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Publications: Roland Bücker
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2024
Heimesaat MM, Mousavi S, Lobo de Sá FD, Peh E, Schulzke JD, Bücker R, Kittler S, Bereswill S (2024) Oral curcumin ameliorates acute murine campylobacteriosis. Front. Immunol. 15: 1363457 (14 pages). doi: 10.3389/fimmu.2024.1363457 (°IF 5.7)
2023
Awad K, Barmeyer C, Bojarski C, Nagel O, Lee IM, Schweiger MR, Schulzke JD*, Bücker R* (*shared last authorship) (2023) Epithelial barrier dysfunction in diarrhea-predominant irritable bowel syndrome (IBS-D) via downregulation of claudin-1. Cells 12(24), 2846 (17 pages). doi: 10.3390/cells12242846 (IF 5.1)
Awad K, Barmeyer C, Bojarski C, Nagel O, Lee IM, Schweiger MR, Schulzke JD*, Bücker R* (*shared last authorship) (2023) Impaired intestinal permeability of tricellular tight junctions in patients with irritable bowel syndrome with mixed bowel habits (IBS-M). Cells 12(2), 236 (19 pages); doi: 10.3390/cells12020236, Supplement (IF 5.1)
Heils L, Schneemann M, Gerhard R, Schulzke JD, Bücker R (2023) CDT of Clostridioides difficile induces MLC-dependent intestinal barrier dysfunction in HT-29/B6 epithelial cell monolayers. Toxins (Basel) 15(1): 54 (15 pages). doi: 10.3390/toxins15010054 (IF 3.9)
Omarova S, Awad K, Moos V, Püning C, Gölz G, Schulzke JD, Bücker R (2023) Intestinal barrier in post-Campylobacter jejuni irritable bowel syndrome. Biomolecules 13(3): 449 (14 pages). doi: 10.3390/biom13030449 (IF 4.8)
Schneemann M, Heils L, Moos V, Weiß F, Krug SM, Weiner J, Beule D, Gerhard R, Schulzke JD, Bücker R (2023) A colonic organoid model challenged with the large toxins of Clostridioides difficile TcdA and TcdB exhibit deregulated tight junction proteins. Toxins 15: 643 (19 pages). doi: 10.3390/toxins15110643 (IF 3.9)
Hader H, Hering NA, Schulzke JD, Bücker R, Rosenthal R (2023) Myrrh protects against IL-13-induced epithelial barrier breakdown in HT-29/B6 cells. Front. Pharmacol. 14: 1301800 (11 pages). doi: 10.3389/fphar.2023.1301800 (IF 4.4)
Mateus C, Maia CJ, Domingues F, Bücker R, Oleastro M, Ferreira S (2023) Evaluation of bile salts on the survival and modulation of virulence of Aliarcobacter butzleri. Antibiotics (Basel)
Edition
Bücker R, ed. (2023) Special Issue "Enterotoxins and mucosal pathomechanisms" in Toxins (Basel) (5 articles) (IF 3.9) Collection of papers
2022
Kaak JL, Lobo de Sá FD, Turner JR, Schulzke JD, Bücker R (2022) Unraveling the intestinal epithelial barrier in cyanotoxin microcystin-treated Caco-2 cell monolayers. Ann. NY Acad. Sci. 1516(1): 188-196, doi: 10.1111/nyas.14870 (IF 5.2)
Martins R, Mateus C, Domingues F, Bücker R, Oleastro M, Ferreira S (2022) Effect of atmospheric conditions on pathogenic phenotypes of Arcobacter butzleri. Microorganisms 10(12): 2409 (14 pages), doi: 10.3390/microorganisms10122409 (IF 4.5)
2021
Lobo de Sá FD, Backert S, Nattramilarasu PK, Mousavi S, Sandle GI, Bereswill S, Heimesaat MM, Schulzke JD, Bücker R (2021) Vitamin D reverses disruption of gut epithelial barrier function caused by Campylobacter jejuni.
