Publications:  Jörg Piontek

PubMed list of Jörg Piontek,
listed items: 62, h-index: 30
update 11.03.2024

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  • Nagarajan SK, Piontek J (2024) Molecular dynamics simulations of claudin-10a and -10b ion channels: With similar architecture, different pore linings determine the opposite charge selectivity. Int. J. Mol. Sci. 25(6): 3161 (23 pages), doi: 10.3390/ijms25063161 (°IF 5.6) 

  • Legere EA, Baumholtz AI, Lachance JB, Archer M, Piontek J, Ryan AK  (2024) Claudin-3 in the non-neural ectoderm is essential for neural fold fusion in chicken embryos. Dev. Biol. 507: 20-33. doi: 10.1016/j.ydbio.2023.12.009 (°IF 2.7)


  • Waldow A*, Beier LS* (*shared first authorship), Arndt J, Schallenberg S, Vollbrecht C, Bischoff P, Farrera-Sal M, Loch FN, Bojarski C, Schumann M, Winkler L, Kamphues C, Ehlen L°, Piontek J° (°shared last authorship) (2023) cCPE fusion proteins as molecular probes to detect claudins and tight junction dysregulation in gastrointestinal cell lines, tissue explants and patient-derived organoids. Pharmaceutics 15(7): 1980 (23 pages). doi: 10.3390/pharmaceutics15071980 (°IF 5.4)

  • Nagarajan SK, Klein S, Fadakar BS, Piontek J (2023) Claudin-10b cation channels in tight junction strands: Octameric-interlocked pore barrels constitute paracellular channels with low water permeability Comp. Struct. Biotechnol. J. 21: 1711-1727, doi: 10.1016/j.csbj.2023.02.009 (°IF 6.0)


  • Beier LS*, Waldow A* (*shared first authorship), Khomeijani Farahani S, Mannweiler R, Vidal-Y-Sy S, Brandner JM, Piontek J°, Günzel D° (°shared last authorship) (2022) Claudin targeting as an effective tool for directed barrier modulation of the viable epidermis. Ann. NY Acad. Sci. 1517(1): 251-265, doi: 10.1111/nyas.14879 (IF 5.2)

  • Hempel C*, Rosenthal R* (*shared first authorship), Fromm A, Krug SM, Fromm M, Günzel D, Piontek J (2022) Tight junction channels claudin-10b and claudin-15: Functional mapping of pore-lining residues. Ann. NY Acad. Sci. 1515(1): 129-142, doi: 10.1111/nyas.14794 (IF 5.2)

  • Gonschior H, Schmied C, Van der Veen R, Eichhorst J, Himmerkus N, Piontek J, Günzel D, Bleich M, Furuse M, Haucke V, Lehmann M (2022) Nanoscale segregation of channel and barrier claudins enables paracellular ion flux. Nat. Commun. 13(1): 4985 (20 pages). doi: 10.1038/s41467-022-32533-4, Supplement (IF 16.6)

  • Sewerin S, Piontek J, Schönauer R, Grunewald S, Rauch A, Neuber S, Bergmann C, Günzel D*, Halbritter J* (*shared last authorship) (2022) Defective claudin-10 causes a novel variation of HELIX syndrome through compromised tight junction strand assembly. Genes & Dis. 9(5): 1301-1314. doi: 10.1016/j.gendis.2021.06.006 (IF 6.8)

  • Zejc T, Piontek J, Schulzke JD, Fromm M, Ervens J*, Rosenthal R* (*shared last authorship) (2022) Clinical significance of claudin expression in oral squamous cell carcinoma. Int. J. Mol. Sci. 23(19): 11234 (13 pages), doi: 10.3390/ijms231911234 (IF 5.6)

    • Book chapter

  • Beier LS, Piontek J, Piontek A, Protze J, Kobelt D, Walther W (2022) Claudin-targeted suicide gene therapy for claudin-overexpressing tumor cells by using modified Clostridium perfringens enterotoxin (CPE). In: Walter W (ed), Gene therapy of cancer. Methods Mol. Biol. 2521: 173-188. doi: 10.1007/978-1-0716-2441-8_9


  • Dias MC, Quesada AO, Soldati S, Boesch F, Gruber I, Hildbrand T, Soenmez D, Khire T, Witz G, McGrath JL, Piontek J, Kondoh M, Deutsch U, Zuber B, Engelhardt B (2021) Brain endothelial tricellular junctions as novel sites for T-cell diapedesis across the blood-brain barrier. J. Cell Sci. 134(8): jcs253880 (19 pages), doi: org/10.1242/jcs.253880,  Supplement PDF (IF 5.2)

  • Pahle J, Kobelt D, Aumann J, Behrens D, Daberkow O, Mokritzkij M, Piontek J, Stein U, Walther W (2021) Effective oncoleaking treatment of pancreatic cancer by claudin-targeted suicide gene therapy with Clostridium perfringens enterotoxin (CPE). Cancers 13(17): 4393 (26 pages). doi: 10.3390/cancers13174393, Supplement, (IF 6.6)



  • Beier LS, Rossa J, Woodhouse S, Bergmann S, Kramer HB, Protze J, Eichner M, Piontek A, Vidal-y-Sy S, Brandner JM, Krause G, Zitzmann N, Piontek J (2019) Use of modified Clostridium perfringens enterotoxin fragments for claudin targeting in liver and skin cells. Int. J. Mol. Sci. 20(19): 4774 (20 pages) (IF 4.6) [PubMed] [WebPage] [PDF] [Supplement PDF]



  • Piontek A, Rossa J, Protze J, Wolburg H, Hempel C, Günzel D, Krause G, Piontek J (2017) Polar and charged extracellular residues conserved among sealing claudins contribute to tight junction strand formation. Ann. N.Y. Acad. Sci. 1397: 143-156 (IF 4.3) [PubMed] [WebPage] [PDF]

