Publications:  Jörg-Dieter Schulzke

PubMed list of Jörg Schulzke,
listed papers: 248, h-index: 63

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  • Awad K, Barmeyer C, Bojarski C, Nagel O, Lee IM, Schweiger MR, Schulzke JD*, Bücker R* (*shared last authorship) (2023) Impaired intestinal permeability of tricellular tight junctions in patients with irritable bowel syndrome with mixed bowel habits (IBS-M). Cells 12(2), 236 (19 pages); doi: 10.3390/cells12020236, Supplement (°IF 6.0)

  • Friebel J, Schinnerling K, Weigt K, Heldt C, Fromm A, Bojarski C, Siegmund B, Epple HJ, Kikhney J, Moter A, Schneider T, Schulzke JD, Moos V, Schumann M (2023) Uptake of Tropheryma whipplei by intestinal epithelia. Int. J. Mol. Sci. 24(7): 6197 (20 pages) doi: 10.3390/ijms24076197 (°IF 5.6)

  • Heils L, Schneemann M, Gerhard R, Schulzke JD, Bücker R (2023) CDT of Clostridioides difficile induces MLC-dependent intestinal barrier dysfunction in HT-29/B6 epithelial cell monolayers. Toxins (Basel) 15(1): 54 (15 pages). doi: 10.3390/toxins15010054 (°IF 4.2)

  • Krug SM, Grünhagen C, Allers K, Bojarski C, Seybold J, Schneider T, Schulzke JD, Epple HJ (2023) Macromolecule translocation across the intestinal mucosa of HIV-infected patients by transcytosis and through apoptotic leaks. Cells 12(14): 1887 (13 pages). doi: 10.3390/cells12141887 (°IF 6.0)

  • Omarova S, Awad K, Moos V, Püning C, Gölz G, Schulzke JD, Bücker R (2023) Intestinal barrier in post-Campylobacter jejuni irritable bowel syndrome. Biomolecules 13(3): 449 (14 pages). doi: 10.3390/biom13030449 (°IF 5.5)


  • Holthaus D*, Kraft MR* (*shared first authorship), Krug SM, Wolf S, Müller A, Delgado Betancourt E, Schorr M, Holland G, Knauf F, Schulzke JD, Aebischer T°, Klotz C° (°shared last authorship) (2022) Dissection of barrier dysfunction in organoid-derived human intestinal epithelia induced by Giardia duodenalis. Gastroenterology 162(3): 844-858, (IF 29.4)

  • Kaak JL, Lobo de Sá FD, Turner JR, Schulzke JD, Bücker R (2022) Unraveling the intestinal epithelial barrier in cyanotoxin microcystin-treated Caco-2 cell monolayers. Ann. NY Acad. Sci. 1516(1): 188-196, doi: 10.1111/nyas.14870 (IF 5.2)

  • Warschkau D, Delgado-Betancourt E, Holthaus D, Müller A, Kliem G, Krug SM, Schulzke JD, Aebischer T, Klotz C*, Seeber F* (*shared last authorship) (2022). From 3D to 2D: Harmonization of protocols for two-dimensional cultures on cell culture inserts of intestinal organoids from various species. Bio-protocol 12(2): e4295 (25 pages). doi: 10.21769/BioProtoc.4295

  • Weiß F, Holthaus D, Kraft M, Klotz C, Schneemann M, Schulzke JD, Krug SM (2022) Human duodenal organoid derived monolayers serve as a suitable barrier model for duodenal tissue. Ann. NY Acad. Sci. 1515(1): 155-167, doi: 10.111/nyas.14804 (IF 5.2)

  • Zejc T, Piontek J, Schulzke JD, Fromm M, Ervens J*, Rosenthal R* (*shared last authorship) (2022) Clinical significance of claudin expression in oral squamous cell carcinoma. Int. J. Mol. Sci. 23(19): 11234 (13 pages), doi: 10.3390/ijms231911234 (IF 5.6)


  • Hering NA, Luettig J, Jebautzke B, Schulzke JD, Rosenthal R (2021) The punicalagin metabolites ellagic acid and urolithin A exert different strengthening and anti-inflammatory effects on tight junction-mediated intestinal barrier function in vitro. Front. Pharmacol. 12: 610164, doi: 10.3389/fphar.2021.610164 (IF 6.0)

