrecht U, Fromm M, Schulzke JD (2017) Myrrh exerts barrier-stabilizing and -protective effects in HT-29/B6 and Caco-2 intestinal epithelial cells. Int. J. Colorectal Dis. 32(5): 623-634 (IF 2.5) [PubMed] [WebPage] [PDF]

  • Uwada J, Yazawa T, Islam MT, Khan MRI, Krug SM, Fromm M, Karaki SI, Suzuki Y, Kuwahara A, Yoshiki H, Sada K, Muramatsu I, Taniguchi T (2017) Activation of muscarinic receptors prevents TNF-α-mediated intestinal epithelial barrier disruption through p38 MAPK. Cell. Signal. 35: 188-196 (IF 3.5) [PubMed] [WebPage] [PDF]

    • Review

  • Fromm M, Piontek J, Rosenthal R, Günzel D, Krug SM (2017) Tight junctions of the proximal tubule and their channel proteins. Pflügers Arch. 469(7-8): 877-887 (IF 2.8) [PubMed] [WebPage] [PDF]

  • Martini E, Krug SM, Siegmund B, Neurath MF, Becker C (2017) Mend your fences: The epithelial barrier and its relationship with mucosal immunity in inflammatory bowel disease. Cell. Mol. Gastroent. Hepatol. 4(1): 33-46 (new journal, no IF yet)  [PubMed] [WebPage] [PDF]

2016

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2012

2011

2010

2009


Theses