  • Piontek A*, Witte C* (*shared first authorship), Rose H, Eichner M, Protze J, Krause G (corresponding author), Piontek J*, Schröder L* (*shared last authorship) (2017) A cCPE-based xenon biosensor for magnetic resonance imaging of claudin-expressing cells. Ann. N.Y. Acad. Sci. 1397: 195-208 (IF 4.3) [PubMed] [WebPage] [PDF]

  • Klar J, Piontek J, Milatz S, Tariq M, Jameel M, Breiderhoff T, Schuster J, Fatima A, Asif M, Sher M, Mäbert K, Fromm A, Baig SM, Günzel D, Dahl N (2017) Altered paracellular cation permeability due to a rare CLDN10B variant causes anhidrosis and kidney damage. Plos Genet. 13(7): e1006897 (22 pages + 6 Supplements) (IF 5.5) [PubMed] [WebPage] [PDF] [Supplement]

  • Baumholtz AI, Simard A, Nikolopoulou E, Oosenbrug M, Collins MM, Piontek A, Krause G, Piontek J, Greene NDE, Ryan AK (2017) Claudins are essential for cell shape changes and convergent extension movements during neural tube closure. Dev. Biol. 428(1): 25-38 (IF 3.3) [PubMed] [WebPage] [PDF]

  • Milatz S, Piontek J, Hempel C, Meoli L, Grohe C, Fromm A, Lee IM, El-Athman R, Günzel D (2017) Tight junction strand formation by claudin-10 isoforms and claudin-10a/-10b chimeras. Ann. N.Y. Acad. Sci. 1405: 102-115 (IF 4.3) [PubMed] [WebPage] [PDF]

  • Appelt-Menzel A, Cubukova A, Günther K, Edenhofer F, Piontek J, Krause G, Stüber T, Walles H, Neuhaus W, Metzger M (2017) Establishment of a human blood-brain barrier co-culture model mimicking the neurovascular unit using induced pluri- and multipotent stem cells. Stem Cell Rep. 8(4): 894-906 (IF 6.5) [PubMed] [WebPage] [PDF]

    • Reviews

  • Eichner M, Protze J, Piontek A, Krause G, Piontek J (2017) Targeting and alteration of tight junctions by bacteria and their virulence factors such as Clostridium perfringens enterotoxin. Pflügers Arch. 469(1): 77-90 (IF 2.8) [PubMed] [WebPage] [PDF]

  • Fromm M, Piontek J, Rosenthal R, Günzel D, Krug SM (2017) Tight junctions of the proximal tubule and their channel proteins. Pflügers Arch. 469(7-8): 877-887 (IF 2.8) [PubMed] [WebPage] [PDF]


  • Conrad MP*, Piontek J* (*shared first authorship), Günzel D, Fromm M, Krug SM (2016) Molecular basis of claudin-17 anion selectivity. Cell. Mol. Life Sci. 73(1): 185-200 (IF 5.9) [PubMed] [WebPage] [PDF] [Supplement]

  • Liao Z, Yang Z, Piontek A, Eichner M, Krause G, Chen B, Li L, Piontek J, Zhang J (2016) Specific binding of a mutated fragment of Clostridium perfringens enterotoxin to endothelial claudin-5 and its modulation of cerebral vascular permeability. Neuroscience 327: 53-63 (IF 3.3) [PubMed] [WebPage] [PDF]


  • Protze J, Eichner M, Piontek A, Dinter S, Rossa J, Blecharz KG, Vajkoczy P, Piontek J*, Krause G* (*shared last authorship) (2015) Directed structural modification of Clostridium perfringens enterotoxin to enhance binding to claudin-5. Cell. Mol. Life Sci. 72(7): 1417-1432 (IF 5.7) [PubMed] [WebPage] [PDF]

  • Zhang J*, Ni C*, Yang Z* (*shared first authorship), Piontek A, Chen H, Wang S, Fan Y, Qin Z, Piontek J (2015) Specific binding of Clostridium perfringens enterotoxin fragment 1 to claudin-b and modulation of zebrafish epidermal barrier. Exp. Dermatol. 24(8): 605-610 (IF 2.7) [PubMed] [WebPage] [PDF]

  • Milatz S, Piontek J, Schulzke JD, Blasig IE, Fromm M, Günzel D (2015) Probing the cis-arrangement of prototype tight junction proteins claudin-1 and claudin-3. Biochem. J. 468(3): 449-458 (IF 3.6) [PubMed] [WebPage] [PDF]

    • Review

  • Krause G, Protze J, Piontek J (2015) Assembly and function of claudins: Structure-function relationships based on homology models and crystal structures. Semin. Cell Devel. Biol. 42: 3-12 (IF 5.2) [PubMed] [WebPage] [PDF]



  • Rossa J, Plöger C, Vorreiter F, Saleh T, Protze J, Günzel D, Wolburg H, Krause G, Piontek J (2014) Claudin-3 and claudin-5 protein folding and assembly into the tight junction are controlled by non-conserved residues in transmembrane2 (TM3) and extracellular loop 2 (ECL2) segments. J. Biol. Chem. 289(11): 7641-7653 (IF 4.6) [PubMed] [WebPage] [PDF] [Supplements]

  • Rossa J*, Protze J* (*shared first authorship), Kern C, Piontek A, Günzel D, Krause G*, Piontek J* (*shared last authorship) (2014) Molecular and structural transmembrane determinants critical for embedding claudin-5 into tight junctions reveal distinct four helix bundle arrangement. Biochem. J. 464(1): 49-60 (IF 4.4) [PubMed] [WebPage] [PDF]



2010 - 2011


2006 - 2008

1999 - 2003