Lobo de Sá FD, Heimesaat MM, Bereswill S, Nattramilarasu PK, Schulzke JD, Bücker R (2021) Resveratrol prevents Campylobacter jejuni-induced leaky gut by restoring occludin and claudin-5 in the paracellular leak pathway. Front. Pharmacol. 12: 640572. doi: 10.3389/fphar.2021.640572 (IF 6.0)
Lobo de Sá FD, Schulzke JD, Bücker R (2021) Diarrheal mechanisms and the role of intestinal barrier dysfunction in Campylobacter infections. Curr. Top. Microbiol. Immunol. 431: 203-231. doi: 10.1007/978-3-030-65481-8_8 (IF 4.7)
Nattramilarasu PK, Lobo de Sá FD, Schulzke JD, Bücker R (2021) Immune-mediated aggravation of the Campylobacter concisus-induced epithelial barrier dysfunction. Int. J. Mol. Sci. 22(4): 2043 (23 pages). doi: 10.3390/ijms22042043, Supplement PDF (IF 6.2)
Schulz E, Schumann M, Schneemann M, Dony V, Fromm A, Nagel O, Schulzke JD, Bücker R (2021) Escherichia coli alpha-hemolysin HlyA induces host cell polarity changes, epithelial barrier dysfunction and cell detachment in human colon carcinoma Caco-2 cell model via PTEN-dependent dysregulation of cell junctions. Toxins 13(8): 520 (22 pages). doi: 10.3390/toxins13080520. (IF 5.1)
2020
Bücker R, Zakrzewski SS, Wiegand S, Pieper R, Fromm A, Fromm M, Günzel D, Schulzke JD (2020) Zinc prevents intestinal epithelial barrier dysfunction induced by alpha-hemolysin-producing Escherichia coli 536 infection in porcine colon. Vet. Microbiol. 243: 108632 (6 pages) [PubMed] [WebPage] [PDF] [Supplement] (IF 3.3)
Butkevych E, Lobo De Sá FD, Nattramilarasu PK, Bücker R (2020) Contribution of epithelial apoptosis and subepithelial immune responses in Campylobacter jejuni-induced barrier disruption Front. Microbiol. 11: 344 (14 pages) (IF 5.6) [PubMed] [WebPage] [PDF]
Heimesaat MM, Mousavi S, Escher U, Lobo de Sá FD, Peh E, Schulzke JD, Kittler S, Bücker R, Bereswill S (2020) Resveratrol alleviates acute Campylobacter jejuni-induced enterocolitis in a preclinical murine intervention study. Microorganisms 8: 1858 (15 pages) (IF 4.1) [PubMed] [DOI] [PDF] [Supplement]
Nattramilarasu PK, Bücker R, Lobo de Sá FD, Fromm A, Nagel O, Lee IM, Butkevych E, Mousavi S, Genger C, Kløve S, Heimesaat MM, Bereswill S, Schweiger MR, Nielsen HL, Troeger H, Schulzke JD (2020) Campylobacter concisus impairs sodium absorption in colonic epithelium via ENaC dysfunction and claudin-8 disruption. Int. J. Mol. Sci. 21(2): e373 (23 pages) (IF 5.9) [PubMed] [WebPage] [PDF] [Supplements]
2019
Hering NA, Fromm A, Bücker R, Gorkiewicz G, Zechner EL, Högenauer C, Fromm M, Schulzke JD, Troeger H (2019) Tilivalline- and tilimycin-independent effects of Klebsiella oxytoca on tight junction-mediated intestinal barrier impairment. Int. J. Mol. Sci. 20(22): 5595 (16 pages) (IF 4.6) [PubMed] [WebPage] [PDF]
Lobo de Sá FD, Butkevych E, Nattramilarasu PK, Fromm A, Mousavi S, Moos V, Golz JC, Stingl K, Kittler S, Seinige D, Kehrenberg C, Heimesaat MM, Bereswill S, Schulzke JD*, Bücker R (*corresponding) (2019) Curcumin mitigates immune-induced epithelial barrier dysfunction by Campylobacter jejuni. Int. J. Mol. Sci. 20(19): 4830 (19 pages) [Pubmed] [WebPage] [PDF] (°IF 5.9)
Mousavi S, Lobo de Sá FD, Schulzke JD, Bücker R, Bereswill S, Heimesaat MM (2019) Vitamin D in acute campylobacteriosis ‒ results from an intervention study applying a clinical Campylobacter jejuni induced enterocolitis model. Front. Immunol. 10: 2094 (14 pages) (IF 5.1) [PubMed] [WebPage] [PDF]
Harrer A, Bücker R, Boehm M, Zarzecka U, Tegtmeyer N, Sticht H, Schulzke JD, Backert S (2019) Campylobacter jejuni enters gut epithelial cells and impairs intestinal barrier function through cleavage of occludin by serine protease HtrA. Gut Pathog. 11: 4 (IF 3.3) [PubMed] [WebPage] [PDF]
2018
Bücker R, Krug SM, Moos V, Bojarski C, Schweiger MR, Kerick M, Fromm A, Janßen S, Fromm M, Hering NA, Siegmund B, Schneider T, Barmeyer C, Schulzke JD (2018) Campylobacter jejuni impairs sodium transport and epithelial barrier function via cytokine release in human colon. Mucosal Immunol. 11(2): 474-485 (IF 7.4) [PubMed] [DOI] [PDF] [Supplement1] [Supplement2]
Bücker R, Schaefer C, Gruber AD, Hoppe J, Lazzerini L, Barinoff J, Sehouli J, Cichon G (2018) Establishment of a mucin secreting cell line Cx-03 from an uterine carcino sarcoma. Pharmaceut. Res. 36(1): 7 (IF 3.9) [PubMed] [WebSite] [PDF]
Eichner M, Augustin C, Fromm A, Piontek A, Walther W, Bücker R, Fromm M, Krause G, Schulzke JD, Günzel D, Piontek J (2018) In colon epithelia, Clostridium perfringens enterotoxin causes focal leaks by targeting claudins which are apically accessible due to tight junction derangement. J. Infect. Dis. 217(1): 147-157 (IF 5.0) [PubMed] [WebSite] [PDF]
2017
Bücker R, Krug SM, Fromm A, Nielsen HL, Fromm M, Nielsen H, Schulzke JD (2017) Campylobacter fetus
impairs barrier function in HT-29/B6 cells through focal tight junction alterations and leaks.