  • Hu JCE, Weiß F, Bojarski C, Branchi F, Schulzke JD, Fromm M, Krug SM (2021) Expression of tricellular tight junction proteins and the paracellular macromolecule barrier are recovered in remission of ulcerative colitis. BMC Gastroenterology 21(1): 141, doi: 10.1186/s12876-021-01723-7 (IF 2.9) 

  • Lobo de Sá FD, Backert S, Nattramilarasu PK, Mousavi S, Sandle GI, Bereswill S, Heimesaat MM, Schulzke JD, Bücker R (2021) Vitamin D reverses disruption of gut epithelial barrier function caused by Campylobacter jejuni. Int. J. Mol. Sci. 22(16): 8872 (16 pages). doi: 10.3390/ijms22168872 (IF 6.2)

  • Lobo de Sá FD, Heimesaat MM, Bereswill S, Nattramilarasu PK, Schulzke JD, Bücker R (2021) Resveratrol prevents Campylobacter jejuni-induced leaky gut by restoring occludin and claudin-5 in the paracellular leak pathway. Front. Pharmacol. 12: 640572. doi: 10.3389/fphar.2021.640572 (IF 6.0)

  • Lobo de Sá FD, Schulzke JD, Bücker R (2021) Diarrheal mechanisms and the role of intestinal barrier dysfunction in Campylobacter infections. Curr. Top. Microbiol. Immunol. 431: 203-231. doi: 10.1007/978-3-030-65481-8_8  (IF 4.7)

  • Nattramilarasu PK, Lobo de Sá FD, Schulzke JD, Bücker R (2021) Immune-mediated aggravation of the Campylobacter concisus-induced epithelial barrier dysfunction. Int. J. Mol. Sci. 22(4): 2043 (23 pages). doi: 10.3390/ijms22042043, Supplement PDF (IF 6.2)

  • Schulz E, Schumann M, Schneemann M, Dony V, Fromm A, Nagel O, Schulzke JD, Bücker R (2021) Escherichia coli alpha-hemolysin HlyA induces host cell polarity changes, epithelial barrier dysfunction and cell detachment in human colon carcinoma Caco-2 cell model via PTEN-dependent dysregulation of cell junctions. Toxins 13(8): 520 (22 pages). doi: 10.3390/toxins13080520. (IF 5.1)


  • Heimesaat MM, Mousavi S, Escher U, Lobo de Sá FD, Peh E, Schulzke JD, Kittler S, Bücker R, Bereswill S (2020) Resveratrol alleviates acute Campylobacter jejuni-induced enterocolitis in a preclinical murine intervention study. Microorganisms 8: 1858 (15 pages) (IF 4.1) [PubMed] [DOI] [PDF] [Supplement]

  • Bücker R, Zakrzewski SS, Wiegand S, Pieper R, Fromm A, Fromm M, Günzel D, Schulzke JD (2020) Zinc prevents intestinal epithelial barrier dysfunction induced by alpha-hemolysin-producing Escherichia coli 536 infection in porcine colon. Vet. Microbiol. 243: 108632 (6 pages) [PubMed] [WebPage] [PDF] [Supplement] (IF 3.3)

  • Nattramilarasu PK, Bücker R, Lobo de Sá FD, Fromm A, Nagel O, Lee IM, Butkevych E, Mousavi S, Genger C, Kløve S, Heimesaat MM, Bereswill S, Schweiger MR, Nielsen HL, Troeger H, Schulzke JD (2020) Campylobacter concisus impairs sodium absorption in colonic epithelium via ENaC dysfunction and claudin-8 disruption. Int. J. Mol. Sci. 21(2): e373 (23 pages) (IF 5.9) [PubMed] [WebPage] [PDF] [Supplements]

  • Kjærgaard S, Damm MMB, Chang J, Riis LB, Rasmussen HB, Hytting-Andreasen R, Krug SM, Schulzke JD, Bindslev N, Berner-Hansen M (2020) Altered structural expression and enzymatic activity parameters in quiescent ulcerative colitis: Are these potential normalization criteria? Int. J. Mol. Sci. 21(5): e1887 (18 pages) (IF 5.9) [PubMed] [WebPage] [PDF]

