DFG Research Training Group "TJ-Train", GRK 2318

That's all about:

Very briefly: The tight junction (TJ) connects neighbouring epithelial or endothelial cells and is the central element of barrier function, as it controls paracellular passage of solutes and water. Whether the TJ simply increases tightness or selectively mediates permeability varies greatly in different tissues and is determined by the TJ protein composition. TJs underlie extensive extra- and intracellular signalling, but also regulate epithelial functions and cellular differentiation. Furthermore, numerous TJ proteins serve as receptors for certain pathogens. Thus, TJ proteins are involved in the pathogenesis of numerous diseases. Alterations in TJ composition and architecture may e.g. cause unwanted leak flux or antigen passage and may thus maintain disease activity or even directly trigger disease onset.

   

Projects and topics of theses 

     A:  Tight junction molecules, structure and function

Dorothee Günzel*
Clinical Physiology / Nutritional Medicine, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin
"Impedance analysis of epithelial barrier properties"
PhD doctoral student, 2^nd cohort: Saeed Khomeijani Farahani
PhD doctoral student, 1^st cohort: Roman Mannweiler
MD doctoral student, 1^st cohort: Ahmad Mouna

Jörg Piontek¹*, Gerd Krause^2
1Clinical Physiology / Nutritional Medicine, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin
²Structural Bioinformatics & Protein Design, Leibniz Research Institute of Molecular Pharmacology (FMP), Berlin-Buch
"Structure-based modification of Clostridium perfringens enterotoxin to target claudins"
PhD doctoral student, 2^nd cohort: Ayk Waldow
PhD doctoral student, 1^st cohort: Laura-Sophie Beier

Michael Fromm*, Jörg-Dieter Schulzke*
Clinical Physiology / Nutritional Medicine, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin
"Claudin- and TAMP-mediated water transport"
PhD doctoral student, 2^nd cohort: Fabián Martínez-Perafán
PhD doctoral student, 1^st cohort: Carlos Ayala-Torres

Martin Lehmann, Volker Haucke*
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin-Buch
"High- and super-resolution imaging of tight junction components"
PhD doctoral student, 2^nd cohort: Rozemarijn van der Veen
PhD doctoral student, 1^st cohort: Hannes Gonschior

     B:  Tight junction development and regulation

Thomas Willnow*, Annette Hammes (Annabel Christ)
Max-Delbrück-Centrum für Molekulare Medizin (MDC), Berlin-Buch
"Neuroepithelial barrier function in brain development"
PhD doctoral student, 2^nd cohort: Sher Min Mak
PhD doctoral student, 1^st cohort: Izabela Kowalczyk

Michael Hummel¹, Britta Siegmund^2
1Molecularpathology Section at the Institute of Pathology, Charité, CCM
²Medizinische Klinik m.S. Gastroenterologie, Infektiologie & Rheumatologie, Charité, CBF
"Tracking a primary barrier defect in celiac disease"
PhD doctoral student, 2^nd cohort: Subhakankha (Victor) Manna
PhD doctoral student, 1^st cohort: Danielle Cardoso-Silva

Dominik Müller*
Klinik für Pädiatrie m.S. Nephrologie, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum
"The magnesiome, an integrative view on magnesium regulation"
PhD doctoral student, 2^nd cohort: Amr Al-Shebel
PhD doctoral student, 1^st cohort: Murat Seker

Kai Schmidt-Ott*
Medizinische Klinik mit Schwerpunkt Nephrologie und Internistische Intensivmedizin, Charité - Universitätsmedizin Berlin and Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)
"Transcriptional integration of TJ assembly in renal epithelial cells"
PhD doctoral student, 2^nd cohort: Shuang Cao
PhD doctoral student, 1^st cohort: Janna Leiz
MD doctoral student, 1^st cohort: Alexander Holler

     C:  Tight junction modulation in disease

Jörg-Dieter Schulzke¹*, Hanno Troeger^2
1Clinical Physiology / Nutritional Medicine, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin
²Med. Klinik m.S. Gastroenterologie, Infektiologie & Rheumatologie, CBF, Charité - Universitätsmedizin Berlin
"Toxin effects on paracellular epithelial barrier function"
PhD doctoral student, 2^nd cohort: Martina Schneemann
PhD doctoral student, 1^st cohort: Praveen Kumar Nattramilarasu
MD doctoral student, 1^st cohort: Karem Awad
MD doctoral student, 1^st cohort: Lucas Heils
MD doctoral student, 1^st cohort: Sholpan Omarova
MD doctoral student, 1^st cohort: Eduard Butkevych

Susanne Krug*, Michael Fromm*
Clinical Physiology / Nutritional Medicine, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin
"Role of the tricellular tight junction in inflammatory bowel diseases (IBD)"
PhD doctoral student, 2^nd cohort: Lena Voges
PhD doctoral student, 1^st cohort: Jia-Chen E. Hu

Michael Schumann, Britta Siegmund*
Medizinische Klinik m.S. Gastroenterologie, Infektiologie & Rheumatologie, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin
"Epithelial dyspolarity in chronic intestinal imflammation"
PhD doctoral student, 2^nd cohort: Violaine Dony
PhD doctoral student, 1^st cohort: Deborah Delbue
MD doctoral student, 1^st cohort: Daphni Siampli

Hans-Jörg Epple*, Thomas Schneider
Medizinische Klinik m.S. Gastroenterologie, Infektiologie & Rheumatologie, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin
"Macromolecule uptake across the mucosa in HIV infection"
PhD doctoral student, 2^nd cohort: Valerie Masete
PhD doctoral student, 1^st cohort: Carolin Grünhagen
MD doctoral student, 1^st cohort: Hannah Lutz

  Steering committee (12.2020)

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