Wiegand S, Zakrzewski SS, Eichner M, Schulz E, Günzel D, Pieper R, Rosenthal R, Barmeyer C, Bleich A, Dobrindt U, Schulzke JD*, Bücker R* (*shared last authorship) (2017) Zinc treatment is efficient against Escherichia coli α haemolysin-induced intestinal leakage in mice. Sci. Rep. 7: 45649 (pages 1-13) (IF 4.1) [PubMed] [WebPage] [PDF]
Witkowski PT, Perley CC, Brocato RL, Hooper JW, Jürgensen C, Schulzke JD,
2016
Hering NA, Fromm A, Kikhney J, Lee IM, Moter A, Schulzke JD, Bücker R (2016) Yersinia enterocolitica affects intestinal barrier function in the colon. J. Infect. Dis. 213(7): 1157-1162 (IF 6.3) [PubMed] [WebPage] [PDF]
2015
Dames P, Bergann T, Fromm A, Bücker R, Barmeyer C, Krug SM, Fromm M, Schulzke JD (2015) Interleukin-13 affects the intestinal epithelial sodium channel (ENaC) by coordinated modulation of STAT6 and p38 MAPK activity. J. Physiol. (Lond.) 593(24): 5269-5282 (IF 4.7) [PubMed] [WebPage] [PDF]
Karadas G, Bücker R, Sharbati S, Schulzke JD, Gölz G (2015) Arcobacter butzleri isolates exhibit pathogenic potential in epithelial cell models. J. Appl. Microbiol. 120(1): 218-225 (IF 2.2) [PubMed] [WebPage] [Manuscript PDF]
2014
Bücker R, Schulz E, Günzel D, Bojarski C, Lee IM, John LJ, Wiegand S, Janßen T, Wieler LH, Dobrindt U, Beutin L, Ewers C, Fromm M, Siegmund B, Troeger H, Schulzke JD (2014) α-Haemolysin of Escherichia coli: a potentiator of inflammatory activity in the colon. Gut 63(12): 1893-1901 (IF 14.7) [PubMed] [WebPage] [PDF] [Supplements]
Yu C*, Achazi K* (*shared first authorship), Möller L, Schulzke JD, Niedrig M, Bücker R (2014) Tick-borne encephalitis virus replication, intracellular trafficking, and pathogenicity in human intestinal Caco-2 cell monolayers. PLOS One 9(5): e96957 (print pages 1-10) (IF 3.2) [PubMed] [WebPage] [PDF]
Hering NA*, Richter JF* (*shared first authorship), Fromm A, Wieser A, Hartmann S, Günzel D, Bücker R, Fromm M, Schulzke JD° (°corresponding author), Troeger H (2014) TcpC protein from E. coli Nissle improves epithelial barrier function involving PKCζ and ERK1/2 signalling in HT-29/B6 cells. Mucosal Immunol. 7(2): 369-378 (IF 7.4) [PubMed] [WebPage] [PDF]
Schneditz G, Rentner J, Roier S, Pletz J, Herzog KAT, Bücker R,
Troeger H, Schild S, Weber H, Breinbauer R, Gorkiewicz G, Högenauer C,
Zechner EL (2014) Enterotoxicity of a nonribosomal peptide causes
antibiotic-associated colitis. Proc.