    • Book chapter

  • Schulzke JD, Fromm M (2020) Chapter 3: Role of the epithelium in diseases of the intestine, in: Ion transport across epithelial tissues and disease, Vol. 2: Ion channels and transporters of epithelia in health and disease. p 77-109. In: Hamilton KL, Devor DC (eds.), 2. edn., Springer / Am. Physiol. Soc. [DOI] [PDF whole book] [Amazon] [Springer]



  • Bücker R, Krug SM, Moos V, Bojarski C, Schweiger MR, Kerick M, Fromm A, Janßen S, Fromm M, Hering NA, Siegmund B, Schneider T, Barmeyer C, Schulzke JD (2018) Campylobacter jejuni impairs sodium transport and epithelial barrier function via cytokine release in human colon. Mucosal Immunol. 11(2): 474-485 (IF 7.4) [PubMed] [DOI] [PDF] [Supplement1] [Supplement2]

  • Eichner M, Augustin C, Fromm A, Piontek A, Walther W, Bücker R, Fromm M, Krause G, Schulzke JD, Günzel D, Piontek J (2018) In colon epithelia, Clostridium perfringens enterotoxin causes focal leaks by targeting claudins which are apically accessible due to tight junction derangement. J. Infect. Dis. 217(1): 147-157 (IF 5.0) [PubMed] [WebSite] [PDF]

  • Krug SM, Bojarski C, Fromm A, Lee IM, Dames P, Richter JF, Turner JR, Fromm M*, Schulzke JD* (*shared last authorship) (2018) Tricellulin is regulated via interleukin-13-receptor α2, affects macromolecule uptake, and is decreased in ulcerative colitis. Mucosal Immunol. 11(2): 345-356 (IF 7.4) [PubMed] [DOI] [PDF] [Supplement] [Supplementary Movie]

  • Neuhaus W, Piontek A, Protze J, Eichner M, Mahringer A, Subileau EA, Lee IM, Schulzke JD, Krause G, Piontek J (2018) Reversible opening of the blood-brain barrier by claudin-5-binding variants of Clostridium perfringens enterotoxin's claudin-binding domain. Biomaterials 161: 129-143 (IF 10.3) [PubMed] [WebPage] [PDF]

  • Troeger H, Hering NA, Bojarski C, Fromm A, Barmeyer C, Uharek L, Siegmund B, Fromm M, Rieger K*, Schulzke JD* (*shared last authorship) (2018) Epithelial barrier dysfunction as permissive pathomechanism in human intestinal graft-versus-host disease. Bone Marrow Transplant. 53(8): 1083-1086 (IF 4.7) [PubMed] [WebPage] [PDF]

    • Review

  • Stein J, Schulzke JD, Schuppan D (2018) Medikamentöse Therapie der Zöliakie – „from bench to bedside“. Z. Gastroenterol. 56(2): 151-164 (IF 1.2) [PubMed] [WebPage] [PDF] 





  • Whelan RA*, Rausch S* (*shared first authorship), Ebner F, Günzel D, Richter JF, Hering NA, Schulzke JD, Kühl AA, Keles A, Janczyk P, Nöckler K, Wieler LH, Hartmann S (2014) A transgenic probiotic secreting a parasite immunomodulator for site-directed treatment of gut inflammation. Mol. Ther. 22(10): 1730-1740 (IF 6.2) [PubMed] [WebPage] [PDF]

  • Bücker R, Schulz E, Günzel D, Bojarski C, Lee IM, John LJ, Wiegand S, Janßen T, Wieler LH, Dobrindt U, Beutin L, Ewers C, Fromm M, Siegmund B, Troeger H, Schulzke JD (2014) α-Haemolysin of Escherichia coli: a potentiator of inflammatory activity in the colon. Gut 63(12): 1893-1901 (IF 14.7) [PubMed] [WebPage] [PDF] [Supplements]

  • Hering NA*, Richter JF* (*shared first authorship), Fromm A, Wieser A, Hartmann S, Günzel D, Bücker R, Fromm M, Schulzke JD° (°corresponding author), Troeger H (2014) TcpC protein from E. coli Nissle improves epithelial barrier function involving PKCζ and ERK1/2 signalling in HT-29/B6 cells. Mucosal Immunol. 7(2): 369-378 (IF 7.4) [PubMed] [WebPage] [PDF]