Natl. Acad. Sci. USA 111(36): 13181-13186
(IF 9.7)
[PubMed] [WebPage]
[PDF]
2012
Bücker R, Azevedo-Vethacke M, Groll C, Garten D, Josenhans C, Suerbaum S, Schreiber S (2012) Helicobacter pylori colonization critically depends on postprandial gastric conditions. Sci. Rep. 2: 994 (print pages 1-10), doi:10.1038/srep00994 (IF 2.9) [PubMed] [WebPage] [PDF]
Bratz K, Bücker R, Gölz G, Zakrzewski SS, Janczyk P, Nöckler K, Alter T (2012) Experimental infection of weaned piglets with Campylobacter coli - excretion and translocation in a pig colonisation trial. Vet. Microbiol. 162(1): 136-142 (IF 3.1) [PubMed] [WebPage] [PDF]
Nielsen H, Engberg J, Ejlertsen T, Bücker R, Nielsen H (2012) Short-term and medium-term clinical outcomes of Campylobacter concisus infection. Clin. Microbiol. Infect. 18(11): E459-E465 (IF 4.6) [PubMed] [WebPage] [PDF]
2011
Bücker R, Krug SM, Rosenthal R, Günzel D, Fromm A, Zeitz M, Chakraborty T, Fromm M, Epple HJ, Schulzke JD (2011) Aerolysin from Aeromonas hydrophila perturbs tight junction integrity and cell lesion repair in intestinal epithelial HT-29/B6 cells. J. Infect. Dis. 204 (8): 1283-1292 (IF 6.
Hering NA, Richter JF, Krug SM, Günzel D, Fromm A, Bohn E, Rosenthal R, Bücker R, Fromm M, Troeger H, Schulzke JD (2011) Yersinia enterocolitica induces epithelial barrier dysfunction through regional tight junction changes in colonic HT-29/B6 cell monolayers. Lab. Invest. 91: 310-324 (IF 3.6) [PubMed] [WebPage] [PDF] [Supplement DOC]
Nielsen HL, Nielsen H, Ejlertsen T, Engberg J, Günzel D, Zeitz M, Hering NA, Fromm M, Schulzke JD, Bücker R (2011) Oral and fecal Campylobacter concisus strains perturb barrier function by apoptosis induction in HT-29/B6 intestinal epithelial cells. PLoS One 6(8): e23858 (print pages 1-8) (IF 4.1) [PubMed] [WebPage] [PDF]
2009, 2010
Bücker R*, Troeger H* (*shared first authorship), Kleer J, Fromm M, Schulzke JD (2009) Arcobacter butzleri induces barrier dysfunction in intestinal epithelial cells. J. Infect. Dis. 200(5): 756-764 (IF 5.9) [PubMed] [WebPage] [PDF]
Bücker R, Schumann M, Amasheh S, Schulzke JD (2010) Claudins in intestinal function and disease. Curr. Top. Membr. 65: 195-227 (IF 0.7) [Directory] [WebPage] [PDF] (review / book chapter)
2007
Schreiber S, Garten D, Nguyen TH, Konradt M, Bücker R, Scheid P (2007) In situ measurement of pH in the secreting canaliculus of the gastric parietal cell and adjacent structures. Cell Tiss. Res. 329(2): 313-320 (IF 2.6) [PubMed] [WebPage] [PDF]
Sudhoff H, Bücker R, Groll C, Shagdarsuren S, Dazert S, Schreiber S (2007) Tracing of gastric reflux into the middle ear in a mongolian gerbil model. Otol. Neurotol. 28(1): 124-128 (IF 1.4) [PubMed] [WebPage] [PDF]
2005, 2006
Schreiber S, Bücker R, Groll C, Azevedo-Vethacke M, Scheid P, Gatermann S, Josenhans C, Suerbaum S (2006) Gastric antibacterial efficiency is different for pepsin A and C. Arch. Microbiol. 184(5): 335-340 (IF 1.8) [PubMed] [WebPage] [PDF]
Schreiber S, Bücker R, Groll C, Baptista M, Garten D, Scheid P, Friedrich S, Josenhans C, Suerbaum S (2005) Rapid loss of motility of Helicobacter pylori in the gastric lumen in vivo. Infect. Immun. 73(3): 1584-1589 (IF 4.0) [PubMed]
Theses
Bücker R (2015) Pathomechanismen gestörter epithelialer Barrierefunktion durch bakterielle Enteropathogene. Habilitation thesis, Experimental biomedicine, Charité - Universitätsmedizin Berlin
Bücker R (2007) Die akute Kolonisation des Magenmucus durch Helicobacter pylori in vivo – der erste Schritt der Infektion. Doctoral thesis
Bücker R (2003) Der Einfluss verschiedener Pepsinisoenzyme auf das Überleben von Helicobacter pylori im Magenlumen in vivo. Diploma thesis [Supervision: PD. Dr. Sören Schreiber, Institut für Physiologie, Ruhr-Universität Bochum]
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