  • Norman K, Stobäus N, Kulka K, Schulzke JD (2014) Effect of inflammation on handgrip strength in the non-critically ill is independent from age, gender and body composition. Eur. J. Clin. Nutr. 68(2): 155-158 (IF 2.7) [PubMed] [WebPage]

  • Richter JF, Pieper R, Zakrzewski SS, Günzel D, Schulzke JD, Van Kessel AG (2014) Diets high in fermentable protein and fiber alter tight junction protein composition with minor effect on barrier function in piglet colon. Br. J. Nutr. 111(6): 1040-1049 (IF 3.5) [PubMed] [WebPage] [PDF] [Supplements

  • Valentini L, Ramminger S, Haas V, Postrach E, Werich M, Fischer A, Koller M, Swidsinski A, Bereswill S, Lochs H, Schulzke JD (2014) Small intestinal permeability in older adults. Physiol. Rep. 2(4): e00281 (print pages 1-10) (new journal) [PubMed] [WebPage] [PDF]

  • Yu C, Achazi K, Möller L, Schulzke JD, Niedrig M, Bücker R (2014) Tick-borne encephalitis virus replication, intracellular trafficking, and pathogenicity in human intestinal Caco-2 cell monolayers. PLOS One 9(5): e96957 (print pages 1-10) (IF 3.2) [PubMed ] [WebPage] [PDF

    • Review

  • Bischoff SC, Barbara G, Buurman W, Ockhuizen T, Schulzke JD, Serino M, Tilg H, Watson A, Wells J (2014) Intestinal permeability – a new target for disease prevention and therapy? BMC Gastroent. 14: 189 (IF 2.4) (Review, print pages 1-25) [PubMed] [WebPage] [PDF]

  • Luettig J, Rosenthal R, Barmeyer C, Schulzke JD (2014) Claudin-2 as mediator of leaky gut barrier during intestinal inflammation. Tiss. Barriers 3(1-2): e977176 (new journal) Invited Review, Special Issue "Tissue Barriers in Inflammation" [10.10.14 accepted

  • Wallace MB, Vazquez-Roque M, Bojarski C, Schulzke JD (2014) Imaging the leaky gut. Gastroenterology 147(5): 952-954 (IF 16.7) (Editorial) [PubMed] [WebPage] [PDF]

  • Krug SM, Schulzke JD, Fromm M (2014) Tight junction, selective permeability, and related diseases. Semin. Cell Devel. Biol. 36: 166-176 (IF 6.3) [PubMed] [WebPage] [PDF]

  • Schulzke JD, Siegmund B, Günzel D (2014) New insights in intestinal secretion. Gut 63: 1371-1372 (IF 14.7) (Commentary) [PubMed] [WebPage] [PDF]


  • Postrach E, Aspalter R, Elbelt U, Koller M, Longin R, Schulzke JD, Valentini L (2013) Determinants of successful weight loss after using a commercial web-based weight reduction program for six months: cohort study. J. Med. Internet Res. 15(10): e219 (IF 3.8) [PubMed] [WebPage]

  • Schmidt C, Lautenschlaeger C, Collnot EM, Schumann M, Bojarski C, Schulzke JD, Lehr CM, Stallmach A (2013) Nano- and microscaled particles for drug targeting to inflamed intestinal mucosa: a first in vivo study in human patients. J. Control. Release 165(2): 139-145 (IF 7.6) [PubMed] [WebPage] [PDF]

  • Zakrzewski SS, Richter JF, Krug SM, Jebautzke B, Lee IM, Rieger J, Sachtleben M, Bondzio A, Schulzke JD, Fromm M, Günzel D (2013) Improved cell line IPEC-J2, characterized as a model for porcine jejunal epithelium. PLOS One 8(11): e79643 (print pages 1-12) (IF 3.7) [PubMed] [WebPage] [PDF] [Supplements]

    • Textbook chapter

  • Schulzke JD, Fromm M, Berger EG, Bieber J (2013) Chapter 14 "Magen-Darm-Trakt, Pankreas und Leber", In: Physiologie. Speckmann EJ, Hescheler J, Köhling R (eds.), 6. edn., Elsevier, München. ISBN 978-3-437-41319-3, p 529-567 [Publisher] [Textbook of Physiology]














    Ann. N.Y. Acad. Sci. 915




1995 - 1996

1994 - 1995

1991 - 1992



1988 - 1987

1986 - 1985